Synthesis and Configurations of (-)-Furospongin-1 and (+)-Dihydrofuro­spongin-2

• Published in: European journal of organic chemistry Vol. 2016; no. 5; pp. 946 - 957
• Main Authors: Tan, Dong-Xing, Xu, Ze-Jun, Chen, Hui-Jun, Wu, Yikang, You, Jun
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01.02.2016; WILEY‐VCH Verlag; Wiley Subscription Services, Inc
• Subjects: Chiral pool; Configuration determination; Natural products; Oxygen heterocycles; Terpenes; Total synthesis

The long‐known furanoterpenes furospongin‐1 and dihydrofurospongin‐2 were synthesized for the first time using a chiral‐pool‐based route in an effort to secure the previous configurational assignments. The key C‐11 stereogenic centre was taken from D‐mannose, and the C‐13 alkyl centre was installed...