Intraoperative confocal laser endomicroscopy: prospective in vivo feasibility study of a clinical-grade system for brain tumors

• Published in: Journal of neurosurgery Vol. 138; no. 3; p. 587
• Main Authors: Abramov, Irakliy, Park, Marian T, Belykh, Evgenii, Dru, Alexander B, Xu, Yuan, Gooldy, Timothy C, Scherschinski, Lea, Farber, S Harrison, Little, Andrew S, Porter, Randall W, Smith, Kris A, Lawton, Michael T, Eschbacher, Jennifer M, Preul, Mark C
• Format: Journal Article
• Language: English
• Published: United States 01.03.2023
• Subjects: Brain Neoplasms - surgery; Feasibility Studies; Humans; Lasers; Microscopy, Confocal - methods; Prospective Studies; fluorescence-guided surgery; telemedicine; intraoperative diagnosis; confocal laser endomicroscopy; neurosurgery; neuropathology; oncology

The authors evaluated the feasibility of using the first clinical-grade confocal laser endomicroscopy (CLE) system using fluorescein sodium for intraoperative in vivo imaging of brain tumors. A CLE system cleared by the FDA was used in 30 prospectively enrolled patients with 31 brain tumors (13 glio...