Evidence that the anorexia induced by lipopolysaccharide is mediated by the 5-HT2C receptor
Rats consistently reduce their food intake following injections of bacterial lipopolysaccharides (LPS). Because inhibition of serotonergic (5-HT) activity by 8-OH-DPAT (5-HT(1A) activation) attenuates LPS-induced anorexia, we conducted a series of studies to examine whether other 5-HT-receptors are...
Saved in:
Published in | Pharmacology, biochemistry and behavior Vol. 74; no. 2; pp. 505 - 512 |
---|---|
Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
New York, NY
Elsevier Science
2003
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Rats consistently reduce their food intake following injections of bacterial lipopolysaccharides (LPS). Because inhibition of serotonergic (5-HT) activity by 8-OH-DPAT (5-HT(1A) activation) attenuates LPS-induced anorexia, we conducted a series of studies to examine whether other 5-HT-receptors are involved in the mediation of peripheral LPS-induced anorexia. In all experiments, rats were injected with LPS (100 microg/kg body weight [BW] ip) at lights out (hour 0). Antagonists were administered peripherally at hour 4, shortly after the onset of anorexia, which presumably follows the enhanced cytokine production after LPS. Food intake was then recorded during the subsequent 2 h or longer. 5-HT receptor antagonists cyanopindolol and SB 224289 (5-HT(1B)), ketanserin (5-HT(2A)), RS-102221 (5-HT(2C)), and metoclopramide (5-HT(3)) failed to attenuate LPS-induced anorexia. In contrast, both ritanserin (5-HT(2A/C)-receptor antagonist) (0.5 mg/kg BW) and SB 242084 (5-HT(2C)) (0.3 mg/kg BW) attenuated LPS-induced anorexia at doses that did not alter food intake in non-LPS-treated rats (all P<.01). Our results suggest that at least part of the anorexia following peripheral LPS administration is mediated through an enhanced 5-HT-ergic activity and the 5-HT(2C) receptor. |
---|---|
AbstractList | Rats consistently reduce their food intake following injections of bacterial lipopolysaccharides (LPS). Because inhibition of serotonergic (5-HT) activity by 8-OH-DPAT (5-HT(1A) activation) attenuates LPS-induced anorexia, we conducted a series of studies to examine whether other 5-HT-receptors are involved in the mediation of peripheral LPS-induced anorexia. In all experiments, rats were injected with LPS (100 microg/kg body weight [BW] ip) at lights out (hour 0). Antagonists were administered peripherally at hour 4, shortly after the onset of anorexia, which presumably follows the enhanced cytokine production after LPS. Food intake was then recorded during the subsequent 2 h or longer. 5-HT receptor antagonists cyanopindolol and SB 224289 (5-HT(1B)), ketanserin (5-HT(2A)), RS-102221 (5-HT(2C)), and metoclopramide (5-HT(3)) failed to attenuate LPS-induced anorexia. In contrast, both ritanserin (5-HT(2A/C)-receptor antagonist) (0.5 mg/kg BW) and SB 242084 (5-HT(2C)) (0.3 mg/kg BW) attenuated LPS-induced anorexia at doses that did not alter food intake in non-LPS-treated rats (all P<.01). Our results suggest that at least part of the anorexia following peripheral LPS administration is mediated through an enhanced 5-HT-ergic activity and the 5-HT(2C) receptor. Rats consistently reduce their food intake following injections of bacterial lipopolysaccharides (LPS). Because inhibition of serotonergic (5-HT) activity by 8-OH-DPAT (5-HT(1A) activation) attenuates LPS-induced anorexia, we conducted a series of studies to examine whether other 5-HT-receptors are involved in the mediation of peripheral LPS-induced anorexia. In all experiments, rats were injected with LPS (100 microg/kg body weight [BW] ip) at lights out (hour 0). Antagonists were administered peripherally at hour 4, shortly after the onset of anorexia, which presumably follows the enhanced cytokine production after LPS. Food intake was then recorded during the subsequent 2 h or longer. 5-HT receptor antagonists cyanopindolol and SB 224289 (5-HT(1B)), ketanserin (5-HT(2A)), RS-102221 (5-HT(2C)), and metoclopramide (5-HT(3)) failed to attenuate LPS-induced anorexia. In contrast, both ritanserin (5-HT(2A/C)-receptor antagonist) (0.5 mg/kg BW) and SB 242084 (5-HT(2C)) (0.3 mg/kg BW) attenuated LPS-induced anorexia at doses that did not alter food intake in non-LPS-treated rats (all P<.01). Our results suggest that at least part of the anorexia following peripheral LPS administration is mediated through an enhanced 5-HT-ergic activity and the 5-HT(2C) receptor. |
Author | HRUPKA, Brian J VON MEYENBURG, Claudia LANGHANS, Wolfgang |
Author_xml | – sequence: 1 givenname: Claudia surname: VON MEYENBURG fullname: VON MEYENBURG, Claudia organization: Department of Physiology and Animal Husbandry, Institute of Animal Sciences, Swiss Federal Institute of Technology, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland – sequence: 2 givenname: Wolfgang surname: LANGHANS fullname: LANGHANS, Wolfgang organization: Department of Physiology and Animal Husbandry, Institute of Animal Sciences, Swiss Federal Institute of Technology, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland – sequence: 3 givenname: Brian J surname: HRUPKA fullname: HRUPKA, Brian J organization: Department of Physiology and Animal Husbandry, Institute of Animal Sciences, Swiss Federal Institute of Technology, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland |
BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14831987$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/12479973$$D View this record in MEDLINE/PubMed |
BookMark | eNpFkctOwzAQRS0EoqXwCaBsQLAIzDiJnSxRxUuqxIKyYmFNHEc1SpNgp4j-Pe5DsBlvzvXonjlhh23XGsbOEW4RUNy9ARQYJ5DJa-A3gMCLOD9gY8xlEmco5SEb_yEjduL9JwCkXMhjNkKeyqKQyZh9PHzbyrTaRMOChjBMRG3nzI-lyLbVSpsqKtdRY_uu75q1J60X5EIksj5amsrSsCM2ySx-nvNp5Iw2_dC5U3ZUU-PN2f6dsPfHh_n0OZ69Pr1M72exTpJsiMuCy6xELQRRTTyhugIyFepUp5zzSuQlFBIJK8nTTHDBucASoQ7NQh-TTNjV7t_edV8r4we1tF6bpqHWdCuvJM9zIRACmO1A7TrvnalV7-yS3FohqI1VtbWqNsoUcLW1qvKQu9gvWJWh839qrzEAl3uAvKamdtRq6_-5NE-wCIf5BadugH8 |
CODEN | PBBHAU |
CitedBy_id | crossref_primary_10_1017_S0029665107005587 crossref_primary_10_1152_ajpregu_90655_2008 crossref_primary_10_1210_en_2015_2081 crossref_primary_10_1007_s11259_012_9544_8 crossref_primary_10_1016_j_brainres_2009_09_079 crossref_primary_10_1007_s11259_013_9581_y crossref_primary_10_1080_00071668_2016_1141173 crossref_primary_10_1016_j_physbeh_2019_02_011 crossref_primary_10_1007_s12576_012_0218_7 crossref_primary_10_1016_j_pbb_2007_01_009 crossref_primary_10_1080_02646830500381450 crossref_primary_10_1016_j_physbeh_2010_04_009 crossref_primary_10_1016_S0091_3057_03_00030_3 crossref_primary_10_1016_S0304_3940_03_00312_4 crossref_primary_10_1186_1471_230X_5_18 crossref_primary_10_1124_dmd_106_013649 crossref_primary_10_1016_j_neuropharm_2014_01_031 crossref_primary_10_1016_j_pbb_2011_04_006 crossref_primary_10_1016_j_peptides_2015_06_011 crossref_primary_10_1016_j_physbeh_2004_11_003 crossref_primary_10_1016_j_bbi_2006_01_006 crossref_primary_10_1016_j_neuropharm_2017_12_024 crossref_primary_10_1016_j_bbr_2014_08_065 crossref_primary_10_1038_tp_2015_109 crossref_primary_10_1007_s12576_013_0263_x crossref_primary_10_1517_14728222_8_1_15 crossref_primary_10_1021_jm401802f |
Cites_doi | 10.1007/BF02431539 10.1016/0166-4328(96)00066-6 10.1016/0306-4530(94)90010-8 10.1016/S1566-0702(00)00227-7 10.1016/S0006-8993(98)00643-X 10.1016/S0014-2999(96)00660-7 10.1016/0091-3057(93)90363-X 10.1016/S0028-3908(01)00063-6 10.1016/0196-9781(96)00016-2 10.1016/0091-3057(91)90325-V 10.1016/0091-3057(87)90127-4 10.1016/0014-2999(94)00766-Z 10.1096/fasebj.8.2.8119492 10.1016/0014-2999(88)90236-1 10.1016/S0091-3057(99)00225-7 10.1523/JNEUROSCI.18-14-05537.1998 10.1016/S0028-3908(97)00049-X 10.1159/000097204 10.1016/0028-3908(84)90098-4 10.1016/S0899-9007(96)80052-9 10.1007/s002130050952 10.1096/fasebj.2.2.3277884 10.1007/s002130000504 10.1016/0304-3940(93)90494-6 10.1016/S0091-3057(00)00463-9 10.1038/374542a0 10.1016/S0006-8993(99)01206-8 10.1007/BF00442252 10.1016/S0149-7634(99)00074-3 10.1016/0014-2999(87)90561-9 10.1097/00000421-199304000-00020 10.1016/0006-8993(95)01373-3 10.3109/07853890008998829 10.1016/S0028-3908(97)00038-5 10.1038/sj.bjp.0703443 10.1016/S0091-3057(98)00136-1 10.1111/j.1749-6632.1998.tb10218.x |
ContentType | Journal Article |
Copyright | 2003 INIST-CNRS |
Copyright_xml | – notice: 2003 INIST-CNRS |
DBID | IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
DOI | 10.1016/S0091-3057(02)01029-8 |
DatabaseName | Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
DatabaseTitleList | MEDLINE - Academic MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Psychology Pharmacy, Therapeutics, & Pharmacology |
EISSN | 1873-5177 |
EndPage | 512 |
ExternalDocumentID | 10_1016_S0091_3057_02_01029_8 12479973 14831987 |
Genre | Journal Article |
GroupedDBID | --- --K --M -DZ .GJ .~1 08R 0R~ 123 1B1 1RT 1~. 1~5 29O 4.4 41~ 457 4G. 53G 5RE 5VS 7-5 71M 8P~ 9JM AABNK AACTN AADPK AAEDT AAIAV AAIKJ AAKOC AALMO AALRI AAOAW AAPBV AAQFI AAQXK AATCM AAXLA AAXUO ABCQJ ABFLS ABFNM ABFRF ABGSF ABIVO ABMAC ABPIF ABPTK ABQIS ABUDA ABXDB ABYKQ ABZDS ACDAQ ACGFO ACGFS ACIUM ACRLP ADALY ADBBV ADEZE ADIYS ADUVX AEBSH AEFWE AEHWI AEKER AENEX AFKWA AFTJW AFXIZ AGHFR AGRDE AGUBO AGWIK AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC C45 CS3 DOVZS DU5 EBS EFJIC EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HLW HMQ HMT HVGLF HZ~ H~9 IHE IPNFZ IQODW J1W KOM LX3 M2V M34 M41 MO0 MOBAO N9A O-L O9- OAUVE OGGZJ OVD OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SBG SCC SDF SDG SDP SES SEW SNS SPCBC SPT SSN SSP SSU SSZ T5K TEORI WUQ XJT XPP YYP ZGI ~G- AAEDW AAXKI ABJNI ADMUD AFJKZ AKRWK CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
ID | FETCH-LOGICAL-c335t-b9275b1c66aafa23afd0aed1c4c4222d68b0971a1d72456262261b10f305426e3 |
ISSN | 0091-3057 |
IngestDate | Fri Aug 16 04:56:13 EDT 2024 Thu Sep 26 17:29:12 EDT 2024 Sat Sep 28 08:40:27 EDT 2024 Thu Nov 24 18:34:21 EST 2022 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 2 |
Keywords | Vertebrata Anorexia Intraperitoneal administration Mammalia Rat Serotonin Food intake Animal Rodentia Lipopolysaccharide 5-HT2C serotonin receptor |
Language | English |
License | CC BY 4.0 |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c335t-b9275b1c66aafa23afd0aed1c4c4222d68b0971a1d72456262261b10f305426e3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
PMID | 12479973 |
PQID | 72886610 |
PQPubID | 23479 |
PageCount | 8 |
ParticipantIDs | proquest_miscellaneous_72886610 crossref_primary_10_1016_S0091_3057_02_01029_8 pubmed_primary_12479973 pascalfrancis_primary_14831987 |
PublicationCentury | 2000 |
PublicationDate | 2003 2003-Jan 2003-1-00 20030101 |
PublicationDateYYYYMMDD | 2003-01-01 |
PublicationDate_xml | – year: 2003 text: 2003 |
PublicationDecade | 2000 |
PublicationPlace | New York, NY |
PublicationPlace_xml | – name: New York, NY – name: United States |
PublicationTitle | Pharmacology, biochemistry and behavior |
PublicationTitleAlternate | Pharmacol Biochem Behav |
PublicationYear | 2003 |
Publisher | Elsevier Science |
Publisher_xml | – name: Elsevier Science |
References | Blundell (10.1016/S0091-3057(02)01029-8_BIB1) 1984; 23 Homesley (10.1016/S0091-3057(02)01029-8_BIB17) 1993; 16 Tecott (10.1016/S0091-3057(02)01029-8_BIB38) 1995; 374 Grignaschi (10.1016/S0091-3057(02)01029-8_BIB12) 1995; 274 Hoyer (10.1016/S0091-3057(02)01029-8_BIB18) 1994; 46 Grignaschi (10.1016/S0091-3057(02)01029-8_BIB11) 1993; 152 Hewson (10.1016/S0091-3057(02)01029-8_BIB16) 1988; 145 Hrupka (10.1016/S0091-3057(02)01029-8_BIB19) 2001; 68 Langhans (10.1016/S0091-3057(02)01029-8_BIB25) 1996; 12 Simansky (10.1016/S0091-3057(02)01029-8_BIB34) 1996; 73 Vickers (10.1016/S0091-3057(02)01029-8_BIB41) 2000; 130 Faggioni (10.1016/S0091-3057(02)01029-8_BIB10) 1997; 273 MohanKumar (10.1016/S0091-3057(02)01029-8_BIB29) 1999; 824 Yang (10.1016/S0091-3057(02)01029-8_BIB43) 1999; 62 Hammer (10.1016/S0091-3057(02)01029-8_BIB15) 1990; 259 Rinaman (10.1016/S0091-3057(02)01029-8_BIB32) 1999; 277 Hrupka (10.1016/S0091-3057(02)01029-8_BIB20) 1991; 40 Sonti (10.1016/S0091-3057(02)01029-8_BIB35) 1996; 17 Currie (10.1016/S0091-3057(02)01029-8_BIB7) 1998; 803 Kennett (10.1016/S0091-3057(02)01029-8_BIB22) 1988; 96 Bonhaus (10.1016/S0091-3057(02)01029-8_BIB2) 1997; 36 Clifton (10.1016/S0091-3057(02)01029-8_BIB6) 2000; 152 Bonhaus (10.1016/S0091-3057(02)01029-8_BIB3) 1998; 861 Halford (10.1016/S0091-3057(02)01029-8_BIB14) 2000; 32 Grignaschi (10.1016/S0091-3057(02)01029-8_BIB13) 1996; 708 Lawton (10.1016/S0091-3057(02)01029-8_BIB26) 1993; 46 Clifton (10.1016/S0091-3057(02)01029-8_BIB5) 2000; 24 Neill (10.1016/S0091-3057(02)01029-8_BIB30) 1989; 97 Tilders (10.1016/S0091-3057(02)01029-8_BIB39) 1994; 19 Vickers (10.1016/S0091-3057(02)01029-8_BIB42) 2001; 41 Massi (10.1016/S0091-3057(02)01029-8_BIB28) 1987; 26 Vickers (10.1016/S0091-3057(02)01029-8_BIB40) 1999; 143 Rinaman (10.1016/S0091-3057(02)01029-8_BIB33) 2000; 85 Kennett (10.1016/S0091-3057(02)01029-8_BIB24) 1997; 36 Kennett (10.1016/S0091-3057(02)01029-8_BIB23) 1987; 141 Dunn (10.1016/S0091-3057(02)01029-8_BIB9) 1992; 261 Swiergiel (10.1016/S0091-3057(02)01029-8_BIB37) 2000; 65 Rietschel (10.1016/S0091-3057(02)01029-8_BIB31) 1994; 8 Huang (10.1016/S0091-3057(02)01029-8_BIB21) 1999; 276 Lucas (10.1016/S0091-3057(02)01029-8_BIB27) 1998; 18 Sugimoto (10.1016/S0091-3057(02)01029-8_BIB36) 1996; 316 Catania (10.1016/S0091-3057(02)01029-8_BIB4) 1995; 2 Dinarello (10.1016/S0091-3057(02)01029-8_BIB8) 1988; 2 |
References_xml | – volume: 96 start-page: 93 year: 1988 ident: 10.1016/S0091-3057(02)01029-8_BIB22 article-title: Evidence that hypophagia induced by mCPP and TFMPP requires 5-HT1C and 5-HT1B receptors; hypophagia induced by RU 24969 only requires 5-HT1B receptors publication-title: Psychopharmacology (Berlin) doi: 10.1007/BF02431539 contributor: fullname: Kennett – volume: 73 start-page: 37 year: 1996 ident: 10.1016/S0091-3057(02)01029-8_BIB34 article-title: Serotonergic control of the organization of feeding and satiety publication-title: Behav. Brain Res. doi: 10.1016/0166-4328(96)00066-6 contributor: fullname: Simansky – volume: 19 start-page: 209 year: 1994 ident: 10.1016/S0091-3057(02)01029-8_BIB39 article-title: Activation of the hypothalamus–pituitary–adrenal axis by bacterial endotoxins: routes and intermediate signals publication-title: Psychoneuroendocrinology doi: 10.1016/0306-4530(94)90010-8 contributor: fullname: Tilders – volume: 85 start-page: 98 year: 2000 ident: 10.1016/S0091-3057(02)01029-8_BIB33 article-title: Antagonism of central glucagon-like peptide-1 receptors enhances lipopolysaccharide-induced fever publication-title: Auton. Neurosci. doi: 10.1016/S1566-0702(00)00227-7 contributor: fullname: Rinaman – volume: 803 start-page: 212 year: 1998 ident: 10.1016/S0091-3057(02)01029-8_BIB7 article-title: 5-Hydroxytryptaminergic receptor agonists: effects on neuropeptide Y potentiation of feeding and respiratory quotient publication-title: Brain Res. doi: 10.1016/S0006-8993(98)00643-X contributor: fullname: Currie – volume: 316 start-page: 15 year: 1996 ident: 10.1016/S0091-3057(02)01029-8_BIB36 article-title: Effects of peripheral 5-HT2 and 5-HT3 receptor agonists on food intake in food-deprived and 2-deoxy-d-glucose-treated rats publication-title: Eur. J. Pharmacol. doi: 10.1016/S0014-2999(96)00660-7 contributor: fullname: Sugimoto – volume: 46 start-page: 349 year: 1993 ident: 10.1016/S0091-3057(02)01029-8_BIB26 article-title: 5-HT and carbohydrate suppression: effects of 5-HT antagonists on the action of d-fenfluramine and DOI publication-title: Pharmacol. Biochem. Behav. doi: 10.1016/0091-3057(93)90363-X contributor: fullname: Lawton – volume: 41 start-page: 200 year: 2001 ident: 10.1016/S0091-3057(02)01029-8_BIB42 article-title: Evidence that hypophagia induced by d-fenfluramine and d-norfenfluramine in the rat is mediated by 5-HT2C receptors publication-title: Neuropharmacology doi: 10.1016/S0028-3908(01)00063-6 contributor: fullname: Vickers – volume: 17 start-page: 517 year: 1996 ident: 10.1016/S0091-3057(02)01029-8_BIB35 article-title: Neuropeptide Y blocks and reverses interleukin-1β-induced anorexia in rats publication-title: Peptides doi: 10.1016/0196-9781(96)00016-2 contributor: fullname: Sonti – volume: 40 start-page: 83 year: 1991 ident: 10.1016/S0091-3057(02)01029-8_BIB20 article-title: ICS 205-930 and feeding responses to amino acid imbalance: a peripheral effect? publication-title: Pharmacol. Biochem. Behav. doi: 10.1016/0091-3057(91)90325-V contributor: fullname: Hrupka – volume: 26 start-page: 333 year: 1987 ident: 10.1016/S0091-3057(02)01029-8_BIB28 article-title: Effect of the 5HT2 antagonist ritanserin on food intake and on 5HT-induced anorexia in the rat publication-title: Pharmacol. Biochem. Behav. doi: 10.1016/0091-3057(87)90127-4 contributor: fullname: Massi – volume: 274 start-page: 221 year: 1995 ident: 10.1016/S0091-3057(02)01029-8_BIB12 article-title: The 5-HT1B receptor mediates the effect of d-fenfluramine on eating caused by intra-hypothalamic injection of neuropeptide Y publication-title: Eur. J. Pharmacol. doi: 10.1016/0014-2999(94)00766-Z contributor: fullname: Grignaschi – volume: 8 start-page: 217 year: 1994 ident: 10.1016/S0091-3057(02)01029-8_BIB31 article-title: Bacterial endotoxin: molecular relationships of structure to activity and function publication-title: FASEB J. doi: 10.1096/fasebj.8.2.8119492 contributor: fullname: Rietschel – volume: 145 start-page: 227 year: 1988 ident: 10.1016/S0091-3057(02)01029-8_BIB16 article-title: Ketanserin antagonises the anorectic effect of dl-fenfluramine in the rat publication-title: Eur. J. Pharmacol. doi: 10.1016/0014-2999(88)90236-1 contributor: fullname: Hewson – volume: 65 start-page: 531 year: 2000 ident: 10.1016/S0091-3057(02)01029-8_BIB37 article-title: Lack of evidence for a role of serotonin in interleukin-1-induced hypophagia publication-title: Pharmacol. Biochem. Behav. doi: 10.1016/S0091-3057(99)00225-7 contributor: fullname: Swiergiel – volume: 18 start-page: 5537 year: 1998 ident: 10.1016/S0091-3057(02)01029-8_BIB27 article-title: Absence of fenfluramine-induced anorexia and reduced c-Fos induction in the hypothalamus and central amygdaloid complex of serotonin 1B receptor knock-out mice publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.18-14-05537.1998 contributor: fullname: Lucas – volume: 36 start-page: 621 year: 1997 ident: 10.1016/S0091-3057(02)01029-8_BIB2 article-title: RS-102221: a novel high affinity and selective, 5-HT2C receptor antagonist publication-title: Neuropharmacology doi: 10.1016/S0028-3908(97)00049-X contributor: fullname: Bonhaus – volume: 46 start-page: 157 year: 1994 ident: 10.1016/S0091-3057(02)01029-8_BIB18 article-title: International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin) publication-title: Pharmacol. Rev. contributor: fullname: Hoyer – volume: 277 start-page: R582 year: 1999 ident: 10.1016/S0091-3057(02)01029-8_BIB32 article-title: Interoceptive stress activates glucagon-like peptide-1 neurons that project to the hypothalamus publication-title: Am. J. Physiol. contributor: fullname: Rinaman – volume: 2 start-page: 258 year: 1995 ident: 10.1016/S0091-3057(02)01029-8_BIB4 article-title: Endotoxin causes release of α-melanocyte-stimulating hormone in normal human subjects publication-title: Neuroimmunomodulation doi: 10.1159/000097204 contributor: fullname: Catania – volume: 23 start-page: 1537 year: 1984 ident: 10.1016/S0091-3057(02)01029-8_BIB1 article-title: Serotonin and appetite publication-title: Neuropharmacology doi: 10.1016/0028-3908(84)90098-4 contributor: fullname: Blundell – volume: 12 start-page: 303 year: 1996 ident: 10.1016/S0091-3057(02)01029-8_BIB25 article-title: Bacterial products and the control of ingestive behaviour: clinical implications publication-title: Nutrition doi: 10.1016/S0899-9007(96)80052-9 contributor: fullname: Langhans – volume: 143 start-page: 309 year: 1999 ident: 10.1016/S0091-3057(02)01029-8_BIB40 article-title: Reduced satiating effect of d-fenfluramine in serotonin 5-HT2C receptor mutant mice publication-title: Psychopharmacology (Berlin) doi: 10.1007/s002130050952 contributor: fullname: Vickers – volume: 2 start-page: 108 year: 1988 ident: 10.1016/S0091-3057(02)01029-8_BIB8 article-title: Biology of interleukin 1 publication-title: FASEB J. doi: 10.1096/fasebj.2.2.3277884 contributor: fullname: Dinarello – volume: 152 start-page: 256 year: 2000 ident: 10.1016/S0091-3057(02)01029-8_BIB6 article-title: Similarities in the action of Ro 60-0175, a 5-HT2C receptor agonist and d-fenfluramine on feeding patterns in the rat publication-title: Psychopharmacology (Berlin) doi: 10.1007/s002130000504 contributor: fullname: Clifton – volume: 273 start-page: R181 year: 1997 ident: 10.1016/S0091-3057(02)01029-8_BIB10 article-title: LPS-induced anorexia in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mice publication-title: Am. J. Physiol. contributor: fullname: Faggioni – volume: 152 start-page: 103 year: 1993 ident: 10.1016/S0091-3057(02)01029-8_BIB11 article-title: The hypophagic effect of restraint stress in rats can be mediated by 5-HT2 receptors in the paraventricular nucleus of the hypothalamus publication-title: Neurosci. Lett. doi: 10.1016/0304-3940(93)90494-6 contributor: fullname: Grignaschi – volume: 68 start-page: 355 year: 2001 ident: 10.1016/S0091-3057(02)01029-8_BIB19 article-title: A role for serotonin in lipopolysaccharide-induced anorexia in rats publication-title: Pharmacol. Biochem. Behav. doi: 10.1016/S0091-3057(00)00463-9 contributor: fullname: Hrupka – volume: 276 start-page: R864 year: 1999 ident: 10.1016/S0091-3057(02)01029-8_BIB21 article-title: Role of central melanocortins in endotoxin-induced anorexia publication-title: Am. J. Physiol. contributor: fullname: Huang – volume: 374 start-page: 542 year: 1995 ident: 10.1016/S0091-3057(02)01029-8_BIB38 article-title: Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors publication-title: Nature doi: 10.1038/374542a0 contributor: fullname: Tecott – volume: 824 start-page: 232 year: 1999 ident: 10.1016/S0091-3057(02)01029-8_BIB29 article-title: Lipopolysaccharide-induced changes in monoamines in specific areas of the brain: blockade by interleukin-1 receptor antagonist publication-title: Brain Res. doi: 10.1016/S0006-8993(99)01206-8 contributor: fullname: MohanKumar – volume: 97 start-page: 213 year: 1989 ident: 10.1016/S0091-3057(02)01029-8_BIB30 article-title: Evidence that d-fenfluramine anorexia is mediated by 5-HT1 receptors publication-title: Psychopharmacology (Berlin) doi: 10.1007/BF00442252 contributor: fullname: Neill – volume: 24 start-page: 213 year: 2000 ident: 10.1016/S0091-3057(02)01029-8_BIB5 article-title: Meal patterning in rodents: psychopharmacological and neuroanatomical studies publication-title: Neurosci. Biobehav. Rev. doi: 10.1016/S0149-7634(99)00074-3 contributor: fullname: Clifton – volume: 261 start-page: 964 year: 1992 ident: 10.1016/S0091-3057(02)01029-8_BIB9 article-title: Endotoxin-induced activation of cerebral catecholamine and serotonin metabolism: comparison with interleukin-1 publication-title: J. Pharmacol. Exp. Ther. contributor: fullname: Dunn – volume: 141 start-page: 429 year: 1987 ident: 10.1016/S0091-3057(02)01029-8_BIB23 article-title: 5-HT1B agonists induce anorexia at a postsynaptic site publication-title: Eur. J. Pharmacol. doi: 10.1016/0014-2999(87)90561-9 contributor: fullname: Kennett – volume: 16 start-page: 175 year: 1993 ident: 10.1016/S0091-3057(02)01029-8_BIB17 article-title: Randomized comparison of the antiemetic efficacy of a serotonin type 3 receptor antagonist (MDL 72,222) with a high-dose metoclopramide regimen publication-title: Am. J. Clin. Oncol. doi: 10.1097/00000421-199304000-00020 contributor: fullname: Homesley – volume: 708 start-page: 173 year: 1996 ident: 10.1016/S0091-3057(02)01029-8_BIB13 article-title: Stimulation of 5-HT2A receptors in the paraventricular hypothalamus attenuates neuropeptide Y-induced hyperphagia through activation of corticotropin releasing factor publication-title: Brain Res. doi: 10.1016/0006-8993(95)01373-3 contributor: fullname: Grignaschi – volume: 259 start-page: R627 year: 1990 ident: 10.1016/S0091-3057(02)01029-8_BIB15 article-title: Serotonin3 receptor antagonists block anorectic responses to amino acid imbalance publication-title: Am. J. Physiol. contributor: fullname: Hammer – volume: 32 start-page: 222 year: 2000 ident: 10.1016/S0091-3057(02)01029-8_BIB14 article-title: Separate systems for serotonin and leptin in appetite control publication-title: Ann. Med. doi: 10.3109/07853890008998829 contributor: fullname: Halford – volume: 36 start-page: 609 year: 1997 ident: 10.1016/S0091-3057(02)01029-8_BIB24 article-title: SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist publication-title: Neuropharmacology doi: 10.1016/S0028-3908(97)00038-5 contributor: fullname: Kennett – volume: 130 start-page: 1305 year: 2000 ident: 10.1016/S0091-3057(02)01029-8_BIB41 article-title: Comparative effects of continuous infusion of mCPP, Ro 60-0175 and d-fenfluramine on food intake, water intake, body weight and locomotor activity in rats publication-title: Br. J. Pharmacol. doi: 10.1038/sj.bjp.0703443 contributor: fullname: Vickers – volume: 62 start-page: 61 year: 1999 ident: 10.1016/S0091-3057(02)01029-8_BIB43 article-title: Interleukin-1α injection into ventromedial hypothalamic nucleus of normal rats depresses food intake and increases release of dopamine and serotonin publication-title: Pharmacol. Biochem. Behav. doi: 10.1016/S0091-3057(98)00136-1 contributor: fullname: Yang – volume: 861 start-page: 269 year: 1998 ident: 10.1016/S0091-3057(02)01029-8_BIB3 article-title: Absorption and brain penetration of a high affinity, highly selective 5-HT2C receptor antagonist, RS-102221 publication-title: Ann. N.Y. Acad. Sci. doi: 10.1111/j.1749-6632.1998.tb10218.x contributor: fullname: Bonhaus |
SSID | ssj0004267 |
Score | 1.8839433 |
Snippet | Rats consistently reduce their food intake following injections of bacterial lipopolysaccharides (LPS). Because inhibition of serotonergic (5-HT) activity by... |
SourceID | proquest crossref pubmed pascalfrancis |
SourceType | Aggregation Database Index Database |
StartPage | 505 |
SubjectTerms | Adrenergic beta-Antagonists - pharmacology Adult and adolescent clinical studies Aminopyridines - pharmacology Animals Anorexia - chemically induced Anorexia - psychology Anorexia nervosa Biological and medical sciences Dopamine Antagonists - pharmacology Dose-Response Relationship, Drug Eating behavior disorders Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Indoles - pharmacology Lipopolysaccharides - pharmacology Male Medical sciences Metoclopramide - pharmacology Pindolol - analogs & derivatives Pindolol - pharmacology Piperidones - pharmacology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Rats Rats, Sprague-Dawley Receptor, Serotonin, 5-HT2C Receptors, Serotonin - drug effects Ritanserin - pharmacology Serotonin Antagonists - pharmacology Spiro Compounds - pharmacology Sulfonamides - pharmacology Vertebrates: anatomy and physiology, studies on body, several organs or systems |
Title | Evidence that the anorexia induced by lipopolysaccharide is mediated by the 5-HT2C receptor |
URI | https://www.ncbi.nlm.nih.gov/pubmed/12479973 https://search.proquest.com/docview/72886610 |
Volume | 74 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3ZaxNBGB9ifSmIaL3iUedBitJu3J3dOfYxlmqoGktNtMWHZWYPCYQkNAkYH_xT_Fv95tpNrOIBYQnLzg7M77ffMfMdCD2JopgrXrBAVRUJkkhVgUgJOCsxlQljQlSmuv7bPusNk-MzetZqfV-LWlouVCf_-su8kv9BFe4BrjpL9h-QrV8KN-A_4AtXQBiuf4WxbwkK1qPNSdyXk-lF-WUk98HVXubWuhyPZroTwmouc51jBUN0F3OTMrJw9ieMpEFvAMsNArCc2QrEtdF60pS3NpCokW6zZfvEmcMHn-vv0fvwTteNPD_qvxiempSow7FcFqNaA7zp9l_1un0TNfhxOq4-S6c_Nb9Ohyevu5Z2Wvgcb-xLxM02mU-VcdJpXfymerPLVqTulFbiCh4HNHK9XJxIto17HPXImnylIV1T1dRGYF_SAnZD4n09Hdjqus6sjkQhaSAa1eeP-3_SiHWcIviKsd6VuYKuEg6eJMjLzrcmhAisG1eT1c7TZIg9byZ_GpJnbuIN2-faTM7hM6xs_5TfOzjG0BncQNedh4K7lm43Uauc7KA9x4HVAR40GXvzA7yH19mxg7Zrjbq6hT55gmJNULiU2BMUO4JitcKXCYpHc-wJqp_QIy1BsSfobTR8eTQ47AWum0eQxzFdBColnKooZ0zKSpJYVkUoyyLKk1xvQxZMKF3PTEYF14fxhIFjEKkorGARYaHL-A7amkwn5T2EBaiZCvxwlnCVFGCQUyVZAT-uhJCMtlHHr3M2s0VbsiaaEYDJNDBZSDIDTCbaaHcDjWaUI0AbPfbwZPB56UM1OSmny3nGiRBg44ZtdNei1owlCU9THt__08sfoG0TImo29h6ircXFsnwEpu5C7Rq-_QA6QqSO |
link.rule.ids | 315,786,790,4043,27956,27957,27958 |
linkProvider | Elsevier |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Evidence+that+the+anorexia+induced+by+lipopolysaccharide+is+mediated+by+the+5-HT2C+receptor&rft.jtitle=Pharmacology%2C+biochemistry+and+behavior&rft.au=VON+MEYENBURG%2C+Claudia&rft.au=LANGHANS%2C+Wolfgang&rft.au=HRUPKA%2C+Brian+J&rft.date=2003&rft.pub=Elsevier+Science&rft.issn=0091-3057&rft.eissn=1873-5177&rft.volume=74&rft.issue=2&rft.spage=505&rft.epage=512&rft_id=info:doi/10.1016%2FS0091-3057%2802%2901029-8&rft.externalDBID=n%2Fa&rft.externalDocID=14831987 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0091-3057&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0091-3057&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0091-3057&client=summon |