Influence of iodide excess and interferon-gamma on human primary thyroid cell proliferation, thyroglobulin secretion, and intracellular adhesion molecule-1 and human leukocyte antigen-DR expression

• Published in: Thyroid (New York, N.Y.) Vol. 19; no. 3; p. 283
• Main Authors: Kostic, Irena, Toffoletto, Barbara, Fontanini, Elisabetta, Moretti, Massimo, Cesselli, Daniela, Beltrami, Carlo A, Ambesi Impiombato, Francesco S, Curcio, Francesco
• Format: Journal Article
• Language: English
• Published: United States 01.03.2009
• Subjects: Annexin A5 - biosynthesis; Cell Cycle - drug effects; Cell Proliferation - drug effects; DNA, Neoplasm - biosynthesis; DNA, Neoplasm - genetics; Flow Cytometry; G2 Phase - drug effects; HLA-DR Antigens - biosynthesis; Humans; Intercellular Adhesion Molecule-1 - biosynthesis; Interferon-gamma - pharmacology; Iodides - pharmacology; Thyroglobulin - metabolism; Thyroid Gland - cytology; Thyroid Gland - drug effects
• ISSN: 1557-9077
• DOI: 10.1089/thy.2008.0295

The effect of iodide on thyroid cell proliferation and function in vivo or in cultured thyroid cells has been previously reported and is still controversial. The aim of this study was to clarify these conflicting results by examining if prolonged high iodide exposition with or without interferon (IF...