Intercalation assembly of kojic acid into Zn-Ti layered double hydroxide with antibacterial and whitening performances

• Published in: Chinese chemical letters Vol. 30; no. 4; pp. 919 - 923
• Main Authors: Wang, Xin-Rui, Cheng, Hui-Min, Gao, Xue-Wei, Zhou, Wei, Li, Shu-Jing, Cao, Xue-Li, Yan, Dongpeng
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.04.2019; Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing 100048, China%Department of Chemistry, Beijing Normal University, Beijing 100875, China
• Subjects: Antimicrobial; Intercalation; Kojic acid; Layered double hydroxide; Slow release; Tyrosinase; Antimicrobial; Slow release; Intercalation; Layered double hydroxide; Kojic acid; Tyrosinase
• ISSN: 1001-8417; 1878-5964
• DOI: 10.1016/j.cclet.2019.03.050

The inhibitor of melanin and the bacteriostatic agent kojic acid was inserted into Zn-Ti layered double hydroxide (LDH) by anion-exchange reaction. The structure, slow release, antibacterial and skin whitening activity were studied. [Display omitted] A melanin synthesis inhibitor and bacteriostatic agent, kojic acid (KA) has been intercalated into Zn-Ti layered double hydroxide (LDH) by an anion-exchange reaction. The structure and the thermal stability of the samples were characterized by XRD, FT-IR, TG-DTA and SEM. The study of KA release from ZnTi-KA-LDH in phosphate buffered solution (pH 5) implies that ZnTi-KA-LDH is a better controlled release system than pure KA. Meanwhile, the mechanisms of slow release were assessed by using four commonly kinetic models. The antimicrobial activity of ZnTi-KA-LDH was tested against three kinds of bacteria. The inhibition of l-dopa oxidation was tested to verify its skin whitening effect. The studies suggest that the kojic acid intercalated LDHs has the potential application as a safely functional composite in cosmetic.