History of the development of new vitamin D analogs: studies on 22-oxacalcitriol (OCT) and 2β-(3-hydroxypropoxy)calcitriol (ED-71)

• Published in: Steroids Vol. 66; no. 3; pp. 137 - 146
• Main Authors: Nishii, Y., Okano, T.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.03.2001; Elsevier Science
• Subjects: 1α,25(OH) 2D 3; Biological and medical sciences; ED-71; General and cellular metabolism. Vitamins; KH-1060; MC-903; Medical sciences; OCT; Osteoporosis; Pharmacology. Drug treatments; Psoriasis; VDR; Vitamin D analogs; OCT; Osteoporosis; ED-71; Psoriasis; VDR; 1α,25(OH) 2D 3; KH-1060; Vitamin D analogs; MC-903; Vitamin D; Steroid hormone; Analog; Leukemia; Diseases of the osteoarticular system; Calcitriol; Malignant hemopathy; Bone disease; Review; Case history

In 1981 Suda and his colleagues first reported the new activity of calcitriol namely its ability to differentiate the myeloid leukemia cells into normal monocytes-macrophages. However, the possibility of using calcitriol as an antileukemic drug was not feasible because of its potent calcemic effects...