Structure-informed microbial population genetics elucidate selective pressures that shape protein evolution

• Published in: Science advances Vol. 9; no. 8; p. eabq4632
• Main Authors: Kiefl, Evan, Esen, Ozcan C, Miller, Samuel E, Kroll, Kourtney L, Willis, Amy D, Rappé, Michael S, Pan, Tao, Eren, A Murat
• Format: Journal Article
• Language: English
• Published: United States 24.02.2023
• Subjects: Base Sequence; Ecology; Evolution, Molecular; Genetic Variation; Genetics, Population; Oceans and Seas; Organic Chemicals

Comprehensive sampling of natural genetic diversity with metagenomics enables highly resolved insights into the interplay between ecology and evolution. However, resolving adaptive, neutral, or purifying processes of evolution from intrapopulation genomic variation remains a challenge, partly due to...