Contingent tolerance to amphetamine hypophagia: new insights into the role of environmental context in the expression of stereotypy

• Published in: Neuroscience and biobehavioral reviews Vol. 24; no. 3; pp. 279 - 294
• Main Author: Wolgin, D.L
• Format: Journal Article
• Language: English
• Published: United States 01.05.2000
• Subjects: Amphetamines - pharmacology; Animals; Appetite Depressants - pharmacology; Drug Tolerance; Eating - drug effects; Environment; Humans; Stereotyped Behavior - drug effects
• ISSN: 0149-7634
• DOI: 10.1016/S0149-7634(99)00070-6

A growing literature attests to the fact that the environment in which a drug is given can have a profound effect on the development and expression of tolerance and sensitization. The dominant paradigm for studying such context-dependency is based on Pavlovian conditioning, in which a distinctive en...