Long-gap peripheral nerve repair through sustained release of a neurotrophic factor in nonhuman primates

• Published in: Science translational medicine Vol. 12; no. 527
• Main Authors: Fadia, Neil B, Bliley, Jacqueline M, DiBernardo, Gabriella A, Crammond, Donald J, Schilling, Benjamin K, Sivak, Wesley N, Spiess, Alexander M, Washington, Kia M, Waldner, Matthias, Liao, Han-Tsung, James, Isaac B, Minteer, Danielle M, Tompkins-Rhoades, Casey, Cottrill, Adam R, Kim, Deok-Yeol, Schweizer, Riccardo, Bourne, Debra A, Panagis, George E, Asher Schusterman, 2nd, M, Egro, Francesco M, Campwala, Insiyah K, Simpson, Tyler, Weber, Douglas J, Gause, 2nd, Trent, Brooker, Jack E, Josyula, Tvisha, Guevara, Astrid A, Repko, Alexander J, Mahoney, Christopher M, Marra, Kacey G
• Format: Journal Article
• Language: English
• Published: United States 22.01.2020
• Subjects: Animals; Axons - drug effects; Axons - metabolism; Delayed-Action Preparations; Glial Cell Line-Derived Neurotrophic Factor - administration & dosage; Glial Cell Line-Derived Neurotrophic Factor - chemistry; Glial Cell Line-Derived Neurotrophic Factor - pharmacology; Macaca; Nerve Regeneration - drug effects; Nerve Regeneration - physiology; Schwann Cells - drug effects; Schwann Cells - metabolism

Severe injuries to peripheral nerves are challenging to repair. Standard-of-care treatment for nerve gaps >2 to 3 centimeters is autografting; however, autografting can result in neuroma formation, loss of sensory function at the donor site, and increased operative time. To address the need for a...