Binding of 16α-[ 18F]Fluoro-17β-estradiol to alphafetoprotein in Sprague-Dawley female rats affects blood levels
To examine the relationship between blood levels of 16α-[ 18F]fluoro-17β-estradiol( 18F-ES) and serum alphafetoprotein (AFP) concentration, we undertook a study in which serum from various aged (20–33 days old) Sprague-Dawley female rats injected with 18F-ES was analyzed for both blood activity leve...
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Published in | International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology Vol. 17; no. 8; pp. 769 - 773 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford
Elsevier Ltd
1990
Pergamon |
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Abstract | To examine the relationship between blood levels of 16α-[
18F]fluoro-17β-estradiol(
18F-ES) and serum alphafetoprotein (AFP) concentration, we undertook a study in which serum from various aged (20–33 days old) Sprague-Dawley female rats injected with
18F-ES was analyzed for both blood activity levels and AFP. There is a strong positive correlation between serum AFP concentration and
18F-ES blood levels (
r = 0.914,
P < 0.001), suggesting that the binding of
18F-ES by AFP has a significant effect on blood activity levels. The AFP concentration and ultimately the AFP-
18F-ES binding is dependent on the age and weight of the rat: younger, as well as low weight rats exhibited high AFP concentrations and consequently increased
18F-ES blood activity. The rats most suitable for comparative studying of labeled estrogens are 25–28 days of age and weigh a minimum of 50–55 g. Thus, the use of the immature rat model to compare labeled estrogens requires a careful consideration of possible interference from blood binding proteins (i.e. AFP), as well as potential receptor binding competition from endogenous estrogens produced during the estrous cycle. Comparable consideration of blood binding protens (sex steroid binding protein, SBP) and endogenous estrogens must be made in human studies, as well. |
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AbstractList | To examine the relationship between blood levels of 16α-[
18F]fluoro-17β-estradiol(
18F-ES) and serum alphafetoprotein (AFP) concentration, we undertook a study in which serum from various aged (20–33 days old) Sprague-Dawley female rats injected with
18F-ES was analyzed for both blood activity levels and AFP. There is a strong positive correlation between serum AFP concentration and
18F-ES blood levels (
r = 0.914,
P < 0.001), suggesting that the binding of
18F-ES by AFP has a significant effect on blood activity levels. The AFP concentration and ultimately the AFP-
18F-ES binding is dependent on the age and weight of the rat: younger, as well as low weight rats exhibited high AFP concentrations and consequently increased
18F-ES blood activity. The rats most suitable for comparative studying of labeled estrogens are 25–28 days of age and weigh a minimum of 50–55 g. Thus, the use of the immature rat model to compare labeled estrogens requires a careful consideration of possible interference from blood binding proteins (i.e. AFP), as well as potential receptor binding competition from endogenous estrogens produced during the estrous cycle. Comparable consideration of blood binding protens (sex steroid binding protein, SBP) and endogenous estrogens must be made in human studies, as well. To examine the relationship between blood levels of 16 alpha-[18F]fluoro-17 beta-estradiol(18F-ES) and serum alphafetoprotein (AFP) concentration, we undertook a study in which serum from various aged (20-33 days old) Sprague-Dawley female rats injected with 18F-ES was analyzed for both blood activity levels and AFP. There is a strong positive correlation between serum AFP concentration and 18F-ES blood levels (r = 0.914, P less than 0.001), suggesting that the binding of 18F-ES by AFP has a significant effect on blood activity levels. The AFP concentration and ultimately the AFP-18F-ES binding is dependent on the age and weight of the rat: younger, as well as low weight rats exhibited high AFP concentrations and consequently increased 18F-ES blood activity. The rats most suitable for comparative studying of labeled estrogens are 25-28 days of age and weigh a minimum of 50-55 g. Thus, the use of the immature rat model to compare labeled estrogens requires a careful consideration of possible interference from blood binding proteins (i.e. AFP), as well as potential receptor binding competition from endogenous estrogens produced during the estrous cycle. Comparable consideration of blood binding proteins (sex steroid binding protein, SBP) and endogenous estrogens must be made in human studies, as well. |
Author | Brodack, James W. Vanbrocklin, Henry F. Welch, Michael J. Katzenellenbogen, John A. Keenan, James F. Mathias, Carla J. Mizejewski, Gerald J. |
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Keywords | Radionuclide study Binding Enzyme Animal Serum Oestradiol 17β-dehydrogenase α-Fetoprotein Blood |
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Med. contributor: fullname: Kiesewetter – volume: 34 start-page: 2296 year: 1974 ident: 10.1016/0883-2897(90)90024-U_BIB2 article-title: Metabolism of rat α1-fetoprotein publication-title: Cancer Res. contributor: fullname: Colquhoun – volume: 34 start-page: 1510 year: 1974 ident: 10.1016/0883-2897(90)90024-U_BIB16 article-title: The use of radioimmunoassay for alpha-feto-protein in the diagnosis of malignancy publication-title: Cancer doi: 10.1002/1097-0142(197410)34:8+<1510::AID-CNCR2820340824>3.0.CO;2-Y contributor: fullname: Waldman |
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Snippet | To examine the relationship between blood levels of 16α-[
18F]fluoro-17β-estradiol(
18F-ES) and serum alphafetoprotein (AFP) concentration, we undertook a... To examine the relationship between blood levels of 16 alpha-[18F]fluoro-17 beta-estradiol(18F-ES) and serum alphafetoprotein (AFP) concentration, we undertook... |
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SubjectTerms | Aging - physiology alpha-Fetoproteins - metabolism Animals Biological and medical sciences Body Weight - physiology Estradiol - analogs & derivatives Estradiol - blood Estradiol - metabolism Female Investigative techniques, diagnostic techniques (general aspects) Medical sciences Miscellaneous. Technology Protein Binding Radionuclide investigations Rats Rats, Inbred Strains |
Title | Binding of 16α-[ 18F]Fluoro-17β-estradiol to alphafetoprotein in Sprague-Dawley female rats affects blood levels |
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