Biomaterial-induced macrophage polarization for bone regeneration

• Published in: Chinese chemical letters Vol. 34; no. 6; pp. 107925 - 171
• Main Authors: Chen, Long, Yao, Zhicheng, Zhang, Siqin, Tang, Kuihan, Yang, Qiming, Wang, Yuanzheng, Li, Bohan, Nie, Yingjie, Tian, Xiaobin, Sun, Li
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.06.2023; Department of Orthopedics,Guizhou Provincial People's Hospital,Guiyang 550000,China; The Central Laboratory,Guizhou Provincial People's Hospital,Guiyang 550000,China%Department of Orthopedics,The Affiliated Hospital of Guizhou Medical University,Guiyang 550000,China; Medical College,Guizhou University,Guiyang 550000,China%Department of Materials Science and Engineering,Translational Tissue Engineering Center,Johns Hopkins University,Baltimore,MD 21218,United States%Department of Endocrinology and Metabolism,Guizhou Provincial People's Hospital,Guiyang 550000,China%Department of Orthopedics,Guizhou Provincial People's Hospital,Guiyang 550000,China%Medical College,Guizhou University,Guiyang 550000,China
• Subjects: Biomaterial; Bone regeneration; Immune response; Macrophage polarization; Nano materials; Biomaterial; Immune response; Macrophage polarization; Bone regeneration; Nano materials

As the main target cells of immune regulation, macrophages play an important role in the bone regeneration process. Macrophages can be polarized into the M1 and M2 types under the stimulation of different factors. They have proinflammatory and anti-inflammatory effects, respectively, and play key ro...