The mechanisms of regulation of vitamin D metabolism in the kidney

Recently, the 24-hydroxylase enzyme of 25-hydroxyvitamin D3 was purified from rat and chick kidney, and its complementary DNA was cloned. The length of the rat 24-hydroxylase gene is about 15 kbp with 12 exons. Cloning of the 24-hydroxylase gene made it possible to examine the mechanism of regulatio...

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Bibliographic Details
Published inCurrent opinion in nephrology and hypertension Vol. 3; no. 1; p. 59
Main Authors Suda, T, Shinki, T, Kurokawa, K
Format Journal Article
LanguageEnglish
Published England 01.01.1994
Subjects
Animals
Calcitriol - blood
Chickens
Cholestanetriol 26-Monooxygenase
Cloning, Molecular
Cytochrome P-450 Enzyme System - biosynthesis
Cytochrome P-450 Enzyme System - genetics
Exons
Gene Expression
Homeostasis
Humans
Kidney - metabolism
Parathyroid Hormone - blood
Rats
RNA, Messenger - analysis
RNA, Messenger - biosynthesis
Steroid Hydroxylases - biosynthesis
Steroid Hydroxylases - genetics
Steroid Hydroxylases - metabolism
Vitamin D - metabolism
Vitamin D3 24-Hydroxylase
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Summary:Recently, the 24-hydroxylase enzyme of 25-hydroxyvitamin D3 was purified from rat and chick kidney, and its complementary DNA was cloned. The length of the rat 24-hydroxylase gene is about 15 kbp with 12 exons. Cloning of the 24-hydroxylase gene made it possible to examine the mechanism of regulation of vitamin D metabolism at the gene level. Expression of renal 24-hydroxylase mRNA is regulated by a balance of plasma parathyroid hormone and 1 alpha,25-dihydroxyvitamin D3 levels, whereas intestinal 24-hydroxylase mRNA is regulated mainly by plasma 1 alpha,25-dihydroxyvitamin D3. This article reviews recent progress in understanding the molecular aspects of vitamin D metabolism.
ISSN:1062-4821
DOI:10.1097/00041552-199401000-00008