A microRNA-21-mediated SATB1/S100A9/NF-κB axis promotes chronic obstructive pulmonary disease pathogenesis

• Published in: Science translational medicine Vol. 13; no. 621; p. eaav7223
• Main Authors: Kim, Richard Y, Sunkara, Krishna P, Bracke, Ken R, Jarnicki, Andrew G, Donovan, Chantal, Hsu, Alan C, Ieni, Antonio, Beckett, Emma L, Galvão, Izabela, Wijnant, Sara, Ricciardolo, Fabio Lm, Di Stefano, Antonino, Haw, Tatt Jhong, Liu, Gang, Ferguson, Angela L, Palendira, Umamainthan, Wark, Peter A, Conickx, Griet, Mestdagh, Pieter, Brusselle, Guy G, Caramori, Gaetano, Foster, Paul S, Horvat, Jay C, Hansbro, Philip M
• Format: Journal Article
• Language: English
• Published: United States 24.11.2021
• Subjects: Animals; Calgranulin B - genetics; Calgranulin B - metabolism; Lung - pathology; Matrix Attachment Region Binding Proteins - genetics; Matrix Attachment Region Binding Proteins - metabolism; Mice; MicroRNAs - genetics; MicroRNAs - metabolism; NF-kappa B - metabolism; Pulmonary Disease, Chronic Obstructive - genetics; Pulmonary Disease, Chronic Obstructive - metabolism

Chronic obstructive pulmonary disease (COPD) is the third leading cause of morbidity and death worldwide. Inhalation of cigarette smoke (CS) is the major cause in developed countries. Current therapies have limited efficacy in controlling disease or halting its progression. Aberrant expression of mi...