Acid-resistant ROS-responsive hyperbranched polythioether micelles for ulcerative colitis therapy

• Published in: Chinese chemical letters Vol. 31; no. 12; pp. 3102 - 3106
• Main Authors: Shi, Haitong, Zhao, Xiaoye, Gao, Jushan, Liu, Zhongwen, Liu, Zhaotie, Wang, Ke, Jiang, Jinqiang
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.12.2020; Key Laboratory of Syngas Conversion of Shaanxi Province, Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710062, China%School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China
• Subjects: Acid-resistant; Bud; Colon-targeting; Hyperbranched micelle; PCR; ROS responsive; Bud; Hyperbranched micelle; ROS responsive; Acid-resistant; Colon-targeting; PCR

We reported an acid-resistant ROS-responsive hyperbranched polythioether which can self-assemble into micellar structure and pass through the gastrointestinal tract without leaking drugs. [Display omitted] Drug-loaded micelles for oral administration are desired for its convenience, low cost and fle...