Bioactive gelatin cryogels with BMP‐2 biomimetic peptide and VEGF: A potential scaffold for synergistically induced osteogenesis

• Published in: Chinese chemical letters Vol. 33; no. 4; pp. 1956 - 1962
• Main Authors: Wang, Lili, Chen, Long, Wang, Jiping, Wang, Liying, Gao, Chenyu, Li, Bo, Wang, Yuanzheng, Wu, Jun, Quan, Changyun
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.04.2022; Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instruments,School of Biomedical Engineering,Sun Yat-sen University,Shenzhen 518107,China%Department of Orthopedics,Guizhou Provincial People's Hospital,Guiyang 550000,China%School of Public Health,Yale University,New Haven,CT 06510,United States%Department of Biomedical Engineering,Johns Hopkins University,Baltimore,MD 21218,United States
• Subjects: Bioactive; Cryogel; Cytokine combination; Gelatin; Osteogenesis; Cytokine combination; Gelatin; Bioactive; Cryogel; Osteogenesis

A poor biocompatibility and bioactivity of invasive materials remains major problems for biomaterial-based therapy. In this study, we introduced gelatin scaffolds carrying both bone morphogenetic protein-2 (BMP-2) biomimetic peptide and vascular endothelial growth factor-165 (VEGF) that achieved con...