Development of an Enzyme-Linked Immune Sorbent Assay to Measure Nivolumab and Pembrolizumab Serum Concentrations

• Published in: Therapeutic drug monitoring Vol. 40; no. 5; p. 596
• Main Authors: Basak, Edwin A, Wijkhuijs, Annemarie J M, Mathijssen, Ron H J, Koolen, Stijn L W, Schreurs, Marco W J
• Format: Journal Article
• Language: English
• Published: United States 01.10.2018
• Subjects: Antibodies, Monoclonal, Humanized - analysis; Antibodies, Monoclonal, Humanized - blood; Calibration - standards; Enzyme-Linked Immunosorbent Assay - methods; Humans; Ipilimumab - immunology; Nivolumab - analysis; Nivolumab - blood; Nivolumab - immunology; Serum - chemistry

Treatment with monoclonal antibodies (mAbs) against programmed cell death protein 1 receptor is subject to high variation in treatment outcome among cancer patients. For these agents, no exposure-response (ER) relationships have been investigated in routine health care settings. However, ER relation...