Morphologic spectrum of immunohistochemically characterized clear cell carcinoma of the ovary: a study of 155 cases

• Published in: The American journal of surgical pathology Vol. 35; no. 1; p. 36
• Main Authors: DeLair, Deborah, Oliva, Esther, Köbel, Martin, Macias, Antonio, Gilks, C Blake, Soslow, Robert A
• Format: Journal Article
• Language: English
• Published: United States 01.01.2011
• Subjects: Biomarkers, Tumor - analysis; Canada; Carcinoma - chemistry; Carcinoma - pathology; Cell Nucleus - pathology; Cytoplasm - pathology; Female; Hepatocyte Nuclear Factor 1-beta - analysis; Humans; Immunohistochemistry; Immunophenotyping; Mitosis; Neoplasm Staging; Ovarian Neoplasms - chemistry; Ovarian Neoplasms - pathology; Predictive Value of Tests; Receptors, Estrogen - analysis; Receptors, Progesterone - analysis; Tumor Suppressor Protein p53 - analysis; United States; WT1 Proteins - analysis; Canada; United States

Establishing a diagnosis of ovarian clear cell carcinoma (O-CCC) can be subject to significant interobserver variation. Accurately diagnosing this tumor is important because of its chemoresistance and reported association with Lynch syndrome. The spectrum of the morphologic features of O-CCC has not...