Angiotensin II–Independent Angiotensin-(1–7) Formation in Rat Hippocampus: Involvement of Thimet Oligopeptidase

• Published in: Hypertension (Dallas, Tex. 1979) Vol. 62; no. 5; pp. 879 - 885
• Main Authors: Pereira, Marilia G.A.G, Souza, Laura L, Becari, Christiane, Duarte, Diego A, Camacho, Fabio R.B, Oliveira, José Antônio C, Gomes, Marcelo D, Oliveira, Eduardo B, Salgado, Maria Cristina O, Garcia-Cairasco, Norberto, Costa-Neto, Claudio M
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD American Heart Association, Inc 01.11.2013; Lippincott Williams & Wilkins
• Subjects: Angiotensin I - biosynthesis; Animals; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Epilepsy - metabolism; Female; Hippocampus - metabolism; Medical sciences; Metalloendopeptidases - metabolism; Peptide Fragments - biosynthesis; Proto-Oncogene Proteins - metabolism; Rats; Rats, Wistar; Receptors, G-Protein-Coupled - metabolism; Renin-Angiotensin System - physiology; Rat; Peptide hormone; Central nervous system; Metalloendopeptidases; Cardiovascular disease; Encephalon; Octapeptide; renin―angiotensin system; Tumor; Angiotensin II; Biological receptor; Hypertension; Enzyme; Rodentia; Thimet oligopeptidase; Mass; Peptidases; Vertebrata; Renin angiotensin system; Mammalia; Animal; angiotensin-(1―7); Hydrolases; Circulatory system; Formation; angiotensin-(1―7) receptor Mas; angiotensins; Hippocampus; angiotensin-(1–7); renin–angiotensin system; angiotensin-(1–7) receptor Mas; central nervous system; thimet oligopeptidase

The involvement and relevance of the renin–angiotensin system have been established clearly in cardiovascular diseases, and renin–angiotensin system involvement has also been investigated extensively in the central nervous system. Angiotensin II acts classically by binding to the AT1 and AT2 recepto...