Establishment of a leucine-based poly(ester amide)s library with self-anticancer effect as nano-drug carrier for colorectal cancer treatment

• Published in: Chinese chemical letters Vol. 35; no. 12; pp. 109689 - 185
• Main Authors: Tong, Tong, Chen, Lezong, Wu, Siying, Cao, Zhong, Song, Yuanbin, Wu, Jun
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.12.2024; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510120,China; School of Biomedical Engineering,Sun Yat-sen University,Shenzhen 518057,China%Department of Hematologic Oncology,State Key Laboratory of Oncology in South China,Guangdong Provincial Clinical Research Center for Cancer,Sun Yat-sen University Cancer Center,Guangzhou 510060,China%Bioscience and Biomedical Engineering Thrust,The Hong Kong University of Science and Technology (Guangzhou),Nansha,Guangzhou 511400,China%Bioscience and Biomedical Engineering Thrust,The Hong Kong University of Science and Technology (Guangzhou),Nansha,Guangzhou 511400,China; Division of Life Science,The Hong Kong University of Science and Technology,Hong Kong SAR 999077,China
• Subjects: Colorectal cancer; Drug delivery; Leucine-based poly(ester amide)s; Nanoplatform; Structure-property; Drug delivery; Structure-property; Leucine-based poly(ester amide)s; Nanoplatform; Colorectal cancer

Colorectal cancer is a common cancer worldwide. Traditional chemotherapeutic drugs often face limitations such as poor aqueous solubility and high systemic toxicity, which can lead to adverse side effects and limited therapeutic efficacy. In this study, a library of one kind of biodegradable and bio...