Angiotensin II–Independent Angiotensin-(1–7) Formation in Rat Hippocampus: Involvement of Thimet Oligopeptidase
The involvement and relevance of the renin–angiotensin system have been established clearly in cardiovascular diseases, and renin–angiotensin system involvement has also been investigated extensively in the central nervous system. Angiotensin II acts classically by binding to the AT1 and AT2 recepto...
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Published in | Hypertension (Dallas, Tex. 1979) Vol. 62; no. 5; pp. 879 - 885 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Hagerstown, MD
American Heart Association, Inc
01.11.2013
Lippincott Williams & Wilkins |
Subjects | |
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Abstract | The involvement and relevance of the renin–angiotensin system have been established clearly in cardiovascular diseases, and renin–angiotensin system involvement has also been investigated extensively in the central nervous system. Angiotensin II acts classically by binding to the AT1 and AT2 receptors. However, other pathways within the renin–angiotensin system have been described more recently, such as one in which angiotensin-(1–7) (Ang-(1–7)) binds to the receptor Mas. In the central nervous system specifically, it has been reported that this heptapeptide is involved in learning and memory processes that occur in central limbic regions, such as the hippocampus. Therefore, this prompted us to investigate the possible role of the Ang-(1–7)–receptor Mas pathway in epileptic seizures, which are also known to recruit limbic areas. In the present study, we show that Ang-(1–7) is the main metabolite of angiotensin I in rat hippocampi, and, strikingly, that thimet oligopeptidase is the main enzyme involved in the generation of Ang-(1–7). Furthermore, elevations in the levels of thimet oligopeptidase, Ang-(1–7), and of receptor Mas transcripts are observed in chronically stimulated epileptic rats, which suggest that the thimet oligopeptidase–Ang-(1–7)–receptor Mas axis may have a functional relevance in the pathophysiology of these animals. In summary, our data, which describe a new preferential biochemical pathway for the generation of Ang-(1–7) in the central nervous system and an increase in the levels of various elements of the related thimet oligopeptidase–Ang-(1–7)–receptor Mas pathway, unveil potential new roles of the renin–angiotensin system in central nervous system pathophysiology. |
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AbstractList | The involvement and relevance of the renin-angiotensin system have been established clearly in cardiovascular diseases, and renin-angiotensin system involvement has also been investigated extensively in the central nervous system. Angiotensin II acts classically by binding to the AT1 and AT2 receptors. However, other pathways within the renin-angiotensin system have been described more recently, such as one in which angiotensin-(1-7) (Ang-(1-7)) binds to the receptor Mas. In the central nervous system specifically, it has been reported that this heptapeptide is involved in learning and memory processes that occur in central limbic regions, such as the hippocampus. Therefore, this prompted us to investigate the possible role of the Ang-(1-7)-receptor Mas pathway in epileptic seizures, which are also known to recruit limbic areas. In the present study, we show that Ang-(1-7) is the main metabolite of angiotensin I in rat hippocampi, and, strikingly, that thimet oligopeptidase is the main enzyme involved in the generation of Ang-(1-7). Furthermore, elevations in the levels of thimet oligopeptidase, Ang-(1-7), and of receptor Mas transcripts are observed in chronically stimulated epileptic rats, which suggest that the thimet oligopeptidase-Ang-(1-7)-receptor Mas axis may have a functional relevance in the pathophysiology of these animals. In summary, our data, which describe a new preferential biochemical pathway for the generation of Ang-(1-7) in the central nervous system and an increase in the levels of various elements of the related thimet oligopeptidase-Ang-(1-7)-receptor Mas pathway, unveil potential new roles of the renin-angiotensin system in central nervous system pathophysiology. The involvement and relevance of the renin–angiotensin system have been established clearly in cardiovascular diseases, and renin–angiotensin system involvement has also been investigated extensively in the central nervous system. Angiotensin II acts classically by binding to the AT 1 and AT 2 receptors. However, other pathways within the renin–angiotensin system have been described more recently, such as one in which angiotensin-(1–7) (Ang-(1–7)) binds to the receptor Mas. In the central nervous system specifically, it has been reported that this heptapeptide is involved in learning and memory processes that occur in central limbic regions, such as the hippocampus. Therefore, this prompted us to investigate the possible role of the Ang-(1–7)–receptor Mas pathway in epileptic seizures, which are also known to recruit limbic areas. In the present study, we show that Ang-(1–7) is the main metabolite of angiotensin I in rat hippocampi, and, strikingly, that thimet oligopeptidase is the main enzyme involved in the generation of Ang-(1–7). Furthermore, elevations in the levels of thimet oligopeptidase, Ang-(1–7), and of receptor Mas transcripts are observed in chronically stimulated epileptic rats, which suggest that the thimet oligopeptidase–Ang-(1–7)–receptor Mas axis may have a functional relevance in the pathophysiology of these animals. In summary, our data, which describe a new preferential biochemical pathway for the generation of Ang-(1–7) in the central nervous system and an increase in the levels of various elements of the related thimet oligopeptidase–Ang-(1–7)–receptor Mas pathway, unveil potential new roles of the renin–angiotensin system in central nervous system pathophysiology. |
Author | Becari, Christiane Garcia-Cairasco, Norberto Gomes, Marcelo D Oliveira, Eduardo B Pereira, Marilia G.A.G Camacho, Fabio R.B Oliveira, José Antônio C Salgado, Maria Cristina O Duarte, Diego A Costa-Neto, Claudio M Souza, Laura L |
AuthorAffiliation | From the Department of Biochemistry and Immunology (M.G.A.G.P., L.L.S., D.A.D., F.R.B.C., M.D.G., E.B.O, C.M.C.-N.), Department of Pharmacology (C.B., M.C.O.S.), and Department of Physiology (J.A.C.O., N.G.-C.), Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, Brazil |
AuthorAffiliation_xml | – name: From the Department of Biochemistry and Immunology (M.G.A.G.P., L.L.S., D.A.D., F.R.B.C., M.D.G., E.B.O, C.M.C.-N.), Department of Pharmacology (C.B., M.C.O.S.), and Department of Physiology (J.A.C.O., N.G.-C.), Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, Brazil |
Author_xml | – sequence: 1 givenname: Marilia surname: Pereira middlename: G.A.G fullname: Pereira, Marilia G.A.G organization: From the Department of Biochemistry and Immunology (M.G.A.G.P., L.L.S., D.A.D., F.R.B.C., M.D.G., E.B.O, C.M.C.-N.), Department of Pharmacology (C.B., M.C.O.S.), and Department of Physiology (J.A.C.O., N.G.-C.), Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, Brazil – sequence: 2 givenname: Laura surname: Souza middlename: L fullname: Souza, Laura L – sequence: 3 givenname: Christiane surname: Becari fullname: Becari, Christiane – sequence: 4 givenname: Diego surname: Duarte middlename: A fullname: Duarte, Diego A – sequence: 5 givenname: Fabio surname: Camacho middlename: R.B fullname: Camacho, Fabio R.B – sequence: 6 givenname: José Antônio surname: Oliveira middlename: C fullname: Oliveira, José Antônio C – sequence: 7 givenname: Marcelo surname: Gomes middlename: D fullname: Gomes, Marcelo D – sequence: 8 givenname: Eduardo surname: Oliveira middlename: B fullname: Oliveira, Eduardo B – sequence: 9 givenname: Maria Cristina surname: Salgado middlename: O fullname: Salgado, Maria Cristina O – sequence: 10 givenname: Norberto surname: Garcia-Cairasco fullname: Garcia-Cairasco, Norberto – sequence: 11 givenname: Claudio surname: Costa-Neto middlename: M fullname: Costa-Neto, Claudio M |
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Cites_doi | 10.1016/0006-8993(92)90517-D 10.1111/j.1471-4159.2004.02557.x 10.1161/01.HYP.0000178157.70142.33 10.1111/j.1432-1033.1983.tb07620.x 10.1016/j.mcn.2005.03.012 10.1016/j.peptides.2009.07.003 10.1007/s00109-008-0336-0 10.1074/jbc.273.19.11867 10.1016/S0920-1211(00)00107-8 10.1016/S0021-9258(19)84737-3 10.1161/01.HYP.11.2_Pt_2.I153 10.1016/S0167-0115(97)00015-3 10.1161/01.hyp.19.2_suppl.ii56 10.1161/hypertensionaha.106.076216 10.1016/S0306-4522(03)00191-X 10.1016/j.yjmcc.2010.12.003 10.1152/physrev.00036.2005 10.1016/0006-8993(71)90137-5 10.1042/CS20120111 10.1161/01.RES.87.5.e1 10.1016/j.regpep.2007.03.006 10.1016/j.nlm.2011.10.003 10.1161/01.HYP.19.6.692 10.1023/A:1021099432759 10.1073/pnas.1432869100 10.1161/01.hyp.0000178157.70142.33 10.1016/S0378-5955(02)00371-4 10.1021/bi002715k 10.1016/S0920-1211(96)00050-2 10.1042/CS20100053 10.1042/bj3450351 10.1007/s10741-007-9062-x 10.1016/j.peptides.2011.12.001 10.1016/j.neuroscience.2004.01.042 10.1074/jbc.M002615200 10.1017/S031716710003287X 10.2147/VHRM.S1905 10.1073/pnas.85.11.4095 |
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Keywords | Rat Peptide hormone Central nervous system Metalloendopeptidases Cardiovascular disease Encephalon Octapeptide renin―angiotensin system Tumor Angiotensin II Biological receptor Hypertension Enzyme Rodentia Thimet oligopeptidase Mass Peptidases Vertebrata Renin angiotensin system Mammalia Animal angiotensin-(1―7) Hydrolases Circulatory system Formation angiotensin-(1―7) receptor Mas angiotensins Hippocampus angiotensin-(1–7) renin–angiotensin system angiotensin-(1–7) receptor Mas central nervous system thimet oligopeptidase |
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References | e_1_3_4_3_2 e_1_3_4_2_2 e_1_3_4_9_2 e_1_3_4_7_2 e_1_3_4_6_2 e_1_3_4_40_2 e_1_3_4_5_2 e_1_3_4_4_2 e_1_3_4_22_2 e_1_3_4_23_2 e_1_3_4_20_2 e_1_3_4_21_2 e_1_3_4_26_2 e_1_3_4_27_2 e_1_3_4_24_2 Chappell MC (e_1_3_4_8_2) 1994; 5 e_1_3_4_25_2 e_1_3_4_28_2 e_1_3_4_29_2 e_1_3_4_30_2 e_1_3_4_11_2 e_1_3_4_34_2 e_1_3_4_12_2 e_1_3_4_33_2 e_1_3_4_32_2 e_1_3_4_10_2 e_1_3_4_31_2 e_1_3_4_15_2 e_1_3_4_38_2 e_1_3_4_16_2 e_1_3_4_37_2 e_1_3_4_13_2 e_1_3_4_36_2 e_1_3_4_14_2 e_1_3_4_35_2 e_1_3_4_19_2 e_1_3_4_17_2 e_1_3_4_18_2 e_1_3_4_39_2 |
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SubjectTerms | Angiotensin I - biosynthesis Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Epilepsy - metabolism Female Hippocampus - metabolism Medical sciences Metalloendopeptidases - metabolism Peptide Fragments - biosynthesis Proto-Oncogene Proteins - metabolism Rats Rats, Wistar Receptors, G-Protein-Coupled - metabolism Renin-Angiotensin System - physiology |
Title | Angiotensin II–Independent Angiotensin-(1–7) Formation in Rat Hippocampus: Involvement of Thimet Oligopeptidase |
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