Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and transforming growth factor-β2/insulin-like growth factor-1-mediated regulation of the hair cycle in male and female human hair follicles in vitro

• Published in: British journal of dermatology (1951) Vol. 171; no. 5; pp. 1031 - 1043
• Main Authors: Fischer, T.W., Herczeg-Lisztes, E., Funk, W., Zillikens, D., Bíró, T., Paus, R.
• Format: Journal Article
• Language: English
• Published: Oxford Blackwell Publishing Ltd 01.11.2014; Wiley-Blackwell; Oxford University Press
• Subjects: Androgens - pharmacology; Antigens - metabolism; Apoptosis; Apoptosis - drug effects; Biological and medical sciences; Caffeine; Caffeine - pharmacology; Cell culture; Cell proliferation; Cell Proliferation - drug effects; Cells, Cultured; Dermatology; Elongation; Female; Follicles; Gene expression; Growth factors; Hair; Hair - drug effects; Hair - growth & development; Hair Follicle - drug effects; Histomorphometry; Humans; In Vitro Techniques; Insulin; Insulin-Like Growth Factor I - drug effects; Insulin-Like Growth Factor I - metabolism; Insulin-Like Growth Factor I - secretion; Insulin-like growth factors; Intermediate Filament Proteins - metabolism; Keratinocytes; Keratinocytes - drug effects; Male; Medical sciences; Organ culture; Phosphodiesterase Inhibitors - pharmacology; Protein expression; Proteins; Scalp; Testosterone; Testosterone - pharmacology; Transforming Growth Factor beta2 - drug effects; Transforming Growth Factor beta2 - metabolism; Transforming Growth Factor beta2 - secretion; Human; Cell proliferation; Hair; Root; CNS stimulant; Dermatology; Psychotropic; Hair follicle; Male; Outer; Keratinocyte growth factor; Proliferation; Insulin like growth factor 1; In vitro; Cycle; Sheath; Respiratory analeptic; Hair (head); Regulation(control); Transforming growth factor β2; Female; Caffeine

Summary Background Caffeine reportedly counteracts the suppression of hair shaft production by testosterone in organ‐cultured male human hair follicles (HFs). Objectives We aimed to investigate the impact of caffeine (i) on additional key hair growth parameters, (ii) on major hair growth regulatory...