Practical and scalable synthesis of beclomethasone dipropionate

• Published in: Steroids Vol. 177; pp. 108948 - 108953
• Main Authors: Welideniya, Dhanushi T., Jayathilaka, Adeesha S., Acharige, Anjana Delpe, Samanthi, K.A.U., Wanninayake, Umayangani K., Perera, Shashika S., Rajapaksha, Weranga, Fernando, Chamod C., Hewadikaram, Madhavi, Buddhika, Janani, Gunasekara, Pivini, Karunaratne, Veranja, Amaratunga, G.A.J., Gunasekera, Dinara S.
• Format: Journal Article
• Language: English
• Published: NEW YORK Elsevier Inc 01.01.2022; Elsevier
• Subjects: Beclomethasone; Beclomethasone - chemical synthesis; Beclomethasone - chemistry; Beclomethasone dipropionate; Biochemistry & Molecular Biology; DB-11; Endocrinology & Metabolism; Glucocorticoids; Life Sciences & Biomedicine; Molecular Conformation; Propionic anhydride; Science & Technology; Stereoisomerism; Triethyl orthopropionate; Beclomethasone dipropionate; Triethyl orthopropionate; Beclomethasone; Propionic anhydride; DB-11; Glucocorticoids; THERAPEUTIC INDEX; INHALED CORTICOSTEROIDS; CHILDREN

[Display omitted] •Practical and scalable approach to synthesize beclomethasone dipropionate.•Readily available and cost-effective intermediate DB-11 as the starting material.•Optimized consistent conversion of DB-11 to beclomethasone with high purity.•A one-pot conversion of beclomethasone to beclo...