Interdisciplinary Analysis of HIV-Specific CD8+ T Cell Responses against Variant Epitopes Reveals Restricted TCR Promiscuity

• Published in: The Journal of immunology (1950) Vol. 184; no. 9; pp. 5383 - 5391
• Main Authors: Hoof, Ilka, Pérez, Carina L, Buggert, Marcus, Gustafsson, Rasmus K L, Nielsen, Morten, Lund, Ole, Karlsson, Annika C
• Format: Journal Article
• Language: English
• Published: United States 01.05.2010
• Subjects: Amino Acid Substitution - genetics; Amino Acid Substitution - immunology; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - metabolism; CD8-Positive T-Lymphocytes - virology; Cytotoxicity, Immunologic - genetics; Epitopes, T-Lymphocyte - genetics; Epitopes, T-Lymphocyte - immunology; Epitopes, T-Lymphocyte - metabolism; Female; Histocompatibility Antigens Class I - genetics; Histocompatibility Antigens Class I - immunology; Histocompatibility Antigens Class I - metabolism; HIV-1 - immunology; HLA-A Antigens - genetics; HLA-A Antigens - immunology; HLA-A Antigens - metabolism; HLA-A2 Antigen - genetics; HLA-A2 Antigen - immunology; HLA-A2 Antigen - metabolism; HLA-B Antigens - genetics; HLA-B Antigens - immunology; HLA-B Antigens - metabolism; HLA-B44 Antigen; HLA-B7 Antigen; Humans; Male; Molecular Sequence Data; Predictive Value of Tests; Receptors, Antigen, T-Cell - genetics; Receptors, Antigen, T-Cell - immunology; Receptors, Antigen, T-Cell - metabolism

HIV-1–specific CTL responses play a key role in limiting viral replication. CTL responses are sensitive to viral escape mutations, which influence recognition of the virus. Although CTLs have been shown to recognize epitope variants, the extent of this cross-reactivity has not been quantitatively in...