Modelling human embryogenesis: embryo-like structures spark ethical and policy debate

• Published in: Human reproduction update Vol. 26; no. 6; pp. 779 - 798
• Main Authors: Pereira Daoud, Ana M, Popovic, Mina, Dondorp, Wybo J, Trani Bustos, Marc, Bredenoord, Annelien L, Chuva de Sousa Lopes, Susana M, van den Brink, Susanne C, Roelen, Bernard A J, de Wert, Guido M W R, Heindryckx, Björn
• Format: Journal Article
• Language: English
• Published: England 01.11.2020
• Subjects: blastoids; stem cells; embryoids; embryogenesis; embryonic stem cells; gastruloids; pluripotency; ethics; embryo-like structures; trophoblast stem cells

Studying the human peri-implantation period remains hindered by the limited accessibility of the in vivo environment and scarcity of research material. As such, continuing efforts have been directed towards developing embryo-like structures (ELS) from pluripotent stem cells (PSCs) that recapitulate...