OLED catheters for inner-body phototherapy: A case of type 2 diabetes mellitus improved via duodenal photobiomodulation

Phototherapeutics has shown promise in treating various diseases without surgical or drug interventions. However, it is challenging to use it in inner-body applications due to the limited light penetration depth through the skin. Therefore, we propose an organic light-emitting diode (OLED) catheter...

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Published inScience advances Vol. 9; no. 35; p. eadh8619
Main Authors Sim, Jee Hoon, Kwon, Jinhee, Chae, Hyeonwook, Kim, Su-Bon, Cho, Hyunsu, Lee, Woochan, Kim, So Hee, Byun, Chun-Won, Hahn, Sangin, Park, Do Hyun, Yoo, Seunghyup
Format Journal Article
LanguageEnglish
Published United States 01.09.2023
Subjects
Animals
Catheters
Diabetes Mellitus, Type 2 - therapy
Duodenum
Hyperglycemia - therapy
Phototherapy
Rats
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Abstract Phototherapeutics has shown promise in treating various diseases without surgical or drug interventions. However, it is challenging to use it in inner-body applications due to the limited light penetration depth through the skin. Therefore, we propose an organic light-emitting diode (OLED) catheter as an effective photobiomodulation (PBM) platform useful for tubular organs such as duodenums. A fully encapsulated highly flexible OLED is mounted over a round columnar structure, producing axially uniform illumination without local hotspots. The biocompatible and airtight OLED catheter can operate in aqueous environments for extended periods, meeting the essential requirements for inner-body medical applications. In a diabetic Goto-Kakizaki (GK) rat model, the red OLED catheter delivering 798 mJ of energy is shown to reduce hyperglycemia and insulin resistance compared to the sham group. Results are further supported by the subdued liver fibrosis, illustrating the immense potential of the OLED-catheter-based internal PBM for the treatment of type 2 diabetes and other diseases yet to be identified.
AbstractList Phototherapeutics has shown promise in treating various diseases without surgical or drug interventions. However, it is challenging to use it in inner-body applications due to the limited light penetration depth through the skin. Therefore, we propose an organic light-emitting diode (OLED) catheter as an effective photobiomodulation (PBM) platform useful for tubular organs such as duodenums. A fully encapsulated highly flexible OLED is mounted over a round columnar structure, producing axially uniform illumination without local hotspots. The biocompatible and airtight OLED catheter can operate in aqueous environments for extended periods, meeting the essential requirements for inner-body medical applications. In a diabetic Goto-Kakizaki (GK) rat model, the red OLED catheter delivering 798 mJ of energy is shown to reduce hyperglycemia and insulin resistance compared to the sham group. Results are further supported by the subdued liver fibrosis, illustrating the immense potential of the OLED-catheter-based internal PBM for the treatment of type 2 diabetes and other diseases yet to be identified.
Phototherapeutics has shown promise in treating various diseases without surgical or drug interventions. However, it is challenging to use it in inner-body applications due to the limited light penetration depth through the skin. Therefore, we propose an organic light-emitting diode (OLED) catheter as an effective photobiomodulation (PBM) platform useful for tubular organs such as duodenums. A fully encapsulated highly flexible OLED is mounted over a round columnar structure, producing axially uniform illumination without local hotspots. The biocompatible and airtight OLED catheter can operate in aqueous environments for extended periods, meeting the essential requirements for inner-body medical applications. In a diabetic Goto-Kakizaki (GK) rat model, the red OLED catheter delivering 798 mJ of energy is shown to reduce hyperglycemia and insulin resistance compared to the sham group. Results are further supported by the subdued liver fibrosis, illustrating the immense potential of the OLED-catheter–based internal PBM for the treatment of type 2 diabetes and other diseases yet to be identified. OLED catheter treats type 2 diabetes mellitus in Goto-Kakizaki rats through targeted internal photobiomodulation.
Author Yoo, Seunghyup
Lee, Woochan
Sim, Jee Hoon
Park, Do Hyun
Chae, Hyeonwook
Kim, So Hee
Byun, Chun-Won
Hahn, Sangin
Cho, Hyunsu
Kwon, Jinhee
Kim, Su-Bon
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Cites_doi 10.1002/adom.202100269
10.1109/JSTQE.2004.824072
10.1063/1.3115144
10.3389/fcimb.2015.00084
10.1002/jbio.201960140
10.1126/sciadv.aas9530
10.1111/j.1365-2133.2009.09096.x
10.4103/2230-8210.146874
10.1002/advs.202204622
10.1038/s41598-022-13080-w
10.1016/j.orgel.2011.10.024
10.1007/s10928-010-9182-0
10.1143/JJAP.51.09MH01
10.1038/s41598-022-15197-4
10.1016/S0140-6736(17)30058-2
10.1002/adma.202005630
10.1038/s41598-017-19096-x
10.1124/jpet.111.185686
10.1002/admi.202100856
10.1038/srep35446
10.1038/s41377-019-0221-3
10.1210/jc.2006-0587
10.3109/10550490903205579
10.1016/S0002-9440(10)65596-4
10.1002/adma.201907539
10.1128/msphere.00851-21
10.1677/JOE-09-0260
10.1016/j.gie.2019.03.024
10.1002/adma.200390051
10.1002/admt.201700391
10.1016/j.jphotobiol.2015.04.018
10.1194/jlr.M300368-JLR200
10.1073/pnas.2007395117
10.1021/acsami.1c12253
10.3389/fmed.2020.00467
10.1146/annurev.clinpsy.4.022007.141207
10.1016/j.orgel.2012.02.008
10.1371/journal.pone.0115175
10.1016/j.physbeh.2005.08.052
10.1016/S0149-7634(97)00051-1
10.1111/php.13550
10.3389/fnut.2022.886902
10.1038/s41467-020-20016-3
10.1002/sdtp.10495
10.1053/j.gastro.2018.02.010
10.1089/photob.2019.4628
10.1016/j.orgel.2021.106419
10.1063/1.2172734
10.1016/j.orgel.2020.105704
10.3390/nano10030558
10.3390/cells11213490
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References e_1_3_2_26_2
e_1_3_2_49_2
e_1_3_2_28_2
e_1_3_2_41_2
e_1_3_2_20_2
e_1_3_2_43_2
e_1_3_2_22_2
e_1_3_2_45_2
e_1_3_2_24_2
e_1_3_2_47_2
e_1_3_2_9_2
e_1_3_2_16_2
e_1_3_2_37_2
e_1_3_2_7_2
e_1_3_2_18_2
e_1_3_2_39_2
e_1_3_2_54_2
e_1_3_2_10_2
e_1_3_2_31_2
e_1_3_2_52_2
e_1_3_2_5_2
e_1_3_2_12_2
e_1_3_2_33_2
e_1_3_2_3_2
e_1_3_2_14_2
e_1_3_2_35_2
e_1_3_2_50_2
e_1_3_2_27_2
e_1_3_2_48_2
e_1_3_2_29_2
e_1_3_2_40_2
e_1_3_2_21_2
e_1_3_2_42_2
e_1_3_2_23_2
e_1_3_2_44_2
e_1_3_2_25_2
e_1_3_2_46_2
e_1_3_2_15_2
e_1_3_2_38_2
e_1_3_2_8_2
e_1_3_2_17_2
e_1_3_2_6_2
e_1_3_2_19_2
Beddow S. A. (e_1_3_2_53_2) 2012; 5
e_1_3_2_30_2
e_1_3_2_32_2
e_1_3_2_51_2
e_1_3_2_11_2
e_1_3_2_34_2
e_1_3_2_4_2
e_1_3_2_13_2
e_1_3_2_36_2
e_1_3_2_55_2
e_1_3_2_2_2
References_xml – ident: e_1_3_2_4_2
  doi: 10.1002/adom.202100269
– ident: e_1_3_2_26_2
  doi: 10.1109/JSTQE.2004.824072
– volume: 5
  start-page: 681
  year: 2012
  ident: e_1_3_2_53_2
  article-title: Fasting hyperglycemia in the Goto-Kakizaki rat is dependent on corticosterone: A confounding variable in rodent models of type 2 diabetes
  publication-title: Dis. Model. Mech.
  contributor:
    fullname: Beddow S. A.
– ident: e_1_3_2_27_2
  doi: 10.1063/1.3115144
– ident: e_1_3_2_41_2
  doi: 10.3389/fcimb.2015.00084
– ident: e_1_3_2_17_2
  doi: 10.1002/jbio.201960140
– ident: e_1_3_2_49_2
  doi: 10.1126/sciadv.aas9530
– ident: e_1_3_2_6_2
  doi: 10.1111/j.1365-2133.2009.09096.x
– ident: e_1_3_2_38_2
  doi: 10.4103/2230-8210.146874
– ident: e_1_3_2_7_2
  doi: 10.1002/advs.202204622
– ident: e_1_3_2_24_2
  doi: 10.1038/s41598-022-13080-w
– ident: e_1_3_2_30_2
  doi: 10.1016/j.orgel.2011.10.024
– ident: e_1_3_2_37_2
  doi: 10.1007/s10928-010-9182-0
– ident: e_1_3_2_50_2
  doi: 10.1143/JJAP.51.09MH01
– ident: e_1_3_2_11_2
  doi: 10.1038/s41598-022-15197-4
– ident: e_1_3_2_13_2
  doi: 10.1016/S0140-6736(17)30058-2
– ident: e_1_3_2_14_2
– ident: e_1_3_2_2_2
  doi: 10.1002/adma.202005630
– ident: e_1_3_2_18_2
  doi: 10.1038/s41598-017-19096-x
– ident: e_1_3_2_36_2
  doi: 10.1124/jpet.111.185686
– ident: e_1_3_2_10_2
  doi: 10.1002/admi.202100856
– ident: e_1_3_2_29_2
  doi: 10.1038/srep35446
– ident: e_1_3_2_9_2
  doi: 10.1038/s41377-019-0221-3
– ident: e_1_3_2_42_2
  doi: 10.1210/jc.2006-0587
– ident: e_1_3_2_20_2
  doi: 10.3109/10550490903205579
– ident: e_1_3_2_54_2
  doi: 10.1016/S0002-9440(10)65596-4
– ident: e_1_3_2_3_2
  doi: 10.1002/adma.201907539
– ident: e_1_3_2_39_2
  doi: 10.1128/msphere.00851-21
– ident: e_1_3_2_12_2
  doi: 10.1677/JOE-09-0260
– ident: e_1_3_2_16_2
  doi: 10.1016/j.gie.2019.03.024
– ident: e_1_3_2_23_2
  doi: 10.1002/adma.200390051
– ident: e_1_3_2_5_2
  doi: 10.1002/admt.201700391
– ident: e_1_3_2_19_2
  doi: 10.1016/j.jphotobiol.2015.04.018
– ident: e_1_3_2_43_2
  doi: 10.1194/jlr.M300368-JLR200
– ident: e_1_3_2_8_2
  doi: 10.1073/pnas.2007395117
– ident: e_1_3_2_28_2
  doi: 10.1021/acsami.1c12253
– ident: e_1_3_2_44_2
  doi: 10.3389/fmed.2020.00467
– ident: e_1_3_2_46_2
– ident: e_1_3_2_22_2
  doi: 10.1146/annurev.clinpsy.4.022007.141207
– ident: e_1_3_2_51_2
  doi: 10.1016/j.orgel.2012.02.008
– ident: e_1_3_2_40_2
  doi: 10.1371/journal.pone.0115175
– ident: e_1_3_2_21_2
  doi: 10.1016/j.physbeh.2005.08.052
– ident: e_1_3_2_34_2
  doi: 10.1016/S0149-7634(97)00051-1
– ident: e_1_3_2_45_2
  doi: 10.1111/php.13550
– ident: e_1_3_2_47_2
  doi: 10.3389/fnut.2022.886902
– ident: e_1_3_2_25_2
  doi: 10.1038/s41467-020-20016-3
– ident: e_1_3_2_55_2
  doi: 10.1002/sdtp.10495
– ident: e_1_3_2_15_2
  doi: 10.1053/j.gastro.2018.02.010
– ident: e_1_3_2_48_2
  doi: 10.1089/photob.2019.4628
– ident: e_1_3_2_52_2
  doi: 10.1016/j.orgel.2021.106419
– ident: e_1_3_2_31_2
  doi: 10.1063/1.2172734
– ident: e_1_3_2_32_2
  doi: 10.1016/j.orgel.2020.105704
– ident: e_1_3_2_33_2
  doi: 10.3390/nano10030558
– ident: e_1_3_2_35_2
  doi: 10.3390/cells11213490
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Snippet Phototherapeutics has shown promise in treating various diseases without surgical or drug interventions. However, it is challenging to use it in inner-body...
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SubjectTerms Animals
Catheters
Diabetes Mellitus, Type 2 - therapy
Duodenum
Hyperglycemia - therapy
Phototherapy
Rats
Title OLED catheters for inner-body phototherapy: A case of type 2 diabetes mellitus improved via duodenal photobiomodulation
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