An Unusual Case of Low Vancomycin Exposure Despite Extremely High Vancomycin Doses Accompanied by Renal Toxicity: A Grand Round
This grand round describes the case of a patient who received 10 grams (143.5 mg/kg) of vancomycin every 24 hours via continuous infusion, in whom the highest observed level was only 15.4 mg/L. Despite subtherapeutic levels, renal impairment was encountered, which resolved after the discontinuation...
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| Published in | Therapeutic drug monitoring Vol. 45; no. 2; p. 136 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
01.04.2023
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| Subjects | |
| Online Access | Get more information |
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| Abstract | This grand round describes the case of a patient who received 10 grams (143.5 mg/kg) of vancomycin every 24 hours via continuous infusion, in whom the highest observed level was only 15.4 mg/L. Despite subtherapeutic levels, renal impairment was encountered, which resolved after the discontinuation of vancomycin. Glomerular hyperfiltration was found through nuclear glomerular filtration rate measurement, which likely explains the need for high doses (>6 grams per 24 hours continuous infusion) without reaching therapeutic serum levels. |
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| AbstractList | This grand round describes the case of a patient who received 10 grams (143.5 mg/kg) of vancomycin every 24 hours via continuous infusion, in whom the highest observed level was only 15.4 mg/L. Despite subtherapeutic levels, renal impairment was encountered, which resolved after the discontinuation of vancomycin. Glomerular hyperfiltration was found through nuclear glomerular filtration rate measurement, which likely explains the need for high doses (>6 grams per 24 hours continuous infusion) without reaching therapeutic serum levels. |
| Author | van Diemen, Jeske J K van Schip, Anne M Harris, Vanessa C van Hest, Reinier M |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36728568$$D View this record in MEDLINE/PubMed |
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| Snippet | This grand round describes the case of a patient who received 10 grams (143.5 mg/kg) of vancomycin every 24 hours via continuous infusion, in whom the highest... |
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| SubjectTerms | Anti-Bacterial Agents Humans Kidney Kidney Diseases - chemically induced Kidney Diseases - drug therapy Teaching Rounds Vancomycin |
| Title | An Unusual Case of Low Vancomycin Exposure Despite Extremely High Vancomycin Doses Accompanied by Renal Toxicity: A Grand Round |
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