Full synthesis and bioactivity evaluation of Tn-RC-529 derivative conjugates as self-adjuvanting cancer vaccines

Tn-based vaccines carried by RC-529 derivatives were synthesized and elicited strongly T cell-dependent immune responses without external adjuvants. The antisera induced by these conjugates could specifically recognize, bind to and kill Tn-overexpressing cancer cells. [Display omitted] A facile and...

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Published inChinese chemical letters Vol. 32; no. 10; pp. 3011 - 3014
Main Authors Gao, Lingqiang, Lian, Qinghai, Ma, Leilei, Su, Shiwei, Yang, Menglan, Fang, Yuan, Liu, Zhongqiu, Luo, Xiang, Liao, Guochao
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.10.2021
Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education,International Institute for Translational Chinese Medicine,Guangzhou University of Chinese Medicine,Guangzhou 510006,China
Subjects
Cancer vaccines
Glycoconjugates
RC-529
Tn antigen
Cancer vaccines
RC-529
Tn antigen
Glycoconjugates
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Abstract Tn-based vaccines carried by RC-529 derivatives were synthesized and elicited strongly T cell-dependent immune responses without external adjuvants. The antisera induced by these conjugates could specifically recognize, bind to and kill Tn-overexpressing cancer cells. [Display omitted] A facile and efficient strategy was established for the construction of RC-529 and its derivatives. Four conjugates of RC-529 derivatives with Tn antigen were synthesized and all elicited strong and T cell-dependent immune responses in mice without requiring external adjuvants. In addition, all antisera induced by these conjugates could specifically recognize, bind to and kill Tn-overexpressing cancer cells. Thus, RC-529 shows promise as a useful platform for the development of new vaccine carriers with self-adjuvanting properties for the treatment of cancer. Moreover, preliminary structure-activity relationship analysis provides convincing support for further optimization of, and additional investigation into, RC-529.
AbstractList Tn-based vaccines carried by RC-529 derivatives were synthesized and elicited strongly T cell-dependent immune responses without external adjuvants. The antisera induced by these conjugates could specifically recognize, bind to and kill Tn-overexpressing cancer cells. [Display omitted] A facile and efficient strategy was established for the construction of RC-529 and its derivatives. Four conjugates of RC-529 derivatives with Tn antigen were synthesized and all elicited strong and T cell-dependent immune responses in mice without requiring external adjuvants. In addition, all antisera induced by these conjugates could specifically recognize, bind to and kill Tn-overexpressing cancer cells. Thus, RC-529 shows promise as a useful platform for the development of new vaccine carriers with self-adjuvanting properties for the treatment of cancer. Moreover, preliminary structure-activity relationship analysis provides convincing support for further optimization of, and additional investigation into, RC-529.
A facile and efficient strategy was established for the construction of RC-529 and its derivatives.Four conjugates of RC-529 derivatives with Tn antigen were synthesized and all elicited strong and T cell-dependent immune responses in mice without requiring external adjuvants.In addition,all antisera induced by these conjugates could specifically recognize,bind to and kill Tn-overexpressing cancer cells.Thus,RC-529 shows promise as a useful platform for the development of new vaccine carriers with self-adjuvanting properties for the treatment of cancer.Moreover,preliminary structure-activity relationship analysis provides convincing support for further optimization of,and additional investigation into RC-529.
Author Gao, Lingqiang
Luo, Xiang
Liao, Guochao
Su, Shiwei
Lian, Qinghai
Ma, Leilei
Fang, Yuan
Yang, Menglan
Liu, Zhongqiu
AuthorAffiliation Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education,International Institute for Translational Chinese Medicine,Guangzhou University of Chinese Medicine,Guangzhou 510006,China
AuthorAffiliation_xml – name: Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education,International Institute for Translational Chinese Medicine,Guangzhou University of Chinese Medicine,Guangzhou 510006,China
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Keywords Cancer vaccines
RC-529
Tn antigen
Glycoconjugates
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Snippet Tn-based vaccines carried by RC-529 derivatives were synthesized and elicited strongly T cell-dependent immune responses without external adjuvants. The...
A facile and efficient strategy was established for the construction of RC-529 and its derivatives.Four conjugates of RC-529 derivatives with Tn antigen were...
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SubjectTerms Cancer vaccines
Glycoconjugates
RC-529
Tn antigen
Title Full synthesis and bioactivity evaluation of Tn-RC-529 derivative conjugates as self-adjuvanting cancer vaccines
URI https://dx.doi.org/10.1016/j.cclet.2021.03.046
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