GPR177 in A-fiber sensory neurons drives diabetic neuropathic pain via WNT-mediated TRPV1 activation

• Published in: Science translational medicine Vol. 14; no. 639; p. eabh2557
• Main Authors: Xie, Ya-Kai, Luo, Hao, Zhang, Shan-Xin, Chen, Xiao-Ying, Guo, Ran, Qiu, Xiao-Yun, Liu, Shuai, Wu, Hui, Chen, Wen-Bo, Zhen, Xing-Hua, Ma, Qiang, Tian, Jin-Lan, Li, Shun, Chen, Xinzhong, Han, Qingjian, Duan, Shumin, Shen, Chengyong, Yang, Fan, Xu, Zhen-Zhong
• Format: Journal Article
• Language: English
• Published: United States 06.04.2022
• Subjects: Animals; Diabetes Mellitus - metabolism; Diabetic Neuropathies - metabolism; Ganglia, Spinal - metabolism; Humans; Intracellular Signaling Peptides and Proteins - metabolism; Mice; Neuralgia - metabolism; Receptors, G-Protein-Coupled - metabolism; Sensory Receptor Cells - metabolism; TRPV Cation Channels - metabolism; Wnt-5a Protein - metabolism
• ISSN: 1946-6242
• DOI: 10.1126/scitranslmed.abh2557

Diabetic neuropathic pain (DNP) is a common and devastating complication in patients with diabetes. The mechanisms mediating DNP are not completely elucidated, and effective treatments are lacking. A-fiber sensory neurons have been shown to mediate the development of mechanical allodynia in neuropat...