The Influence of Plasma Albumin Concentration on the Analysis Methodology of Free Valproic Acid by Ultrafiltration and Its Application to Therapeutic Drug Monitoring

• Published in: Therapeutic drug monitoring Vol. 37; no. 6; p. 776
• Main Authors: Zhang, Zhi-Qing, Dong, Wei-Chong, Yang, Xiu-Ling, Zhang, Jin-Feng, Jiang, Xin-Hui, Jing, Shao-Jun, Yang, Hong-le, Jiang, Ye
• Format: Journal Article
• Language: English
• Published: United States 01.12.2015
• Subjects: Adolescent; Adult; Aged; Centrifugation - methods; Child; Child, Preschool; Drug Monitoring - methods; Female; Humans; Infant; Male; Middle Aged; Serum Albumin - metabolism; Ultrafiltration - methods; Valproic Acid - pharmacokinetics; Young Adult

Free drug analysis is increasingly becoming popular in therapeutic drug monitoring (TDM). Centrifugal ultrafiltration (CF-UF) is the primary method to separate free drug from that of bound drug. However, the volume ratio of ultrafiltrate to sample solution (Vu/Vs) affects the accuracy of CF-UF, whic...