Aging-Associated Cognitive Decline is Reversed by D-Serine Supplementation

Brain aging is a natural process that involves structural and functional changes that lead to cognitive decline, even in healthy subjects. This detriment has been associated with NMDA receptor (NMDAR) hypofunction because of a reduction in the brain levels of D-serine, the endogenous NMDAR co-agonis...

Full description

Saved in:
Bibliographic Details
Published ineNeuro Vol. 9; no. 3; p. ENEURO.0176-22.2022
Main Authors Nava-Gómez, L., Calero-Vargas, I., Higinio-Rodríguez, F., Vázquez-Prieto, B., Olivares-Moreno, R., Ortiz-Retana, J., Aranda, P., Hernández-Chan, N., Rojas-Piloni, G., Alcauter, S., López-Hidalgo, M.
Format Journal Article
LanguageEnglish
Published United States Society for Neuroscience 18.05.2022
Subjects
New Research
Aging
fMRI
Cognitive Flexibility
D-serine
Functional brain connectivity
Online AccessGet full text

Cover

Abstract Brain aging is a natural process that involves structural and functional changes that lead to cognitive decline, even in healthy subjects. This detriment has been associated with NMDA receptor (NMDAR) hypofunction because of a reduction in the brain levels of D-serine, the endogenous NMDAR co-agonist. However, it is not clear whether D-serine supplementation could be used as an intervention to reduce or reverse age-related brain alterations. In the present work, we aimed to analyze the D-serine effect on aging-associated alterations in cellular and large-scale brain systems that could support cognitive flexibility in rats. We found that D-serine supplementation reverts the age-related decline in cognitive flexibility, frontal dendritic spine density, and partially restored large-scale functional connectivity without inducing nephrotoxicity; instead, D-serine restored the thickness of the renal epithelial cells that were affected by age. Our results suggest that D-serine could be used as a therapeutic target to reverse age-related brain alterations.
AbstractList Brain aging is a natural process that involves structural and functional changes that lead to cognitive decline, even in healthy subjects. This detriment has been associated with NMDA receptor (NMDAR) hypofunction because of a reduction in the brain levels of D-serine, the endogenous NMDAR co-agonist. However, it is not clear whether D-serine supplementation could be used as an intervention to reduce or reverse age-related brain alterations. In the present work, we aimed to analyze the D-serine effect on aging-associated alterations in cellular and large-scale brain systems that could support cognitive flexibility in rats. We found that D-serine supplementation reverts the age-related decline in cognitive flexibility, frontal dendritic spine density, and partially restored large-scale functional connectivity without inducing nephrotoxicity; instead, D-serine restored the thickness of the renal epithelial cells that were affected by age. Our results suggest that D-serine could be used as a therapeutic target to reverse age-related brain alterations.
Brain aging is a natural process that involves structural and functional changes that lead to cognitive decline, even in healthy subjects. This detriment has been associated with N-methyl-D-aspartate receptor (NMDAR) hypofunction due to a reduction in the brain levels of D-serine, the endogenous NMDAR co-agonist. However, it is not clear if D-serine supplementation could be used as an intervention to reduce or reverse age-related brain alterations. In the present work, we aimed to analyze the D-serine effect on aging-associated alterations in cellular and large-scale brain systems that could support cognitive flexibility in rats. We found that D-serine supplementation reverts the age-related decline in cognitive flexibility, frontal dendritic spine density, and partially restored large-scale functional connectivity without inducing nephrotoxicity; instead, D-serine restored the thickness of the renal epithelial cells that were affected by age. Our results suggest that D-serine could be used as a therapeutic target to reverse age-related brain alterations. Age-related behavioral changes in cognitive performance occur as a physiological process of aging. Then, it is important to explore possible therapeutics to decrease, retard or reverse aging effects on the brain. NMDA receptor hypofunction contributes to the aging-associated cognitive decline. In the aged brain, there is a reduction in the brain levels of the NMDAR co-agonist, D-Serine. However, it is unclear if chronic D-serine supplementation could revert the age-detriment in brain functions. Our results show that D-serine supplementation reverts the age-associated decrease in cognitive flexibility, functional brain connectivity, and neuronal morphology. Our findings raise the possibility that restoring the brain levels of D-serine could be used as a therapeutic target to recover brain alterations associated with aging.
Brain aging is a natural process that involves structural and functional changes that lead to cognitive decline, even in healthy subjects. This detriment has been associated with N-methyl-D-aspartate receptor (NMDAR) hypofunction due to a reduction in the brain levels of D-serine, the endogenous NMDAR co-agonist. However, it is not clear if D-serine supplementation could be used as an intervention to reduce or reverse age-related brain alterations. In the present work, we aimed to analyze the D-serine effect on aging-associated alterations in cellular and large-scale brain systems that could support cognitive flexibility in rats. We found that D-serine supplementation reverts the age-related decline in cognitive flexibility, frontal dendritic spine density, and partially restored large-scale functional connectivity without inducing nephrotoxicity; instead, D-serine restored the thickness of the renal epithelial cells that were affected by age. Our results suggest that D-serine could be used as a therapeutic target to reverse age-related brain alterations.SIGNIFICANT STATEMENTAge-related behavioral changes in cognitive performance occur as a physiological process of aging. Then, it is important to explore possible therapeutics to decrease, retard or reverse aging effects on the brain. NMDA receptor hypofunction contributes to the aging-associated cognitive decline. In the aged brain, there is a reduction in the brain levels of the NMDAR co-agonist, D-Serine. However, it is unclear if chronic D-serine supplementation could revert the age-detriment in brain functions. Our results show that D-serine supplementation reverts the age-associated decrease in cognitive flexibility, functional brain connectivity, and neuronal morphology. Our findings raise the possibility that restoring the brain levels of D-serine could be used as a therapeutic target to recover brain alterations associated with aging.Brain aging is a natural process that involves structural and functional changes that lead to cognitive decline, even in healthy subjects. This detriment has been associated with N-methyl-D-aspartate receptor (NMDAR) hypofunction due to a reduction in the brain levels of D-serine, the endogenous NMDAR co-agonist. However, it is not clear if D-serine supplementation could be used as an intervention to reduce or reverse age-related brain alterations. In the present work, we aimed to analyze the D-serine effect on aging-associated alterations in cellular and large-scale brain systems that could support cognitive flexibility in rats. We found that D-serine supplementation reverts the age-related decline in cognitive flexibility, frontal dendritic spine density, and partially restored large-scale functional connectivity without inducing nephrotoxicity; instead, D-serine restored the thickness of the renal epithelial cells that were affected by age. Our results suggest that D-serine could be used as a therapeutic target to reverse age-related brain alterations.SIGNIFICANT STATEMENTAge-related behavioral changes in cognitive performance occur as a physiological process of aging. Then, it is important to explore possible therapeutics to decrease, retard or reverse aging effects on the brain. NMDA receptor hypofunction contributes to the aging-associated cognitive decline. In the aged brain, there is a reduction in the brain levels of the NMDAR co-agonist, D-Serine. However, it is unclear if chronic D-serine supplementation could revert the age-detriment in brain functions. Our results show that D-serine supplementation reverts the age-associated decrease in cognitive flexibility, functional brain connectivity, and neuronal morphology. Our findings raise the possibility that restoring the brain levels of D-serine could be used as a therapeutic target to recover brain alterations associated with aging.
Author Higinio-Rodríguez, F.
Rojas-Piloni, G.
Aranda, P.
Alcauter, S.
Vázquez-Prieto, B.
Hernández-Chan, N.
Calero-Vargas, I.
Ortiz-Retana, J.
Nava-Gómez, L.
López-Hidalgo, M.
Olivares-Moreno, R.
Author_xml – sequence: 1
  givenname: L.
  surname: Nava-Gómez
  fullname: Nava-Gómez, L.
– sequence: 2
  givenname: I.
  surname: Calero-Vargas
  fullname: Calero-Vargas, I.
– sequence: 3
  givenname: F.
  surname: Higinio-Rodríguez
  fullname: Higinio-Rodríguez, F.
– sequence: 4
  givenname: B.
  surname: Vázquez-Prieto
  fullname: Vázquez-Prieto, B.
– sequence: 5
  givenname: R.
  surname: Olivares-Moreno
  fullname: Olivares-Moreno, R.
– sequence: 6
  givenname: J.
  surname: Ortiz-Retana
  fullname: Ortiz-Retana, J.
– sequence: 7
  givenname: P.
  surname: Aranda
  fullname: Aranda, P.
– sequence: 8
  givenname: N.
  surname: Hernández-Chan
  fullname: Hernández-Chan, N.
– sequence: 9
  givenname: G.
  surname: Rojas-Piloni
  fullname: Rojas-Piloni, G.
– sequence: 10
  givenname: S.
  surname: Alcauter
  fullname: Alcauter, S.
– sequence: 11
  givenname: M.
  orcidid: 0000-0002-9801-9599
  surname: López-Hidalgo
  fullname: López-Hidalgo, M.
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35584913$$D View this record in MEDLINE/PubMed
BookMark eNp9UUtLAzEQDqL4_gWC7NHL1mSyyW4uQqn1hVioeg7Z7GyNbJO62Rb8926pinrwNMPM94DvOyDbPngk5ITRARPAz8cP4-fpZEBZLlOAAVCALbIPPOcpFADbP_Y9chzjK6WUSchZwXbJHheiyBTj--RuOHN-lg5jDNaZDqtkFGbedW6FySXaxnlMXEymuMI29t_yPblMH7Fd3x-Xi0WDc_Sd6VzwR2SnNk3E4895SJ6vxk-jm_R-cn07Gt6nlnPRpRKZEdxQZgBqkyuoKK2EKjLDK5FnZSazUllqkRbCYJUxW1aVzAshbV0wWfNDcrHRXSzLOVa2929Noxetm5v2XQfj9O-Pdy96FlZasUJmLOsFzj4F2vC2xNjpuYsWm8Z4DMuoQUqpqOIq76GnP72-Tb4C7AFqA7BtiLHFWlu3iaO3do1mVK_70pu-9LovDaDXffVc_of7Jf8f6wObJJlq
CitedBy_id crossref_primary_10_3390_biomedicines12122882
crossref_primary_10_3389_fnmol_2023_1174738
crossref_primary_10_3390_ph16060812
crossref_primary_10_1016_j_bbi_2024_11_022
crossref_primary_10_3390_ijms252212410
crossref_primary_10_3390_biomedicines12040853
crossref_primary_10_1038_s41398_024_02991_z
crossref_primary_10_3390_ijms232415542
crossref_primary_10_18632_aging_204652
crossref_primary_10_1007_s10522_024_10152_4
crossref_primary_10_3390_ijms26052104
crossref_primary_10_1038_s41570_023_00476_z
crossref_primary_10_1007_s00726_023_03338_6
Cites_doi 10.1093/ndt/gfw330
10.1016/j.bbapap.2020.140542
10.1038/nrn.2017.45
10.1016/j.neuint.2014.05.015
10.1016/j.neuropharm.2011.01.030
10.3389/fnagi.2021.755931
10.1097/00001756-200312020-00018
10.1016/j.tins.2016.09.007
10.1016/S1053-8119(03)00074-0
10.1162/089892903321593072
10.1007/BF00319848
10.1016/j.bbadis.2011.07.008
10.2174/1381612819666140110115603
10.1016/j.tins.2015.07.003
10.1002/ana.20977
10.1038/s41598-017-11947-x
10.1097/00001756-200409150-00001
10.1038/sj.npp.1300642
10.1016/j.biopsych.2021.10.012
10.1093/cercor/bhh032
10.3389/fphys.2021.687121
10.1089/brain.2015.0388
10.1037/0012-1649.41.4.661
10.1523/JNEUROSCI.0937-20.2020
10.1016/j.neuroscience.2019.01.066
10.3389/fnagi.2019.00234
10.1016/j.cger.2013.07.002
10.1667/RR15458.1
10.1073/pnas.1722677115
10.1016/j.neuroimage.2019.116278
10.1111/j.1474-9726.2012.00792.x
10.1016/j.neuroscience.2017.01.017
10.1016/j.neurobiolaging.2018.08.018
10.1523/JNEUROSCI.2828-08.2009
10.1111/j.1474-9726.2006.00216.x
10.1371/journal.pone.0067131
10.1111/j.1474-9726.2007.00283.x
10.1016/j.neuint.2012.03.008
10.1016/j.bbr.2017.08.010
10.1002/cne.21822
10.1002/hbm.10062
10.1016/j.jpba.2018.09.026
10.1016/j.neuropharm.2021.108720
10.3389/fpsyt.2021.754032
10.1523/JNEUROSCI.4825-12.2013
10.1074/jbc.C200074200
10.3389/fnagi.2010.00032
10.1073/pnas.95.26.15730
10.1016/j.jpba.2015.02.013
10.1073/pnas.1509262112
10.1006/bbrc.2002.6441
10.1371/journal.pone.0124859
10.1177/02698811211008560
10.1016/j.neulet.2011.08.059
10.1523/JNEUROSCI.0640-10.2010
10.1523/JNEUROSCI.0801-20.2020
10.1016/j.nicl.2018.05.037
10.1016/j.neurobiolaging.2013.02.012
10.3389/fnins.2013.00155
10.1038/nature08673
10.1016/S0047-6374(00)00104-4
10.1073/pnas.1410233111
10.1002/mrm.1910340409
10.1155/2018/5093048
10.1016/j.coph.2006.08.011
10.1016/j.neuropharm.2021.108614
10.1073/pnas.1200506109
10.1016/j.pnpbp.2018.12.003
10.1093/gerona/glac001
10.1016/j.neuroimage.2007.07.063
10.1016/bs.hespa.2016.06.002
10.1073/pnas.92.9.3948
10.1016/j.neurobiolaging.2009.09.001
10.1085/jgp.201411302
10.3389/fnbeh.2019.00008
10.1016/0047-6374(85)90111-3
10.3389/fneur.2017.00200
10.1016/j.cell.2006.02.051
10.1016/j.cell.2012.06.029
10.3389/fnins.2015.00473
10.3389/fnagi.2016.00190
10.1016/0304-3940(93)90476-2
10.1080/15622970701849986
10.1523/JNEUROSCI.0990-21.2021
10.1001/archgenpsychiatry.2010.78
10.3389/fnagi.2019.00312
10.1007/s11064-018-2634-4
10.15252/embj.201694085
10.1002/aja.1001270402
10.1098/rstb.2007.2097
10.1016/j.neurobiolaging.2020.09.010
10.1016/j.neuron.2007.10.038
10.1111/j.1471-4159.2006.03944.x
10.1007/s00018-010-0307-9
10.1016/j.neuroimage.2010.06.041
10.1016/j.neuroimage.2007.04.042
10.3109/10673229609017192
10.1016/j.neuro.2018.06.013
10.1016/j.neuroimage.2014.04.001
10.1016/j.neuroimage.2014.08.008
10.3389/fncel.2017.00166
10.1016/j.nbd.2011.10.006
10.1016/j.jneumeth.2011.10.020
10.1371/journal.pone.0156551
10.1523/JNEUROSCI.17-05-01604.1997
10.1016/j.neulet.2016.10.006
10.1073/pnas.0805423105
ContentType Journal Article
Copyright Copyright © 2022 Nava-Gómez et al.
Copyright © 2022 Nava-Gómez et al. 2022 Nava-Gómez et al.
Copyright_xml – notice: Copyright © 2022 Nava-Gómez et al.
– notice: Copyright © 2022 Nava-Gómez et al. 2022 Nava-Gómez et al.
DBID AAYXX
CITATION
NPM
7X8
5PM
DOI 10.1523/ENEURO.0176-22.2022
DatabaseName CrossRef
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
PubMed
MEDLINE - Academic
DatabaseTitleList CrossRef
PubMed
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 2373-2822
ExternalDocumentID PMC9186414
35584913
10_1523_ENEURO_0176_22_2022
Genre Journal Article
GrantInformation_xml – fundername: ;
  grantid: IN201121; IA208120; IA208022
– fundername: ;
  grantid: 472970; 815419); 786125; 778405; 778596; A1-S-8686; 2132; 171874
GroupedDBID 53G
5VS
AAYXX
ADBBV
ADRAZ
AKSEZ
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BCNDV
CITATION
GROUPED_DOAJ
H13
HYE
KQ8
M48
M~E
OK1
RHI
RPM
TFN
NPM
7X8
5PM
ID FETCH-LOGICAL-c335t-6e1a53a01a22fa792d00d5984a3d574b464b9c0ce085aed41cbdd67856cf816f3
IEDL.DBID M48
ISSN 2373-2822
IngestDate Thu Aug 21 18:13:42 EDT 2025
Thu Jul 10 18:05:49 EDT 2025
Thu Apr 03 07:00:53 EDT 2025
Tue Jul 01 02:36:08 EDT 2025
Thu Apr 24 23:06:18 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 3
Keywords Aging
fMRI
Cognitive Flexibility
D-serine
Functional brain connectivity
Language English
License https://creativecommons.org/licenses/by-nc-sa/4.0
Copyright © 2022 Nava-Gómez et al.
This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c335t-6e1a53a01a22fa792d00d5984a3d574b464b9c0ce085aed41cbdd67856cf816f3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
L.N.-G. and I.C.-V. contributed equally to this work.
Author contributions: M.L.-H. designed research; L.N.-G., I.C.-V., F.H.-R., B.V.-P., P.A., and N.H.-C. performed research; J.O.-R., G.R.-P., S.A., and M.L.-H. contributed unpublished reagents/analytic tools; L.N.-G., I.C.-V., F.H.-R., B.V.-P., R.O.-M., G.R.-P., S.A., and M.L.-H. analyzed data; L.N.-G., G.R.-P., S.A., and M.L.-H. wrote the paper.
The authors declare no competing financial interests.
This work was supported by grants from Consejo Nacional de Ciencia y Tecnologia (CONACyT) Ciencia de Frontera 171874 (to M.L.H.), CONACyT Problemas Nacionales 2132 (to N.H.C.), PAPIIT-DGAPA IA208120 (to M.L.H.), PAPIIT-DGAPA IA208022 (to M.L.H.), CONACYT Ciencia Básica A1-S-8686 (to G.R.-P.), and UNAM-DGAPA PAPIIT IN201121 (to G.R.-P.). L.N.-G. and P.A. are doctoral students from the Programa de Doctorado en Biomedicina, from Universidad Autónoma de Querétaro, and received CONACyT Fellowships 472970 and 815419. I.C.-V. is a doctoral student from the Programa de Doctorado en Ciencias Biomédicas, Universidad Nacional Autónoma de México (UNAM), and received the CONACyT Fellowship 786125. F.H.-R. and B.V.-P. are master students from the Programa de Maestría en Ciencias (Neurobiología) from UNAM and received CONACyT Fellowships 778405 and 778596.
ORCID 0000-0002-9801-9599
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.1523/ENEURO.0176-22.2022
PMID 35584913
PQID 2666909397
PQPubID 23479
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_9186414
proquest_miscellaneous_2666909397
pubmed_primary_35584913
crossref_citationtrail_10_1523_ENEURO_0176_22_2022
crossref_primary_10_1523_ENEURO_0176_22_2022
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2022-May-18
PublicationDateYYYYMMDD 2022-05-18
PublicationDate_xml – month: 05
  year: 2022
  text: 2022-May-18
  day: 18
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle eNeuro
PublicationTitleAlternate eNeuro
PublicationYear 2022
Publisher Society for Neuroscience
Publisher_xml – name: Society for Neuroscience
References 2023041302164585000_9.3.ENEURO.0176-22.2022.59
2023041302164585000_9.3.ENEURO.0176-22.2022.55
2023041302164585000_9.3.ENEURO.0176-22.2022.56
2023041302164585000_9.3.ENEURO.0176-22.2022.9
2023041302164585000_9.3.ENEURO.0176-22.2022.57
2023041302164585000_9.3.ENEURO.0176-22.2022.8
2023041302164585000_9.3.ENEURO.0176-22.2022.58
2023041302164585000_9.3.ENEURO.0176-22.2022.7
2023041302164585000_9.3.ENEURO.0176-22.2022.6
2023041302164585000_9.3.ENEURO.0176-22.2022.5
2023041302164585000_9.3.ENEURO.0176-22.2022.4
2023041302164585000_9.3.ENEURO.0176-22.2022.3
2023041302164585000_9.3.ENEURO.0176-22.2022.2
2023041302164585000_9.3.ENEURO.0176-22.2022.1
(2023041302164585000_9.3.ENEURO.0176-22.2022.49) 2014; 8
2023041302164585000_9.3.ENEURO.0176-22.2022.104
2023041302164585000_9.3.ENEURO.0176-22.2022.103
2023041302164585000_9.3.ENEURO.0176-22.2022.106
2023041302164585000_9.3.ENEURO.0176-22.2022.105
2023041302164585000_9.3.ENEURO.0176-22.2022.100
2023041302164585000_9.3.ENEURO.0176-22.2022.102
2023041302164585000_9.3.ENEURO.0176-22.2022.101
2023041302164585000_9.3.ENEURO.0176-22.2022.62
2023041302164585000_9.3.ENEURO.0176-22.2022.63
2023041302164585000_9.3.ENEURO.0176-22.2022.64
2023041302164585000_9.3.ENEURO.0176-22.2022.65
2023041302164585000_9.3.ENEURO.0176-22.2022.108
2023041302164585000_9.3.ENEURO.0176-22.2022.107
2023041302164585000_9.3.ENEURO.0176-22.2022.60
2023041302164585000_9.3.ENEURO.0176-22.2022.61
2023041302164585000_9.3.ENEURO.0176-22.2022.109
2023041302164585000_9.3.ENEURO.0176-22.2022.66
2023041302164585000_9.3.ENEURO.0176-22.2022.69
2023041302164585000_9.3.ENEURO.0176-22.2022.111
2023041302164585000_9.3.ENEURO.0176-22.2022.110
2023041302164585000_9.3.ENEURO.0176-22.2022.73
2023041302164585000_9.3.ENEURO.0176-22.2022.74
2023041302164585000_9.3.ENEURO.0176-22.2022.75
2023041302164585000_9.3.ENEURO.0176-22.2022.76
2023041302164585000_9.3.ENEURO.0176-22.2022.70
2023041302164585000_9.3.ENEURO.0176-22.2022.71
2023041302164585000_9.3.ENEURO.0176-22.2022.72
2023041302164585000_9.3.ENEURO.0176-22.2022.77
(2023041302164585000_9.3.ENEURO.0176-22.2022.99) 2011; 5
2023041302164585000_9.3.ENEURO.0176-22.2022.78
2023041302164585000_9.3.ENEURO.0176-22.2022.79
(2023041302164585000_9.3.ENEURO.0176-22.2022.67) 1985; 33
(2023041302164585000_9.3.ENEURO.0176-22.2022.36) 2017; 7
(2023041302164585000_9.3.ENEURO.0176-22.2022.84) 2021; 12
2023041302164585000_9.3.ENEURO.0176-22.2022.85
2023041302164585000_9.3.ENEURO.0176-22.2022.86
2023041302164585000_9.3.ENEURO.0176-22.2022.87
2023041302164585000_9.3.ENEURO.0176-22.2022.80
2023041302164585000_9.3.ENEURO.0176-22.2022.81
2023041302164585000_9.3.ENEURO.0176-22.2022.82
2023041302164585000_9.3.ENEURO.0176-22.2022.83
(2023041302164585000_9.3.ENEURO.0176-22.2022.19) 2021; 13
2023041302164585000_9.3.ENEURO.0176-22.2022.88
2023041302164585000_9.3.ENEURO.0176-22.2022.89
2023041302164585000_9.3.ENEURO.0176-22.2022.90
2023041302164585000_9.3.ENEURO.0176-22.2022.95
2023041302164585000_9.3.ENEURO.0176-22.2022.96
2023041302164585000_9.3.ENEURO.0176-22.2022.97
2023041302164585000_9.3.ENEURO.0176-22.2022.98
2023041302164585000_9.3.ENEURO.0176-22.2022.91
2023041302164585000_9.3.ENEURO.0176-22.2022.92
2023041302164585000_9.3.ENEURO.0176-22.2022.93
2023041302164585000_9.3.ENEURO.0176-22.2022.94
2023041302164585000_9.3.ENEURO.0176-22.2022.15
2023041302164585000_9.3.ENEURO.0176-22.2022.16
2023041302164585000_9.3.ENEURO.0176-22.2022.17
2023041302164585000_9.3.ENEURO.0176-22.2022.18
2023041302164585000_9.3.ENEURO.0176-22.2022.11
2023041302164585000_9.3.ENEURO.0176-22.2022.12
2023041302164585000_9.3.ENEURO.0176-22.2022.13
2023041302164585000_9.3.ENEURO.0176-22.2022.14
2023041302164585000_9.3.ENEURO.0176-22.2022.20
2023041302164585000_9.3.ENEURO.0176-22.2022.21
2023041302164585000_9.3.ENEURO.0176-22.2022.26
2023041302164585000_9.3.ENEURO.0176-22.2022.27
2023041302164585000_9.3.ENEURO.0176-22.2022.28
2023041302164585000_9.3.ENEURO.0176-22.2022.29
2023041302164585000_9.3.ENEURO.0176-22.2022.22
2023041302164585000_9.3.ENEURO.0176-22.2022.23
2023041302164585000_9.3.ENEURO.0176-22.2022.24
2023041302164585000_9.3.ENEURO.0176-22.2022.25
(2023041302164585000_9.3.ENEURO.0176-22.2022.68) 2019; 10
2023041302164585000_9.3.ENEURO.0176-22.2022.30
2023041302164585000_9.3.ENEURO.0176-22.2022.31
2023041302164585000_9.3.ENEURO.0176-22.2022.32
2023041302164585000_9.3.ENEURO.0176-22.2022.37
2023041302164585000_9.3.ENEURO.0176-22.2022.38
2023041302164585000_9.3.ENEURO.0176-22.2022.39
2023041302164585000_9.3.ENEURO.0176-22.2022.33
(2023041302164585000_9.3.ENEURO.0176-22.2022.10) 2015; 116
2023041302164585000_9.3.ENEURO.0176-22.2022.34
2023041302164585000_9.3.ENEURO.0176-22.2022.35
2023041302164585000_9.3.ENEURO.0176-22.2022.40
2023041302164585000_9.3.ENEURO.0176-22.2022.41
2023041302164585000_9.3.ENEURO.0176-22.2022.42
2023041302164585000_9.3.ENEURO.0176-22.2022.43
2023041302164585000_9.3.ENEURO.0176-22.2022.48
2023041302164585000_9.3.ENEURO.0176-22.2022.44
2023041302164585000_9.3.ENEURO.0176-22.2022.45
2023041302164585000_9.3.ENEURO.0176-22.2022.46
2023041302164585000_9.3.ENEURO.0176-22.2022.47
2023041302164585000_9.3.ENEURO.0176-22.2022.51
2023041302164585000_9.3.ENEURO.0176-22.2022.52
2023041302164585000_9.3.ENEURO.0176-22.2022.53
2023041302164585000_9.3.ENEURO.0176-22.2022.54
2023041302164585000_9.3.ENEURO.0176-22.2022.50
References_xml – ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.45
  doi: 10.1093/ndt/gfw330
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.79
  doi: 10.1016/j.bbapap.2020.140542
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.1
  doi: 10.1038/nrn.2017.45
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.4
  doi: 10.1016/j.neuint.2014.05.015
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.54
  doi: 10.1016/j.neuropharm.2011.01.030
– volume: 13
  start-page: 755931
  year: 2021
  ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.19
  article-title: Alternation in effective connectivity with cognitive aging: a longitudinal study of elderly populations
  publication-title: Front Aging Neurosci
  doi: 10.3389/fnagi.2021.755931
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.100
  doi: 10.1097/00001756-200312020-00018
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.105
  doi: 10.1016/j.tins.2016.09.007
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.90
  doi: 10.1016/S1053-8119(03)00074-0
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.87
  doi: 10.1162/089892903321593072
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.28
  doi: 10.1007/BF00319848
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.37
  doi: 10.1016/j.bbadis.2011.07.008
– volume: 10
  start-page: 163
  year: 2019
  ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.68
  article-title: Changes in resting-state functional connectivity of the hippocampus following cognitive effort predict memory decline at older age-a longitudinal fMRI study
  publication-title: Front Aging Neurosci
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.57
  doi: 10.2174/1381612819666140110115603
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.27
  doi: 10.1016/j.tins.2015.07.003
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.33
  doi: 10.1002/ana.20977
– volume: 7
  start-page: 11608
  year: 2017
  ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.36
  article-title: A NMDA-receptor calcium influx assay sensitive to stimulation by glutamate and glycine/D-serine
  publication-title: Sci Rep
  doi: 10.1038/s41598-017-11947-x
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.60
  doi: 10.1097/00001756-200409150-00001
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.86
  doi: 10.1038/sj.npp.1300642
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.50
  doi: 10.1016/j.biopsych.2021.10.012
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.89
  doi: 10.1093/cercor/bhh032
– volume: 12
  start-page: 687121
  year: 2021
  ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.84
  article-title: NMDA receptor hypofunction in the aging-associated malfunction of peripheral tissue
  publication-title: Front Physiol
  doi: 10.3389/fphys.2021.687121
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.102
  doi: 10.1089/brain.2015.0388
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.83
  doi: 10.1037/0012-1649.41.4.661
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.107
  doi: 10.1523/JNEUROSCI.0937-20.2020
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.61
  doi: 10.1016/j.neuroscience.2019.01.066
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.101
  doi: 10.3389/fnagi.2019.00234
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.38
  doi: 10.1016/j.cger.2013.07.002
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.15
  doi: 10.1667/RR15458.1
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.48
  doi: 10.1073/pnas.1722677115
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.35
  doi: 10.1016/j.neuroimage.2019.116278
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.42
  doi: 10.1111/j.1474-9726.2012.00792.x
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.46
  doi: 10.1016/j.neuroscience.2017.01.017
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.55
  doi: 10.1016/j.neurobiolaging.2018.08.018
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.44
  doi: 10.1523/JNEUROSCI.2828-08.2009
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.65
  doi: 10.1111/j.1474-9726.2006.00216.x
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.70
  doi: 10.1371/journal.pone.0067131
– volume: 5
  start-page: 26
  year: 2011
  ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.99
  article-title: An in vivo MRI template set for morphometry, tissue segmentation, and fMRI localization in rats
  publication-title: Front Neuroinformatics
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.31
  doi: 10.1111/j.1474-9726.2007.00283.x
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.75
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.78
  doi: 10.1016/j.neuint.2012.03.008
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.82
  doi: 10.1016/j.bbr.2017.08.010
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.63
  doi: 10.1002/cne.21822
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.93
  doi: 10.1002/hbm.10062
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.39
  doi: 10.1016/j.jpba.2018.09.026
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.62
  doi: 10.1016/j.neuropharm.2021.108720
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.69
  doi: 10.3389/fpsyt.2021.754032
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.64
  doi: 10.1523/JNEUROSCI.4825-12.2013
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.24
  doi: 10.1074/jbc.C200074200
– volume: 8
  start-page: 251
  year: 2014
  ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.49
  article-title: Distant functional connectivity for bimanual finger coordination declines with aging: an fMRI and SEM exploration
  publication-title: Front Hum Neurosci
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.81
  doi: 10.3389/fnagi.2010.00032
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.8
  doi: 10.1073/pnas.95.26.15730
– volume: 116
  start-page: 18
  year: 2015
  ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.10
  article-title: D-Serine in the aging hippocampus
  publication-title: J Pharm Biomed Anal
  doi: 10.1016/j.jpba.2015.02.013
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.30
  doi: 10.1073/pnas.1509262112
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.41
  doi: 10.1006/bbrc.2002.6441
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.16
  doi: 10.1371/journal.pone.0124859
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.95
  doi: 10.1177/02698811211008560
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.106
  doi: 10.1016/j.neulet.2011.08.059
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.14
  doi: 10.1523/JNEUROSCI.0640-10.2010
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.13
  doi: 10.1523/JNEUROSCI.0801-20.2020
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.66
  doi: 10.1016/j.nicl.2018.05.037
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.23
  doi: 10.1016/j.neurobiolaging.2013.02.012
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.94
  doi: 10.3389/fnins.2013.00155
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.43
  doi: 10.1038/nature08673
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.51
  doi: 10.1016/S0047-6374(00)00104-4
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.88
  doi: 10.1073/pnas.1410233111
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.11
  doi: 10.1002/mrm.1910340409
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.3
  doi: 10.1155/2018/5093048
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.72
  doi: 10.1016/j.coph.2006.08.011
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.6
  doi: 10.1016/j.neuropharm.2021.108614
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.58
  doi: 10.1073/pnas.1200506109
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.97
  doi: 10.1016/j.pnpbp.2018.12.003
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.18
  doi: 10.1093/gerona/glac001
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.109
  doi: 10.1016/j.neuroimage.2007.07.063
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.12
  doi: 10.1016/bs.hespa.2016.06.002
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.91
  doi: 10.1073/pnas.92.9.3948
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.98
  doi: 10.1016/j.neurobiolaging.2009.09.001
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.26
  doi: 10.1085/jgp.201411302
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.17
  doi: 10.3389/fnbeh.2019.00008
– volume: 33
  start-page: 95
  year: 1985
  ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.67
  article-title: Age-related change in brush borders of rat kidney cortex
  publication-title: Mech Ageing Dev
  doi: 10.1016/0047-6374(85)90111-3
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.34
  doi: 10.3389/fneur.2017.00200
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.71
  doi: 10.1016/j.cell.2006.02.051
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.73
  doi: 10.1016/j.cell.2012.06.029
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.52
  doi: 10.3389/fnins.2015.00473
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.9
  doi: 10.3389/fnagi.2016.00190
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.40
  doi: 10.1016/0304-3940(93)90476-2
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.104
  doi: 10.1080/15622970701849986
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.110
  doi: 10.1523/JNEUROSCI.0990-21.2021
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.96
  doi: 10.1001/archgenpsychiatry.2010.78
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.103
  doi: 10.3389/fnagi.2019.00312
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.53
  doi: 10.1007/s11064-018-2634-4
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.111
  doi: 10.15252/embj.201694085
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.77
  doi: 10.1002/aja.1001270402
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.85
  doi: 10.1098/rstb.2007.2097
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.59
  doi: 10.1016/j.neurobiolaging.2020.09.010
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.2
  doi: 10.1016/j.neuron.2007.10.038
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.47
  doi: 10.1111/j.1471-4159.2006.03944.x
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.80
  doi: 10.1007/s00018-010-0307-9
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.108
  doi: 10.1016/j.neuroimage.2010.06.041
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.7
  doi: 10.1016/j.neuroimage.2007.04.042
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.25
  doi: 10.3109/10673229609017192
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.20
  doi: 10.1016/j.neuro.2018.06.013
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.74
  doi: 10.1016/j.neuroimage.2014.04.001
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.21
  doi: 10.1016/j.neuroimage.2014.08.008
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.76
  doi: 10.3389/fncel.2017.00166
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.5
  doi: 10.1016/j.nbd.2011.10.006
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.29
  doi: 10.1016/j.jneumeth.2011.10.020
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.32
  doi: 10.1371/journal.pone.0156551
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.92
  doi: 10.1523/JNEUROSCI.17-05-01604.1997
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.22
  doi: 10.1016/j.neulet.2016.10.006
– ident: 2023041302164585000_9.3.ENEURO.0176-22.2022.56
  doi: 10.1073/pnas.0805423105
SSID ssj0001627181
Score 2.2848537
Snippet Brain aging is a natural process that involves structural and functional changes that lead to cognitive decline, even in healthy subjects. This detriment has...
SourceID pubmedcentral
proquest
pubmed
crossref
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage ENEURO.0176-22.2022
SubjectTerms New Research
Title Aging-Associated Cognitive Decline is Reversed by D-Serine Supplementation
URI https://www.ncbi.nlm.nih.gov/pubmed/35584913
https://www.proquest.com/docview/2666909397
https://pubmed.ncbi.nlm.nih.gov/PMC9186414
Volume 9
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9MwED9NQ5r2gvimDKYg8YhH_Jn4AaHSZV2mNUztOo2nyLEdDWnK2NZJ8N9zTtKKAuM1_lByd777ne38DuCdS13l0BRI5Z0hgnpPjI5TohJqhbRVnZiwDzkp1OFcHJ3L8w1YVkXtBXj7z9Qu1JOa31zu_bj--QkX_Meueg__kBXh1tse2pYiLPxcxdAnP8DQlISSBpMe77ebLoqhL6Y9-9A9Y7dhK3COC035erD6C4H-eZHyt8h08Age9pAyGnY28Bg2fPMEtib9oflTOBqO82JMWgLHfIieKhp9GRf5aX6WRfvZ6DgvsiifRdPsLJvOsPXz12gf3ew0PJ_NT06OW8L_di_rGcwPstPRIelLKBDLuVwQ5amR3MTUMFabRDMXx07qVBjuZCIqoUSlbWw9Ii_jnaC2cg7jl1S2Tqmq-XPYbK4a_xIi7ZWNU_xUaWuRqNp4Y1gtuabWp9zVA2BLWZW25xcPZS4uy5BnoKzLTtZlkHXJWBlkPYD3q0HfO3qN_3d_u1RCicsgnG2Yxl_d3ZaIMzDP14iuBvCiU8pqwqU2B5CsqWvVIVBsr7c03y5aqm1NUyWoeHXvnDuwHV4s3Ceg6WvYXNzc-TcIUxbVbpve77YG-As_BN4p
linkProvider Scholars Portal
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=AGING-ASSOCIATED+COGNITIVE+DECLINE+IS+REVERSED+BY+D-SERINE+SUPPLEMENTATION&rft.jtitle=eNeuro&rft.au=Nava-G%C3%B3mez%2C+L&rft.au=Calero-Vargas%2C+I&rft.au=Higinio-Rodr%C3%ADguez%2C+F&rft.au=V%C3%A1zquez-Prieto%2C+B&rft.date=2022-05-18&rft.eissn=2373-2822&rft_id=info:doi/10.1523%2FENEURO.0176-22.2022&rft_id=info%3Apmid%2F35584913&rft.externalDocID=35584913
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2373-2822&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2373-2822&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2373-2822&client=summon