S-(1,3-Dioxoisoindolin-2-yl)O,O‑diethyl phosphorothioate (SDDP): A practical electrophilic reagent for the phosphorothiolation of electron-rich compounds

• Published in: Chinese chemical letters Vol. 35; no. 5; pp. 109076 - 154
• Main Authors: Ma, Ze-Yuan, Xiao, Mei, Li, Cheng-Kun, Shoberu, Adedamola, Zou, Jian-Ping
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.05.2024; Key Laboratory of Organic Synthesis of Jiangsu Province,College of Chemistry and Chemical Engineering,Soochow University,Suzhou 215123,China
• Subjects: Electrophilic reagent; Electrophilic substitution; Phosphorothiolation; Electrophilic substitution; Electrophilic reagent; Phosphorothiolation

An efficient synthesis of the electrophilic reagent, S-(1,3-dioxoisoindolin-2-yl)O,O‑diethyl phosphorothioate (SDDP) is described. Moreover, the synthetic applications of SDDP wherein the transfer of the SP(O)(OEt)2 moiety occurs were investigated. In this manner, SDDP underwent facile SP(O)(OEt)2 t...