Aging-Associated Cognitive Decline is Reversed by D-Serine Supplementation

• Published in: eNeuro Vol. 9; no. 3; p. ENEURO.0176-22.2022
• Main Authors: Nava-Gómez, L., Calero-Vargas, I., Higinio-Rodríguez, F., Vázquez-Prieto, B., Olivares-Moreno, R., Ortiz-Retana, J., Aranda, P., Hernández-Chan, N., Rojas-Piloni, G., Alcauter, S., López-Hidalgo, M.
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 18.05.2022
• Subjects: New Research; Aging; fMRI; Cognitive Flexibility; D-serine; Functional brain connectivity

Brain aging is a natural process that involves structural and functional changes that lead to cognitive decline, even in healthy subjects. This detriment has been associated with NMDA receptor (NMDAR) hypofunction because of a reduction in the brain levels of D-serine, the endogenous NMDAR co-agonis...