Hyperbenzones A and B, two 1,2-seco and rearranged polycyclic polyprenylated acylphloroglucinols from Hypericum beanii

• Published in: Chinese chemical letters Vol. 33; no. 8; pp. 4121 - 4125
• Main Authors: Lu, Weijia, Zhang, Yanqiu, Li, Yawei, Ye, Shengtao, Luo, Jun, Kong, Lingyi, Xu, Wenjun
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.08.2022; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines,School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 210009,China
• Subjects: 1,2-seco-Bicyclic derivatives; Hyperbenzones A and B; Hypericum beanii; NASH; seco-PPAPs; 1,2-seco-Bicyclic derivatives; seco-PPAPs; Hypericum beanii; Hyperbenzones A and B; NASH

Two novel seco-polycyclic polyprenylated acylphloroglucinols (PPAPs), hyperbenzones A (1) and B (2), were isolated from the roots of Hypericum beanii, together with one known biosynthetic congener 3. Compound 1 incorporates a 6/5/5 ring system with an unprecedented spiro[bicyclo[3.3.0]octane-3,1ʹ-cy...