Glutamine promotes antibiotic uptake to kill multidrug-resistant uropathogenic bacteria

• Published in: Science translational medicine Vol. 13; no. 625; p. eabj0716
• Main Authors: Zhao, Xian-Liang, Chen, Zhuang-Gui, Yang, Tian-Ci, Jiang, Ming, Wang, Jie, Cheng, Zhi-Xue, Yang, Man-Jun, Zhu, Jia-Xin, Zhang, Tian-Tuo, Li, Hui, Peng, Bo, Peng, Xuan-Xian
• Format: Journal Article
• Language: English
• Published: United States 22.12.2021
• Subjects: Animals; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Bacteria; Drug Resistance, Multiple, Bacterial; Escherichia coli; Glutamine; Mice; Microbial Sensitivity Tests

The prevalence of multidrug-resistant bacteria has been increasing rapidly worldwide, a trend that poses great risk to human and animal health and creates urgent need for pharmaceutical and nonpharmaceutical approaches to stop the spread of disease due to antimicrobial resistance. Here, we found tha...