Methylsulfonic Acid Adsorbed on Silica Gel as a Solid Acid for Dimerization of Indoles: A Convenient Synthesis of 2,3′-Bi(3H-indol)-3-one Oximes
A simple, convenient, and efficient approach for the synthesis of (E)-2,3′-bi(3H-indol)-3-one oxime derivatives has been developed. The methodology is based on a three-component coupling reaction of indoles and sodium nitrite using a silica-supported methylsulfonic acid as solid acid. The practical...
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Published in | Synthetic communications Vol. 43; no. 21; pp. 2926 - 2935 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
PHILADELPHIA
Taylor & Francis Group
02.11.2013
Taylor & Francis Taylor & Francis Ltd |
Subjects | |
Online Access | Get full text |
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Summary: | A simple, convenient, and efficient approach for the synthesis of (E)-2,3′-bi(3H-indol)-3-one oxime derivatives has been developed. The methodology is based on a three-component coupling reaction of indoles and sodium nitrite using a silica-supported methylsulfonic acid as solid acid. The practical utility of this three-component coupling reaction has been demonstrated in the gram-scale dimerization of indole.
[Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource: Full experimental and spectral details.] |
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ISSN: | 0039-7911 1532-2432 |
DOI: | 10.1080/00397911.2012.751611 |