Novel berberine derivatives as adjuvants in the battle against Acinetobacter baumannii: A promising strategy for combating multi-drug resistance

• Published in: Chinese chemical letters Vol. 35; no. 10; pp. 109506 - 340
• Main Authors: Zhao, Liping, Guo, Xixi, Zhang, Zhimeng, Lu, Xi, Zeng, Qingxuan, Fan, Tianyun, Zhang, Xintong, Chen, Fenbei, Xu, Mengyi, Yuan, Min, Li, Zhenjun, Jiang, Jiandong, Pang, Jing, You, Xuefu, Wang, Yanxiang, Song, Danqing
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.10.2024; Beijing Key Laboratory of Antimicrobial Agents,Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China%State Key Laboratory for Infectious Diseases Prevention and Control,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease,National Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China
• Subjects: Acinetobacter baumannii; Berberine derivatives; Efflux; Iron acquisition; Rational design; Synergistic effect; Efflux; Acinetobacter baumannii; Rational design; Synergistic effect; Berberine derivatives; Iron acquisition

The development of resistance against most of the available antibiotics has made Acinetobacter baumannii (A. baumannii) a pathogen of high risk. In this study, thirty novel berberine derivatives are rationally designed, synthesized, and evaluated for their synergistic antibacterial activities agains...