Aerobic exercise training alleviates renal injury in db/db mice through inhibiting Nox4-mediated NLRP3 inflammasome activation

• Published in: Experimental gerontology Vol. 168; p. 111934
• Main Authors: Zhou, Zhongyuan, Ying, Changjiang, Zhou, Xiaoyan, Shi, Yuanyuan, Xu, Jian, Zhu, Yandong, Wang, Meng, Li, Yan, Li, Xiaofei, Xiang, Jie
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 15.10.2022
• Subjects: Aerobic exercise training; Diabetic kidney disease; Fibrosis; NLRP3 inflammasome; Nox4; Oxidative stress; Nox4; Oxidative stress; Aerobic exercise training; NLRP3 inflammasome; Fibrosis; Diabetic kidney disease

Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease, with few therapeutic options available to slow its progression. Aerobic exercise training is an effective strategy for diabetes mellitus and its complications' prevention and treatment. The purpose of this study was...