Anticancer activity of dinuclear gallium(III) carboxylate complexes

The reaction of 3-methoxyphenylacetic acid, 4-methoxyphenylacetic acid, mesitylthioacetic acid, 2,5-dimethyl-3-furoic acid and 1,4-benzodioxane-6-carboxylic acid with trimethylgallium (1:1) yielded the dimeric complexes [Me(2)Ga(micro-O(2)CCH(2)C(6)H(4)-3-OMe)](2) (1), [Me(2)Ga(micro-O(2)CCH(2)C(6)H...

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Published in	European journal of medicinal chemistry Vol. 45; no. 2; pp. 519 - 525
Main Authors	KALUDEROVIC, Milena R, GOMEZ-RUIZ, Santiago, GALLEGO, Beatriz, HEY-HAWKINS, Evamarie, PASCHKE, Reinhard, KALUDEROVIC, Goran N
Format	Journal Article
Language	English
Published	Kidlington Elsevier 01.02.2010
Subjects	Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Biological and medical sciences Carboxylic Acids - chemistry Cell Line, Tumor Cell Survival - drug effects Gallium - chemistry General aspects Humans Inhibitory Concentration 50 Medical sciences Models, Molecular Molecular Conformation Organometallic Compounds - chemical synthesis Organometallic Compounds - chemistry Organometallic Compounds - pharmacology Pharmacology. Drug treatments Spectrum Analysis Antineoplastic agent Human Gallium Carboxylato ligands Gallium Organic compounds Organic ligand Anticancer drugs Cytotoxicity Gallium III Complexes Transition metal Complexes Trivalent metal Complexes In vitro Cisplatin Mu complex Cell line Structure activity relation Carboxylate Dinuclear complex Chemical synthesis Tumor cell
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Abstract	The reaction of 3-methoxyphenylacetic acid, 4-methoxyphenylacetic acid, mesitylthioacetic acid, 2,5-dimethyl-3-furoic acid and 1,4-benzodioxane-6-carboxylic acid with trimethylgallium (1:1) yielded the dimeric complexes [Me(2)Ga(micro-O(2)CCH(2)C(6)H(4)-3-OMe)](2) (1), [Me(2)Ga(micro-O(2)CCH(2)C(6)H(4)-4-OMe)](2) (2), [Me(2)Ga(micro-O(2)CCH(2)SMes)](2) (3) (Mes=2,4,6-Me(3)C(6)H(2)), [Me(2)Ga{micro-O(2)C(Fur)}](2) (4) (Fur=2,5-dimethylfuran) and [Me(2)Ga{micro-O(2)C(Bdo)}](2) (5) (Bdo=1,4-benzodioxane) respectively. The molecular structure of 5 was determined by X-ray diffraction studies. The cytotoxic activity of the gallium(III) complexes (1-5) was tested against human tumor cell lines 8505C anaplastic thyroid cancer, A253 head and neck tumor, A549 lung carcinoma, A2780 ovarian cancer, DLD-1 colon carcinoma and compared with that of cisplatin. Taking into account the standard deviation, there is no significant difference in the activity for any of the compounds in any cell line. However, complex 5 presents the best IC(50) value against A253 head and neck tumor (6.6+/-0.2 microM), while complex 3 seems to be the most active against A2780 ovarian cancer (12.0+/-0.4 microM) and marginally on DLD-1 colon carcinoma (12.4+/-0.1 microM).
AbstractList	The reaction of 3-methoxyphenylacetic acid, 4-methoxyphenylacetic acid, mesitylthioacetic acid, 2,5-dimethyl-3-furoic acid and 1,4-benzodioxane-6-carboxylic acid with trimethylgallium (1:1) yielded the dimeric complexes [Me(2)Ga(micro-O(2)CCH(2)C(6)H(4)-3-OMe)](2) (1), [Me(2)Ga(micro-O(2)CCH(2)C(6)H(4)-4-OMe)](2) (2), [Me(2)Ga(micro-O(2)CCH(2)SMes)](2) (3) (Mes=2,4,6-Me(3)C(6)H(2)), [Me(2)Ga{micro-O(2)C(Fur)}](2) (4) (Fur=2,5-dimethylfuran) and [Me(2)Ga{micro-O(2)C(Bdo)}](2) (5) (Bdo=1,4-benzodioxane) respectively. The molecular structure of 5 was determined by X-ray diffraction studies. The cytotoxic activity of the gallium(III) complexes (1-5) was tested against human tumor cell lines 8505C anaplastic thyroid cancer, A253 head and neck tumor, A549 lung carcinoma, A2780 ovarian cancer, DLD-1 colon carcinoma and compared with that of cisplatin. Taking into account the standard deviation, there is no significant difference in the activity for any of the compounds in any cell line. However, complex 5 presents the best IC(50) value against A253 head and neck tumor (6.6+/-0.2 microM), while complex 3 seems to be the most active against A2780 ovarian cancer (12.0+/-0.4 microM) and marginally on DLD-1 colon carcinoma (12.4+/-0.1 microM).
Author	KALUDEROVIC, Milena R KALUDEROVIC, Goran N GALLEGO, Beatriz HEY-HAWKINS, Evamarie GOMEZ-RUIZ, Santiago PASCHKE, Reinhard
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Cites_doi	10.1016/j.jorganchem.2007.06.065 10.1158/1535-7163.MCT-06-0557 10.1021/om960576q 10.1016/S0010-8545(98)00268-9 10.1097/01.cco.0000142071.22226.d2 10.1016/j.jorganchem.2009.02.027 10.1155/MBD.2000.33 10.1039/B712656P 10.1016/j.jinorgbio.2006.07.003 10.1016/j.jinorgbio.2008.07.009 10.1002/ardp.200600151 10.1016/j.jinorgbio.2007.04.013 10.1016/0006-2952(92)90686-D 10.1016/j.jinorgbio.2008.02.001 10.1016/0883-2897(89)90053-6 10.1021/jm040763n 10.1097/00006231-200401000-00007 10.1021/jm0612618 10.1016/j.ejmech.2008.11.006 10.1016/S1040-8428(01)00225-6 10.1097/00001813-199906000-00008 10.1158/0008-5472.CAN-07-1813 10.1002/chem.200900151 10.1016/j.ccr.2007.12.026 10.1124/jpet.105.099044 10.1595/003214001X4526269 10.2174/092986706776872970 10.1016/S0010-8545(00)80455-5 10.1016/S0020-1693(97)06017-9 10.1016/S0277-5387(98)00096-5 10.1039/b707440a 10.1016/j.jorganchem.2009.01.054 10.1039/B707077M 10.2174/1568026043387449 10.1021/ja01189a003 10.1039/b008858g 10.1016/S0162-0134(02)00419-1 10.1039/b707310k 10.1172/JCI112746 10.1158/1535-7163.MCT-06-0285 10.5414/CPP43590 10.1021/ja00839a011 10.1016/S0093-7754(03)00172-6 10.1039/a905281j 10.1093/jnci/82.13.1107 10.1016/S0022-328X(00)89098-1
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Keywords	Antineoplastic agent Human Gallium Carboxylato ligands Gallium Organic compounds Organic ligand Anticancer drugs Cytotoxicity Gallium III Complexes Transition metal Complexes Trivalent metal Complexes In vitro Cisplatin Mu complex Cell line Structure activity relation Carboxylate Dinuclear complex Chemical synthesis Tumor cell
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References	Gust (10.1016/j.ejmech.2009.10.038_bib10) 2004; 47 Kinuya (10.1016/j.ejmech.2009.10.038_bib20) 2004; 25 Jakupec (10.1016/j.ejmech.2009.10.038_bib16) 2004; vol. 42 Davies (10.1016/j.ejmech.2009.10.038_bib21) 2006; 317 Soper (10.1016/j.ejmech.2009.10.038_bib57) 1948; 70 Keys (10.1016/j.ejmech.2009.10.038_bib43) 2000 Gómez-Ruiz (10.1016/j.ejmech.2009.10.038_bib47) 2008; 102 Ott (10.1016/j.ejmech.2009.10.038_bib4) 2007; 340 Narasimhan (10.1016/j.ejmech.2009.10.038_bib22) 1992; 44 Pal (10.1016/j.ejmech.2009.10.038_bib45) 2007; 692 Chua (10.1016/j.ejmech.2009.10.038_bib33) 2006; 26 Chitambar (10.1016/j.ejmech.2009.10.038_bib27) 2004; 16 Abu-Surrah (10.1016/j.ejmech.2009.10.038_bib2) 2006; 13 Perchellet (10.1016/j.ejmech.2009.10.038_bib25) 1999; 10 Deacon (10.1016/j.ejmech.2009.10.038_bib53) 1980; 33 Green (10.1016/j.ejmech.2009.10.038_bib13) 1989; 16 Jakupec (10.1016/j.ejmech.2009.10.038_bib17) 2004; 4 Sheldrick (10.1016/j.ejmech.2009.10.038_bib59) 1997 Bernstein (10.1016/j.ejmech.2009.10.038_bib12) 1998; 50 Kowol (10.1016/j.ejmech.2009.10.038_bib37) 2007; 50 Branch (10.1016/j.ejmech.2009.10.038_bib44) 2001 Chitambar (10.1016/j.ejmech.2009.10.038_bib19) 1986; 78 Harpstrite (10.1016/j.ejmech.2009.10.038_bib38) 2007; 101 Rudnev (10.1016/j.ejmech.2009.10.038_bib39) 2006; 100 Arion (10.1016/j.ejmech.2009.10.038_bib14) 2002; 91 Niesvitzky (10.1016/j.ejmech.2009.10.038_bib26) 2003; 30 Thiel (10.1016/j.ejmech.2009.10.038_bib30) 1999; vol. 54 Bernstein (10.1016/j.ejmech.2009.10.038_bib31) 2000; 7 Collery (10.1016/j.ejmech.2009.10.038_bib32) 2000; 20 Abeysinghe (10.1016/j.ejmech.2009.10.038_bib9) 2007 Jakupec (10.1016/j.ejmech.2009.10.038_bib5) 2008 Gómez-Ruiz (10.1016/j.ejmech.2009.10.038_bib48) 2008; 102 Lippert (10.1016/j.ejmech.2009.10.038_bib1) 1999 Chitambar (10.1016/j.ejmech.2009.10.038_bib18) 1987; 47 Mendes (10.1016/j.ejmech.2009.10.038_bib40) 2009; 44 Pérez-Quintanilla (10.1016/j.ejmech.2009.10.038_bib50) 2009; 15 Allardyce (10.1016/j.ejmech.2009.10.038_bib3) 2001; 45 Stephens (10.1016/j.ejmech.2009.10.038_bib41) 1998; 273 Cremer (10.1016/j.ejmech.2009.10.038_bib55) 1975; 97 Keys (10.1016/j.ejmech.2009.10.038_bib42) 1998; 17 Strohfeldt (10.1016/j.ejmech.2009.10.038_bib8) 2008; 37 Sheldrick (10.1016/j.ejmech.2009.10.038_bib60) 1997 Bethley (10.1016/j.ejmech.2009.10.038_bib54) 1997; 16 Chen (10.1016/j.ejmech.2009.10.038_bib29) 2007; 67 Skehan (10.1016/j.ejmech.2009.10.038_bib56) 1990; 82 Yang (10.1016/j.ejmech.2009.10.038_bib6) 1999; 185 Bellamy (10.1016/j.ejmech.2009.10.038_bib52) 1975 Lum (10.1016/j.ejmech.2009.10.038_bib34) 2003; 22 Hartinger (10.1016/j.ejmech.2009.10.038_bib11) 2009; 38 (10.1016/j.ejmech.2009.10.038_bib58) 2006 Bernstein (10.1016/j.ejmech.2009.10.038_bib15) 2005 Hofheinz (10.1016/j.ejmech.2009.10.038_bib35) 2005; 43 Collery (10.1016/j.ejmech.2009.10.038_bib28) 2002; 42 Yang (10.1016/j.ejmech.2009.10.038_bib24) 2007; 6 Allamneni (10.1016/j.ejmech.2009.10.038_bib36) 2004; 45 Hadjikakou (10.1016/j.ejmech.2009.10.038_bib7) 2009; 253 Hausen (10.1016/j.ejmech.2009.10.038_bib46) 1978; 160 Chitambar (10.1016/j.ejmech.2009.10.038_bib23) 2006; 5 Gómez-Ruiz (10.1016/j.ejmech.2009.10.038_bib49) 2009; 694 Gómez-Ruiz (10.1016/j.ejmech.2009.10.038_bib51) 2009; 694
References_xml	– volume: vol. 54 start-page: 439 year: 1999 ident: 10.1016/j.ejmech.2009.10.038_bib30 contributor: fullname: Thiel – volume: 692 start-page: 4237 year: 2007 ident: 10.1016/j.ejmech.2009.10.038_bib45 publication-title: J. Organomet. Chem. doi: 10.1016/j.jorganchem.2007.06.065 contributor: fullname: Pal – volume: 6 start-page: 633 year: 2007 ident: 10.1016/j.ejmech.2009.10.038_bib24 publication-title: Mol. Cancer Ther. doi: 10.1158/1535-7163.MCT-06-0557 contributor: fullname: Yang – volume: 16 start-page: 329 year: 1997 ident: 10.1016/j.ejmech.2009.10.038_bib54 publication-title: Organometallics doi: 10.1021/om960576q contributor: fullname: Bethley – volume: 185 start-page: 189 year: 1999 ident: 10.1016/j.ejmech.2009.10.038_bib6 publication-title: Coord. Chem. Rev. doi: 10.1016/S0010-8545(98)00268-9 contributor: fullname: Yang – volume: 16 start-page: 547 year: 2004 ident: 10.1016/j.ejmech.2009.10.038_bib27 publication-title: Curr. Opin. Oncol. doi: 10.1097/01.cco.0000142071.22226.d2 contributor: fullname: Chitambar – volume: 20 start-page: 955 year: 2000 ident: 10.1016/j.ejmech.2009.10.038_bib32 publication-title: Anticancer Res. contributor: fullname: Collery – volume: vol. 42 start-page: 425 year: 2004 ident: 10.1016/j.ejmech.2009.10.038_bib16 contributor: fullname: Jakupec – volume: 694 start-page: 2191 year: 2009 ident: 10.1016/j.ejmech.2009.10.038_bib51 publication-title: J. Organomet. Chem. doi: 10.1016/j.jorganchem.2009.02.027 contributor: fullname: Gómez-Ruiz – volume: 7 start-page: 33 year: 2000 ident: 10.1016/j.ejmech.2009.10.038_bib31 publication-title: Met. Based Drugs doi: 10.1155/MBD.2000.33 contributor: fullname: Bernstein – start-page: 183 year: 2008 ident: 10.1016/j.ejmech.2009.10.038_bib5 publication-title: Dalton Trans. doi: 10.1039/B712656P contributor: fullname: Jakupec – volume: 50 start-page: 665 year: 1998 ident: 10.1016/j.ejmech.2009.10.038_bib12 publication-title: Pharmacol. Rev. contributor: fullname: Bernstein – volume: 100 start-page: 1819 year: 2006 ident: 10.1016/j.ejmech.2009.10.038_bib39 publication-title: J. Inorg. Biochem. doi: 10.1016/j.jinorgbio.2006.07.003 contributor: fullname: Rudnev – volume: 102 start-page: 2087 year: 2008 ident: 10.1016/j.ejmech.2009.10.038_bib48 publication-title: J. Inorg. Biochem. doi: 10.1016/j.jinorgbio.2008.07.009 contributor: fullname: Gómez-Ruiz – volume: 340 start-page: 117 year: 2007 ident: 10.1016/j.ejmech.2009.10.038_bib4 publication-title: Arch. Pharm. doi: 10.1002/ardp.200600151 contributor: fullname: Ott – volume: 101 start-page: 1347 year: 2007 ident: 10.1016/j.ejmech.2009.10.038_bib38 publication-title: J. Inorg. Biochem. doi: 10.1016/j.jinorgbio.2007.04.013 contributor: fullname: Harpstrite – volume: 44 start-page: 2403 year: 1992 ident: 10.1016/j.ejmech.2009.10.038_bib22 publication-title: Biochem. Pharmacol. doi: 10.1016/0006-2952(92)90686-D contributor: fullname: Narasimhan – volume: 102 start-page: 1558 year: 2008 ident: 10.1016/j.ejmech.2009.10.038_bib47 publication-title: J. Inorg. Biochem. doi: 10.1016/j.jinorgbio.2008.02.001 contributor: fullname: Gómez-Ruiz – volume: 16 start-page: 435 year: 1989 ident: 10.1016/j.ejmech.2009.10.038_bib13 publication-title: Int. J. Radiat. Appl. Instrum. B doi: 10.1016/0883-2897(89)90053-6 contributor: fullname: Green – volume: 47 start-page: 5837 year: 2004 ident: 10.1016/j.ejmech.2009.10.038_bib10 publication-title: J. Med. Chem. doi: 10.1021/jm040763n contributor: fullname: Gust – volume: 25 start-page: 49 year: 2004 ident: 10.1016/j.ejmech.2009.10.038_bib20 publication-title: Nucl. Med. Commun. doi: 10.1097/00006231-200401000-00007 contributor: fullname: Kinuya – volume: 47 start-page: 3929 year: 1987 ident: 10.1016/j.ejmech.2009.10.038_bib18 publication-title: Cancer Res. contributor: fullname: Chitambar – year: 1997 ident: 10.1016/j.ejmech.2009.10.038_bib60 contributor: fullname: Sheldrick – volume: 50 start-page: 1254 year: 2007 ident: 10.1016/j.ejmech.2009.10.038_bib37 publication-title: J. Med. Chem. doi: 10.1021/jm0612618 contributor: fullname: Kowol – year: 1975 ident: 10.1016/j.ejmech.2009.10.038_bib52 contributor: fullname: Bellamy – volume: 45 start-page: 230 year: 2004 ident: 10.1016/j.ejmech.2009.10.038_bib36 publication-title: Proc. Am. Assoc. Cancer Res. contributor: fullname: Allamneni – volume: 44 start-page: 1870 year: 2009 ident: 10.1016/j.ejmech.2009.10.038_bib40 publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2008.11.006 contributor: fullname: Mendes – volume: 42 start-page: 283 year: 2002 ident: 10.1016/j.ejmech.2009.10.038_bib28 publication-title: Crit. Rev. Oncol. Hematol. doi: 10.1016/S1040-8428(01)00225-6 contributor: fullname: Collery – volume: 22 start-page: 943 year: 2003 ident: 10.1016/j.ejmech.2009.10.038_bib34 publication-title: Proc. Am. Soc. Clin. Oncol. contributor: fullname: Lum – volume: 10 start-page: 477 year: 1999 ident: 10.1016/j.ejmech.2009.10.038_bib25 publication-title: Anti-Cancer Drugs doi: 10.1097/00001813-199906000-00008 contributor: fullname: Perchellet – volume: 67 start-page: 9258 year: 2007 ident: 10.1016/j.ejmech.2009.10.038_bib29 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-07-1813 contributor: fullname: Chen – volume: 15 start-page: 5588 year: 2009 ident: 10.1016/j.ejmech.2009.10.038_bib50 publication-title: Chem. —Eur. J. doi: 10.1002/chem.200900151 contributor: fullname: Pérez-Quintanilla – volume: 253 start-page: 235 year: 2009 ident: 10.1016/j.ejmech.2009.10.038_bib7 publication-title: Coord. Chem. Rev. doi: 10.1016/j.ccr.2007.12.026 contributor: fullname: Hadjikakou – volume: 317 start-page: 153 year: 2006 ident: 10.1016/j.ejmech.2009.10.038_bib21 publication-title: J. Pharmacol. Exp. Ther. doi: 10.1124/jpet.105.099044 contributor: fullname: Davies – volume: 45 start-page: 62 year: 2001 ident: 10.1016/j.ejmech.2009.10.038_bib3 publication-title: Platinum Met. Rev. doi: 10.1595/003214001X4526269 contributor: fullname: Allardyce – volume: 13 start-page: 1337 year: 2006 ident: 10.1016/j.ejmech.2009.10.038_bib2 publication-title: Curr. Med. Chem. doi: 10.2174/092986706776872970 contributor: fullname: Abu-Surrah – volume: 33 start-page: 227 year: 1980 ident: 10.1016/j.ejmech.2009.10.038_bib53 publication-title: Coord. Chem. Rev. doi: 10.1016/S0010-8545(00)80455-5 contributor: fullname: Deacon – start-page: 259 year: 2005 ident: 10.1016/j.ejmech.2009.10.038_bib15 contributor: fullname: Bernstein – volume: 273 start-page: 47 year: 1998 ident: 10.1016/j.ejmech.2009.10.038_bib41 publication-title: Inorg. Chim. Acta doi: 10.1016/S0020-1693(97)06017-9 contributor: fullname: Stephens – volume: 17 start-page: 3121 year: 1998 ident: 10.1016/j.ejmech.2009.10.038_bib42 publication-title: Polyhedron doi: 10.1016/S0277-5387(98)00096-5 contributor: fullname: Keys – start-page: 3474 year: 2007 ident: 10.1016/j.ejmech.2009.10.038_bib9 publication-title: Dalton Trans. doi: 10.1039/b707440a contributor: fullname: Abeysinghe – volume: 694 start-page: 1981 year: 2009 ident: 10.1016/j.ejmech.2009.10.038_bib49 publication-title: J. Organomet. Chem. doi: 10.1016/j.jorganchem.2009.01.054 contributor: fullname: Gómez-Ruiz – volume: 38 start-page: 391 year: 2009 ident: 10.1016/j.ejmech.2009.10.038_bib11 publication-title: Chem. Soc. Rev. doi: 10.1039/B707077M contributor: fullname: Hartinger – volume: 4 start-page: 1575 year: 2004 ident: 10.1016/j.ejmech.2009.10.038_bib17 publication-title: Curr. Top. Med. Chem. doi: 10.2174/1568026043387449 contributor: fullname: Jakupec – volume: 70 start-page: 2849 year: 1948 ident: 10.1016/j.ejmech.2009.10.038_bib57 publication-title: J. Am. Chem. Soc. doi: 10.1021/ja01189a003 contributor: fullname: Soper – year: 1997 ident: 10.1016/j.ejmech.2009.10.038_bib59 contributor: fullname: Sheldrick – start-page: 1253 year: 2001 ident: 10.1016/j.ejmech.2009.10.038_bib44 publication-title: J. Chem. Soc., Dalton Trans. doi: 10.1039/b008858g contributor: fullname: Branch – volume: 91 start-page: 298 year: 2002 ident: 10.1016/j.ejmech.2009.10.038_bib14 publication-title: J. Inorg. Biochem. doi: 10.1016/S0162-0134(02)00419-1 contributor: fullname: Arion – volume: 37 start-page: 1174 year: 2008 ident: 10.1016/j.ejmech.2009.10.038_bib8 publication-title: Chem. Soc. Rev. doi: 10.1039/b707310k contributor: fullname: Strohfeldt – volume: 78 start-page: 1538 year: 1986 ident: 10.1016/j.ejmech.2009.10.038_bib19 publication-title: J. Clin. Invest. doi: 10.1172/JCI112746 contributor: fullname: Chitambar – volume: 5 start-page: 2834 year: 2006 ident: 10.1016/j.ejmech.2009.10.038_bib23 publication-title: Mol. Cancer Ther. doi: 10.1158/1535-7163.MCT-06-0285 contributor: fullname: Chitambar – volume: 26 start-page: 1739 year: 2006 ident: 10.1016/j.ejmech.2009.10.038_bib33 publication-title: Anticancer Res. contributor: fullname: Chua – volume: 43 start-page: 590 year: 2005 ident: 10.1016/j.ejmech.2009.10.038_bib35 publication-title: Int. J. Clin. Pharmacol. Ther. doi: 10.5414/CPP43590 contributor: fullname: Hofheinz – volume: 97 start-page: 1354 year: 1975 ident: 10.1016/j.ejmech.2009.10.038_bib55 publication-title: J. Am. Chem. Soc. doi: 10.1021/ja00839a011 contributor: fullname: Cremer – year: 2006 ident: 10.1016/j.ejmech.2009.10.038_bib58 – volume: 30 start-page: 20 year: 2003 ident: 10.1016/j.ejmech.2009.10.038_bib26 publication-title: Semin. Oncol. doi: 10.1016/S0093-7754(03)00172-6 contributor: fullname: Niesvitzky – year: 1999 ident: 10.1016/j.ejmech.2009.10.038_bib1 contributor: fullname: Lippert – start-page: 577 year: 2000 ident: 10.1016/j.ejmech.2009.10.038_bib43 publication-title: J. Chem. Soc., Dalton Trans. doi: 10.1039/a905281j contributor: fullname: Keys – volume: 82 start-page: 1107 year: 1990 ident: 10.1016/j.ejmech.2009.10.038_bib56 publication-title: J. Natl. Cancer Inst. doi: 10.1093/jnci/82.13.1107 contributor: fullname: Skehan – volume: 160 start-page: 411 year: 1978 ident: 10.1016/j.ejmech.2009.10.038_bib46 publication-title: J. Organomet. Chem. doi: 10.1016/S0022-328X(00)89098-1 contributor: fullname: Hausen
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SubjectTerms	Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Biological and medical sciences Carboxylic Acids - chemistry Cell Line, Tumor Cell Survival - drug effects Gallium - chemistry General aspects Humans Inhibitory Concentration 50 Medical sciences Models, Molecular Molecular Conformation Organometallic Compounds - chemical synthesis Organometallic Compounds - chemistry Organometallic Compounds - pharmacology Pharmacology. Drug treatments Spectrum Analysis
Title	Anticancer activity of dinuclear gallium(III) carboxylate complexes
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