Maturation of human iPS cell-derived dopamine neuron precursors in alginate–Ca2+ hydrogel

• Published in: Biochimica et biophysica acta. General subjects Vol. 1850; no. 9; pp. 1669 - 1675
• Main Authors: Komatsu, Mitsue, Konagaya, Shuhei, Egawa, Edgar Y., Iwata, Hiroo
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.09.2015
• Subjects: Alginate; brain; cell aggregates; cell transplantation; cell viability; citrates; culture dishes; Dopamine; encapsulation; gels; humans; hydrocolloids; induced pluripotent stem cells; iPS cell; Microencapsulation; neurites; Neuron precursor; Parkinson disease; rats; tyrosine; Neuron precursor; Alginate; Microencapsulation; Dopamine; iPS cell

Pluripotent stem cells (embryonic stem/induced pluripotent stem cells) have been widely studied as a potential cell source for cell transplantation therapy of Parkinson's disease. However, some difficulties remain to be overcome. These include the need to prepare a large number of dopamine (DA)...