cGAS-STING-mediated DNA sensing maintains CD8 + T cell stemness and promotes antitumor T cell therapy

• Published in: Science translational medicine Vol. 12; no. 549
• Main Authors: Li, Wenwen, Lu, Lu, Lu, Juanjuan, Wang, Xinran, Yang, Chao, Jin, Jingsi, Wu, Lingling, Hong, Xiaochuan, Li, Fanlin, Cao, Dongqing, Yang, Yuanqin, Wu, Meng, Su, Bing, Cheng, Jinke, Yang, Xuanming, Di, Wen, Deng, Liufu
• Format: Journal Article
• Language: English
• Published: United States 24.06.2020

Although cGAS-STING-mediated DNA sensing in tumor cells or phagocytes is central for launching antitumor immunity, the role of intrinsic cGAS-STING activation in T cells remains unknown. Here, we observed that peripheral blood CD8 T cells from patients with cancer showed remarkably compromised expre...