Increase of GABAA receptor-mediated tonic inhibition in dentate granule cells after traumatic brain injury

• Published in: Neurobiology of disease Vol. 38; no. 3; pp. 464 - 475
• Main Authors: Mtchedlishvili, Zakaria, Lepsveridze, Eka, Xu, Hong, Kharlamov, Elena A, Lu, Bo, Kelly, Kevin M
• Format: Journal Article
• Language: English
• Published: United States Elsevier 01.06.2010
• Subjects: Animals; Brain Injuries - physiopathology; Dentate granule cells; Dentate Gyrus - drug effects; Dentate Gyrus - physiopathology; Diazepam; Diazepam - pharmacology; Furosemide; Furosemide - pharmacology; GABA Agonists - pharmacology; GABA Modulators - pharmacology; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; GABAA receptor; Hippocampus - drug effects; Hippocampus - physiopathology; In Vitro Techniques; Inhibitory Postsynaptic Potentials - drug effects; Inhibitory Postsynaptic Potentials - physiology; Isoxazoles - pharmacology; Male; Neural Inhibition - drug effects; Neural Inhibition - physiology; Neurology; Neurons - drug effects; Neurons - physiology; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, GABA-A - metabolism; Synapses - drug effects; Synapses - physiology; Temperature; THIP; Time Factors; Traumatic brain injury; Traumatic brain injury; GABA A receptor; mIPSCs; Tonic currents; Synaptic currents; THIP; Diazepam; Furosemide; Dentate granule cells; Bicuculline

Abstract Traumatic brain injury (TBI) can result in altered inhibitory neurotransmission, hippocampal dysfunction, and cognitive impairments. GABAergic spontaneous and miniature inhibitory postsynaptic currents (sIPSCs and mIPSCs) and tonic (extrasynaptic) whole cell currents were recorded in contro...