Assessment and Management of Declining Physical Function in Aging Dogs

Aging is the leading cause of disability, disease, and death in adult dogs. One major consequence of aging is diminishing physical function. For normal functioning, basic elements such as strength, balance, and energy must be present. These must then be integrated to enable higher levels of function...

Full description

Saved in:
Bibliographic Details
Published inTopics in companion animal medicine Vol. 51; p. 100732
Main Authors McKenzie, Brennen A., Chen, Frances L.
Format Journal Article
LanguageEnglish
Published Philadelphia Elsevier Inc 01.11.2022
Elsevier Limited
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Aging is the leading cause of disability, disease, and death in adult dogs. One major consequence of aging is diminishing physical function. For normal functioning, basic elements such as strength, balance, and energy must be present. These must then be integrated to enable higher levels of function, from simple walking and feeding to the complex demands of social roles, such as family companion or working search-and-rescue dog. Biological aging processes, such as loss of muscle strength, diminished cardiorespiratory function, chronic inflammation, and age-associated diseases, as well as the adverse effects of medical treatments, all contribute to physical dysfunction. Contextual elements, such as lack of opportunity for physical exercise or restricted access to veterinary care due to owner socioeconomic circumstances, also influence age-associated functional decline in dogs. In humans, well-established clinical assessments are available to evaluate physical function, and these can predict disability, morbidity, and mortality. There are also well-supported interventions that preserve and restore function and reduce the risk of death and disease in the elderly. Because the fundamental biology and the clinical phenotype of aging are very similar in humans and dogs, these assessments and interventions can likely be adapted for use in mitigating declining physical function in geriatric canines. This review evaluates the decline in physical function with age in dogs and the potential utility in this species of clinical assessment tools and interventions developed for humans. [Display omitted]
AbstractList Aging is the leading cause of disability, disease, and death in adult dogs. One major consequence of aging is diminishing physical function. For normal functioning, basic elements such as strength, balance, and energy must be present. These must then be integrated to enable higher levels of function, from simple walking and feeding to the complex demands of social roles, such as family companion or working search-and-rescue dog. Biological aging processes, such as loss of muscle strength, diminished cardiorespiratory function, chronic inflammation, and age-associated diseases, as well as the adverse effects of medical treatments, all contribute to physical dysfunction. Contextual elements, such as lack of opportunity for physical exercise or restricted access to veterinary care due to owner socioeconomic circumstances, also influence age-associated functional decline in dogs. In humans, well-established clinical assessments are available to evaluate physical function, and these can predict disability, morbidity, and mortality. There are also well-supported interventions that preserve and restore function and reduce the risk of death and disease in the elderly. Because the fundamental biology and the clinical phenotype of aging are very similar in humans and dogs, these assessments and interventions can likely be adapted for use in mitigating declining physical function in geriatric canines. This review evaluates the decline in physical function with age in dogs and the potential utility in this species of clinical assessment tools and interventions developed for humans. [Display omitted]
Aging is the leading cause of disability, disease, and death in adult dogs. One major consequence of aging is diminishing physical function. For normal functioning, basic elements such as strength, balance, and energy must be present. These must then be integrated to enable higher levels of function, from simple walking and feeding to the complex demands of social roles, such as family companion or working search-and-rescue dog. Biological aging processes, such as loss of muscle strength, diminished cardiorespiratory function, chronic inflammation, and age-associated diseases, as well as the adverse effects of medical treatments, all contribute to physical dysfunction. Contextual elements, such as lack of opportunity for physical exercise or restricted access to veterinary care due to owner socioeconomic circumstances, also influence age-associated functional decline in dogs. In humans, well-established clinical assessments are available to evaluate physical function, and these can predict disability, morbidity, and mortality. There are also well-supported interventions that preserve and restore function and reduce the risk of death and disease in the elderly. Because the fundamental biology and the clinical phenotype of aging are very similar in humans and dogs, these assessments and interventions can likely be adapted for use in mitigating declining physical function in geriatric canines. This review evaluates the decline in physical function with age in dogs and the potential utility in this species of clinical assessment tools and interventions developed for humans.
ArticleNumber 100732
Author Chen, Frances L.
McKenzie, Brennen A.
Author_xml – sequence: 1
  givenname: Brennen A.
  orcidid: 0000-0003-4097-8479
  surname: McKenzie
  fullname: McKenzie, Brennen A.
  email: mckenzievmd@gmail.com, brennen@loyalfordogs.com
– sequence: 2
  givenname: Frances L.
  surname: Chen
  fullname: Chen, Frances L.
BookMark eNp9kD1PwzAQhi1UJFrgDzBFYmFJcWwnsSWWqqWAVAQDzJZjX4KjxC5xitR_T0KYGJju63lPd-8CzZx3gNBVgpcJTrLbetlr1S4JJmRo4JySEzRPBMtiwWk-G3PKY5HT7AwtQqgxzrDgfI62qxAghBZcHylnomflVAU_pS-jDejGOuuq6PXjGKxWTbQ9ON1b7yLrolU1jja-ChfotFRNgMvfeI7et_dv68d49_LwtF7tYk1p2sdUpUpoxnNdmCylhnJScF0WiiSiIBpnLE8EKXDJqQFlFOCxooXOmOLGKHqObqa9-85_HiD0srVBQ9MoB_4QJMkJTxjLeTqg13_Q2h86N1w3UAxzIZhgA0UmSnc-hA5Kue9sq7qjTLAcrZW1HK2Vo7VysnYQ3U0iGF79stDJoC04DcZ2oHtpvP1P_g1DU4Lj
CitedBy_id crossref_primary_10_3389_fvets_2023_1150590
crossref_primary_10_3390_app14135498
crossref_primary_10_1016_j_tvjl_2024_106123
crossref_primary_10_3389_fvets_2023_1217201
crossref_primary_10_3390_vetsci11050224
crossref_primary_10_3389_fvets_2023_1249951
Cites_doi 10.3389/fvets.2021.673407
10.1007/s11606-019-05106-3
10.1007/s11357-018-0036-9
10.1016/S0140-6736(08)60342-6
10.3920/CEP170007
10.1016/S0140-6736(19)31786-6
10.1016/j.cell.2013.05.039
10.1371/journal.pone.0268390
10.1001/jama.1993.03510140062030
10.1126/science.3299702
10.1097/MD.0000000000016218
10.1016/j.nmd.2016.09.024
10.1080/10888705.2010.483871
10.1007/s10745-021-00282-5
10.2522/ptj.20090322
10.3389/fgene.2019.00948
10.1186/s12916-016-0763-7
10.1007/s00520-021-06171-3
10.1016/j.cardfail.2008.10.006
10.1089/rej.2012.1397
10.1111/j.1439-0442.1997.tb01130.x
10.1007/s00520-021-06787-5
10.1111/j.1939-1676.2011.0689.x
10.1016/j.cger.2017.09.004
10.2460/javma.22.02.0088
10.1016/j.freeradbiomed.2018.08.035
10.1300/J052v15n03_02
10.1016/j.rvsc.2018.10.004
10.1177/1179572717711433
10.1007/s12603-011-0076-7
10.2460/ajvr.22.02.0027
10.1097/HJH.0000000000001214
10.1186/1471-2318-14-14
10.1017/S0029665115002037
10.1016/j.applanim.2021.105449
10.3389/fvets.2022.842458
10.1016/j.actatropica.2014.03.010
10.3390/ani12030400
10.1007/s40266-015-0288-3
10.3389/fvets.2021.654617
10.1016/j.tvjl.2018.02.017
10.1177/0891988707301865
10.1111/acel.12737
10.1093/gerona/62.7.722
10.1093/eurpub/ckab164.370
10.1016/j.exger.2014.01.024
10.1111/j.1748-3743.2007.00074.x
10.3390/geriatrics6020038
10.2460/ajvr.77.12.1357
10.1183/09031936.00059814
10.1093/gerona/61.8.851
10.1016/j.healthplace.2006.01.003
10.1038/s41598-019-52585-9
10.2460/ajvr.2004.65.311
10.1093/gerona/glw083
10.1016/j.apmr.2014.06.008
10.3402/pba.v6.33276
10.1007/s00125-017-4349-5
10.1016/j.amepre.2004.12.008
10.1093/gerona/56.3.M146
10.1002/clc.23311
10.1016/j.critrevonc.2003.07.003
10.1016/j.exger.2015.08.008
10.3390/vetsci7030097
10.1093/ageing/afs099
10.1186/s12877-020-01509-8
10.1007/s12603-020-1337-0
10.1111/jvim.12281
10.1298/ptr.E10028
10.1177/0898264314525665
10.1016/j.prevetmed.2010.01.013
10.1186/1741-7015-9-83
10.1007/s11121-013-0437-z
10.1111/jgs.14190
10.1002/9781118999196.ch22
10.1038/s41569-018-0064-2
10.3390/ani11092528
10.2460/ajvr.71.3.322
10.1177/20587392211026109
10.1111/j.1532-950X.2014.12141.x
10.1007/BF03327351
10.1093/gerona/glac099
10.1101/2022.04.20.488879
10.1016/j.applanim.2006.11.018
10.1159/000382065
10.1093/gerona/glw043
10.1093/gerona/glq167
10.1503/cmaj.061339
10.1016/S0895-4356(03)00258-0
10.1016/S0031-9384(01)00632-1
10.1186/s12917-020-02293-8
10.1007/BF03324782
10.1093/gerona/glv035
10.1007/s13670-019-0275-3
10.1371/journal.pone.0058125
10.1016/j.exger.2015.07.011
10.1136/inp.k647
10.1503/cmaj.050051
ContentType Journal Article
Copyright 2022 The Author(s)
2022. The Author(s)
Copyright_xml – notice: 2022 The Author(s)
– notice: 2022. The Author(s)
DBID 6I.
AAFTH
AAYXX
CITATION
K9.
NAPCQ
7X8
DOI 10.1016/j.tcam.2022.100732
DatabaseName ScienceDirect Open Access Titles
Elsevier:ScienceDirect:Open Access
CrossRef
ProQuest Health & Medical Complete (Alumni)
Nursing & Allied Health Premium
MEDLINE - Academic
DatabaseTitle CrossRef
ProQuest Health & Medical Complete (Alumni)
Nursing & Allied Health Premium
MEDLINE - Academic
DatabaseTitleList
ProQuest Health & Medical Complete (Alumni)
DeliveryMethod fulltext_linktorsrc
Discipline Veterinary Medicine
EISSN 1946-9837
1876-7613
EndPage 100732
ExternalDocumentID 10_1016_j_tcam_2022_100732
S1938973622001052
GroupedDBID ---
--K
--M
.~1
0R~
123
1B1
1~.
1~5
3V.
4.4
457
4G.
53G
5VS
6I.
7-5
71M
7RV
7X7
8FE
8FH
8FI
8P~
AABVA
AACTN
AAEDT
AAEDW
AAFTH
AAIAV
AAIKJ
AAKOC
AALRI
AAOAW
AAQFI
AATLK
AAXUO
ABBQC
ABGRD
ABJNI
ABLVK
ABMAC
ABMZM
ABRWV
ABXDB
ABYKQ
ACDAQ
ACGFS
ACRLP
ADBBV
ADEZE
ADMUD
ADQTV
AEBSH
AEKER
AENEX
AEQOU
AESVU
AEXOQ
AFKRA
AFKWA
AFRAH
AFTJW
AFXIZ
AGHFR
AGUBO
AGYEJ
AHMBA
AIEXJ
AIKHN
AITUG
AJBFU
AJOXV
AJRQY
ALMA_UNASSIGNED_HOLDINGS
AMFUW
AMRAJ
ANZVX
ATCPS
AXJTR
AZQEC
BENPR
BHPHI
BKEYQ
BKOJK
BLXMC
BNPGV
BPHCQ
BVXVI
C45
CBWCG
CS3
DU5
EBS
EFJIC
EFLBG
EJD
EMOBN
EO9
EP2
EP3
EX3
F5P
FDB
FEDTE
FIRID
FNPLU
FYGXN
FYUFA
GBLVA
GUQSH
HCIFZ
HVGLF
HZ~
J1W
KOM
LCYCR
M0K
M1P
M2O
M41
MO0
N9A
O-L
O9-
OAUVE
OVD
OZT
P-8
P-9
PC.
PQQKQ
PROAC
Q38
QYZTP
RIG
ROL
RPZ
SDF
SDG
SEL
SES
SNL
SPCBC
SSA
SSH
SSZ
SV3
T5K
TEORI
WOW
~G-
AAHBH
AAXKI
AAYXX
AFJKZ
AKRWK
CITATION
K9.
NAPCQ
7X8
ID FETCH-LOGICAL-c335t-3a5a9c487cbd653d382b8cfba219b2c0647192b0f83deadae092b03bc64a8dda3
IEDL.DBID .~1
ISSN 1938-9736
IngestDate Fri Oct 25 11:24:44 EDT 2024
Thu Oct 10 21:59:35 EDT 2024
Thu Sep 26 19:02:58 EDT 2024
Fri Feb 23 02:38:44 EST 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Keywords IADL
FI
TUG
ADL
SPPB
FP
healthspan
CGS
frailty
AADL
physical dysfunction
BADL
canine aging
Language English
License This is an open access article under the CC BY-NC-ND license.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c335t-3a5a9c487cbd653d382b8cfba219b2c0647192b0f83deadae092b03bc64a8dda3
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ORCID 0000-0003-4097-8479
OpenAccessLink https://www.sciencedirect.com/science/article/pii/S1938973622001052
PQID 2740899494
PQPubID 1216383
PageCount 1
ParticipantIDs proquest_miscellaneous_2728144785
proquest_journals_2740899494
crossref_primary_10_1016_j_tcam_2022_100732
elsevier_sciencedirect_doi_10_1016_j_tcam_2022_100732
PublicationCentury 2000
PublicationDate November-December 2022
2022-11-00
20221101
PublicationDateYYYYMMDD 2022-11-01
PublicationDate_xml – month: 11
  year: 2022
  text: November-December 2022
PublicationDecade 2020
PublicationPlace Philadelphia
PublicationPlace_xml – name: Philadelphia
PublicationTitle Topics in companion animal medicine
PublicationYear 2022
Publisher Elsevier Inc
Elsevier Limited
Publisher_xml – name: Elsevier Inc
– name: Elsevier Limited
References Sándor, Kubinyi (bib0046) 2019; 10
Griss, Riemer, Warembourg (bib0055) 2021; 243
Ferrucci, Cooper, Shardell, Simonsick, Schrack, Kuh (bib0021) 2016; 71
Cachon, Frykman, Innes (bib0086) 2018; 235
Lee, Collins, Creevy, Promislow, Consortium (bib0050) 2022
V.I. Rohlf, S. Toukhsati, G.J. Coleman, and P.C. Bennett, 2010. Dog Obesity: Can Dog Caregivers' (Owners') Feeding and Exercise Intentions and Behaviors Be Predicted From Attitudes?, Journal of Applied Animal Welfare Science, 13:3, 213-236, DOI: 10.1080/10888705.2010.483871.
Fung, Calzada, Saldaña (bib0063) 2014; 135
Kaeberlein (bib0007) 2018; 40
Bray EE, Raichlen DA, Forsyth KK, et al. Associations between physical activity and cognitive dysfunction in older companion dogs: results from the Dog Aging Project. GeroScience (2022). https://doi.org/10.1007/s11357-022-00655-8
Boddy, Roche, Schwartz, Nakayama, Hamlin (bib0077) 2004; 65
Halter, Reuben (bib0043) 2001
Jin, Hoffman, Creevy, O'Neill, Promislow (bib0052) 2016; 6
Sanders, Singh, Minster (bib0015) 2016; 64
Justice, Cesari, Seals, Shively, Carter (bib0033) 2016; 71
Grusdat, Stäuber, Tolkmitt (bib0041) 2022; 30
Geirsdottir, Arnarson, Briem (bib0022) 2011; 16
Lilja-Maula, Laurila, Syrjä (bib0076) 2014; 28
Thomas, Battaglia, Patti (bib0094) 2019; 98
Valencia, Palacio, Tamariz, Florez (bib0100) 2017; 60
(accessed May 18, 2022).
Gawande (bib0053) 2017
Cerqueira, Restan, Fonseca (bib0105) 2018; 121
McKenzie, Chen, Gruen, Olby (bib0019) 2022; 0
Teixeira, Fonseca, Diniz-Sousa (bib0089) 2021; 6
Barry, Galvin, Keogh, Horgan, Fahey (bib0075) 2014; 14
Gillespie, Robertson, Gillespie (bib0095) 2012; 2012
Sumukadas, Witham, Struthers, McMurdo (bib0101) 2007; 177
Zengarini, Ruggiero, Pérez-Zepeda (bib0027) 2015; 70
Brown, Michel, Love, Dow (bib0048) 2010; 71
Weiner, Weiner, Yusuf (bib0065) 1993; 270
Walston, Buta, Xue (bib0009) 2018; 34
Nakano, Fukushima, Tanaka, Fu, Morishita (bib0069) 2021; 29
Brown (bib0087) 2014; 43
C.L. Clarke and M.D. Witham, The Effects of Medication on Activity and Rehabilitation of Older People-Opportunities and Risks. Rehabilitation Process and Outcome. 2017;6. doi:10.1177/1179572717711433.
Chua, Lim, Lin, Yuan, Koh (bib0066) 2020; 24
Dominick, Ahern, Gold, Heller (bib0017) 2002; 14
Knazovicky, Tomas, Motsinger-Reif, Lascelles (bib0091) 2015; 2015
Rowe, Kahn (bib0006) 1987; 237
Belshaw, Dean, Asher (bib0026) 2020; 16
Walton, Cowderoy, Lascelles, Innes (bib0088) 2013; 8
Imamura, Kamide, Sakomoto, Sato, Shiba, Matsunga (bib0044) 2020; 23
Banzato, Franzo, Di Maggio (bib0014) 2019; 9
Beswick, Rees, Beswick (bib0098) 2008; 371
Frye, Carr, Lenfest, Miller (bib0016) 2022; 9
Moraes, Soares, Cabidelli (bib0106) 2017; 13
Walton, Cox, Innes (bib0080) 2018; 40
Bland, Guthrie-Jones, Taylor, Hill (bib0057) 2010; 94
Volpato, Cavalieri, Sioulis (bib0071) 2011; 66
Pavasini, Guralnik, Brown (bib0070) 2016; 14
M. Asim, M. Aftab, S.H. Bhatti, T. Ahmad, S.M. Ali Shah, and M. Akram, Identifying factors causing decline in physical functionality of geriatric population. European Journal of Inflammation. 2021;19. doi:10.1177/20587392211026109.
Nascimento, Ingles, Salvador-Pascual, Cominetti, Gomez-Cabrera, Viña (bib0034) 2019; 132
Väätäjä, Majaranta, Cardó (bib0054) 2021; 8
Fairhall, Langron, Sherrington (bib0096) 2011; 9
Divo, Martinez, Mannino (bib0051) 2014; 44
Hua, Hoummady, Muller (bib0013) 2016; 77
Liu, Latham (bib0093) 2009; 2009
Marinelli, Adamelli, Normando, Bono (bib0064) 2007; 108
Hollenberg, Yang, Haight, Tager (bib0037) 2006; 61
Fried, Tangen, Walston (bib0011) 2001; 56
McKenzie, Chen, LaCroix-Fralish (bib0047) 2022; 260
shan Zhou, jie Xu, qing Wang, huan Huang, Xiao (bib0099) 2015; 32
Tralongo, Respini, Ferraù (bib0030) 2003; 48
Hoffman, Creevy, Franks, O'Neill, Promislow (bib0002) 2018; 17
p. 2022.04.20.488879, 2022, doi: 10.1101/2022.04.20.488879.
C.S. Colón-Emeric, H.E. Whitson, J. Pavon, and H. Hoenig, Functional decline in older adults. Am Fam Physician. 2013 Sep 15;88(6):388-94. PMID: 24134046; PMCID: PMC3955056. Available at
Thornton, Templeman, Bower, Cant, Holloway, Shoveller (bib0104) 2020; 7
Rao (bib0090) 2019; 8
Alahdab, Mansour, Napan, Stamos (bib0073) 2009; 15
Avlund (bib0028) 2013; 22
Chien, Kuo, Wu (bib0036) 2010; 90
Goldberg (bib0085) 2017; 32
Brown, Thompson, Zack, Arnold, Barile (bib0018) 2015; 16
Linder, Santiago, Halbreich (bib0056) 2021; 8
Kriegsman, Deeg, Stalman (bib0023) 2004; 57
Strasser, Simunek, Seiser, Hofecker (bib0102) 1997; 44
Hartigan (bib0029) 2007; 2
Keevil, Romero-Ortuno (bib0035) 2015; 74
Ikpeme, Pang, Hoveling (bib0045) 2021; 31
Chowdhury, Nelson, Jennings, Wing, Reid (bib0059) 2016; 35
Eisenman, Koster, Foley, Fiorello (bib0062) 2021; 49
Yazdanyar, Aziz, Enright (bib0072) 2014; 26
Lee, Kim, Oh, Kim (bib0103) 2021; 11
McKenzie (bib0005) 2022; 83
Donoghue, Savva, Cronin, Kenny, Horgan (bib0067) 2014; 95
Ferrucci, Fabbri (bib0038) 2018; 15
O'Neill, Forman (bib0020) 2020; 43
Freiberger, De vreede, Schoene (bib0068) 2012; 41
Hielm-Björkman (bib0084) 2013
Foster (bib0081) 2013
Russo, Cesari, Onder (bib0042) 2007; 20
D. Dembicki and J. Anderson, (1996) Pet Ownership May Be a Factor in Improved Health of the Elderly, Journal of Nutrition For the Elderly, 15:3, 15-31, DOI: 10.1300/J052v15n03_02
Gilmore, Greer (bib0001) 2015; 71
Swimmer, Rozanski (bib0078) 2011; 25
López-Otín, Blasco, Partridge, Serrano, Kroemer (bib0003) 2013; 153
Ukraintseva, Yashin, Arbeev (bib0004) 2016; 71
Hoogendijk, Afilalo, Ensrud, Kowal, Onder, Fried (bib0008) 2019; 394
Cadore, Rodríguez-Mañas, Sinclair, Izquierdo (bib0092) 2013; 16
Rockwood, Song, MacKnight (bib0107) 2005; 173
Rockwood, Mitnitski (bib0012) 2007; 62
Hillsdon, Brunner, Guralnik, Marmot (bib0083) 2005; 28
Siwak, Murphey, Muggenburg, Milgram (bib0049) 2002; 75
Mondino, Wagner, Russell (bib0082) 2022; 17
Mohler, Fain, Wertheimer, Najafi, Nikolich-Žugich (bib0010) 2014; 54
Cutt, Giles-Corti, Knuiman, Burke (bib0061) 2007; 13
Aguirre, Villareal (bib0097) 2015; 83
Fulmer, Laven, Hill (bib0025) 2022; 12
Acosta, Van Wie, Stoughton (bib0079) 2016; 26
Katsimpris, Linseisen, Meisinger, Volaklis (bib0039) 2019; 34
Son, Shin, Lee, Kim, Yun, Cho (bib0074) 2020; 20
Avlund (10.1016/j.tcam.2022.100732_bib0028) 2013; 22
Divo (10.1016/j.tcam.2022.100732_bib0051) 2014; 44
Chua (10.1016/j.tcam.2022.100732_bib0066) 2020; 24
Brown (10.1016/j.tcam.2022.100732_bib0048) 2010; 71
Gillespie (10.1016/j.tcam.2022.100732_bib0095) 2012; 2012
Rockwood (10.1016/j.tcam.2022.100732_bib0107) 2005; 173
Rockwood (10.1016/j.tcam.2022.100732_bib0012) 2007; 62
Siwak (10.1016/j.tcam.2022.100732_bib0049) 2002; 75
Son (10.1016/j.tcam.2022.100732_bib0074) 2020; 20
Fried (10.1016/j.tcam.2022.100732_bib0011) 2001; 56
Walston (10.1016/j.tcam.2022.100732_bib0009) 2018; 34
McKenzie (10.1016/j.tcam.2022.100732_bib0019) 2022; 0
Weiner (10.1016/j.tcam.2022.100732_bib0065) 1993; 270
Kaeberlein (10.1016/j.tcam.2022.100732_bib0007) 2018; 40
Ferrucci (10.1016/j.tcam.2022.100732_bib0038) 2018; 15
Gawande (10.1016/j.tcam.2022.100732_bib0053) 2017
Sándor (10.1016/j.tcam.2022.100732_bib0046) 2019; 10
Cerqueira (10.1016/j.tcam.2022.100732_bib0105) 2018; 121
Volpato (10.1016/j.tcam.2022.100732_bib0071) 2011; 66
Beswick (10.1016/j.tcam.2022.100732_bib0098) 2008; 371
Hillsdon (10.1016/j.tcam.2022.100732_bib0083) 2005; 28
Rao (10.1016/j.tcam.2022.100732_bib0090) 2019; 8
Acosta (10.1016/j.tcam.2022.100732_bib0079) 2016; 26
Mondino (10.1016/j.tcam.2022.100732_bib0082) 2022; 17
Ikpeme (10.1016/j.tcam.2022.100732_bib0045) 2021; 31
Ferrucci (10.1016/j.tcam.2022.100732_bib0021) 2016; 71
Hollenberg (10.1016/j.tcam.2022.100732_bib0037) 2006; 61
Brown (10.1016/j.tcam.2022.100732_bib0087) 2014; 43
Barry (10.1016/j.tcam.2022.100732_bib0075) 2014; 14
Gilmore (10.1016/j.tcam.2022.100732_bib0001) 2015; 71
Jin (10.1016/j.tcam.2022.100732_bib0052) 2016; 6
Justice (10.1016/j.tcam.2022.100732_bib0033) 2016; 71
Eisenman (10.1016/j.tcam.2022.100732_bib0062) 2021; 49
Hoogendijk (10.1016/j.tcam.2022.100732_bib0008) 2019; 394
McKenzie (10.1016/j.tcam.2022.100732_bib0005) 2022; 83
O'Neill (10.1016/j.tcam.2022.100732_bib0020) 2020; 43
Hielm-Björkman (10.1016/j.tcam.2022.100732_bib0084) 2013
Swimmer (10.1016/j.tcam.2022.100732_bib0078) 2011; 25
Lee (10.1016/j.tcam.2022.100732_bib0050) 2022
Nascimento (10.1016/j.tcam.2022.100732_bib0034) 2019; 132
Yazdanyar (10.1016/j.tcam.2022.100732_bib0072) 2014; 26
Valencia (10.1016/j.tcam.2022.100732_bib0100) 2017; 60
10.1016/j.tcam.2022.100732_bib0060
Thornton (10.1016/j.tcam.2022.100732_bib0104) 2020; 7
Cutt (10.1016/j.tcam.2022.100732_bib0061) 2007; 13
Dominick (10.1016/j.tcam.2022.100732_bib0017) 2002; 14
10.1016/j.tcam.2022.100732_bib0058
Banzato (10.1016/j.tcam.2022.100732_bib0014) 2019; 9
Zengarini (10.1016/j.tcam.2022.100732_bib0027) 2015; 70
10.1016/j.tcam.2022.100732_bib0032
Russo (10.1016/j.tcam.2022.100732_bib0042) 2007; 20
10.1016/j.tcam.2022.100732_bib0031
Teixeira (10.1016/j.tcam.2022.100732_bib0089) 2021; 6
shan Zhou (10.1016/j.tcam.2022.100732_bib0099) 2015; 32
Fung (10.1016/j.tcam.2022.100732_bib0063) 2014; 135
Knazovicky (10.1016/j.tcam.2022.100732_bib0091) 2015; 2015
Fairhall (10.1016/j.tcam.2022.100732_bib0096) 2011; 9
Belshaw (10.1016/j.tcam.2022.100732_bib0026) 2020; 16
Liu (10.1016/j.tcam.2022.100732_bib0093) 2009; 2009
Brown (10.1016/j.tcam.2022.100732_bib0018) 2015; 16
Hoffman (10.1016/j.tcam.2022.100732_bib0002) 2018; 17
Halter (10.1016/j.tcam.2022.100732_bib0043) 2001
Boddy (10.1016/j.tcam.2022.100732_bib0077) 2004; 65
Cachon (10.1016/j.tcam.2022.100732_bib0086) 2018; 235
Chowdhury (10.1016/j.tcam.2022.100732_bib0059) 2016; 35
Aguirre (10.1016/j.tcam.2022.100732_bib0097) 2015; 83
Geirsdottir (10.1016/j.tcam.2022.100732_bib0022) 2011; 16
Rowe (10.1016/j.tcam.2022.100732_bib0006) 1987; 237
10.1016/j.tcam.2022.100732_bib0024
Pavasini (10.1016/j.tcam.2022.100732_bib0070) 2016; 14
Fulmer (10.1016/j.tcam.2022.100732_bib0025) 2022; 12
Keevil (10.1016/j.tcam.2022.100732_bib0035) 2015; 74
10.1016/j.tcam.2022.100732_bib0040
Marinelli (10.1016/j.tcam.2022.100732_bib0064) 2007; 108
Walton (10.1016/j.tcam.2022.100732_bib0088) 2013; 8
Linder (10.1016/j.tcam.2022.100732_bib0056) 2021; 8
Griss (10.1016/j.tcam.2022.100732_bib0055) 2021; 243
Donoghue (10.1016/j.tcam.2022.100732_bib0067) 2014; 95
Tralongo (10.1016/j.tcam.2022.100732_bib0030) 2003; 48
Foster (10.1016/j.tcam.2022.100732_bib0081) 2013
Cadore (10.1016/j.tcam.2022.100732_bib0092) 2013; 16
Katsimpris (10.1016/j.tcam.2022.100732_bib0039) 2019; 34
Frye (10.1016/j.tcam.2022.100732_bib0016) 2022; 9
Goldberg (10.1016/j.tcam.2022.100732_bib0085) 2017; 32
McKenzie (10.1016/j.tcam.2022.100732_bib0047) 2022; 260
Hua (10.1016/j.tcam.2022.100732_bib0013) 2016; 77
Moraes (10.1016/j.tcam.2022.100732_bib0106) 2017; 13
Mohler (10.1016/j.tcam.2022.100732_bib0010) 2014; 54
Chien (10.1016/j.tcam.2022.100732_bib0036) 2010; 90
Bland (10.1016/j.tcam.2022.100732_bib0057) 2010; 94
Strasser (10.1016/j.tcam.2022.100732_bib0102) 1997; 44
Hartigan (10.1016/j.tcam.2022.100732_bib0029) 2007; 2
Lee (10.1016/j.tcam.2022.100732_bib0103) 2021; 11
Kriegsman (10.1016/j.tcam.2022.100732_bib0023) 2004; 57
Thomas (10.1016/j.tcam.2022.100732_bib0094) 2019; 98
Sumukadas (10.1016/j.tcam.2022.100732_bib0101) 2007; 177
Nakano (10.1016/j.tcam.2022.100732_bib0069) 2021; 29
López-Otín (10.1016/j.tcam.2022.100732_bib0003) 2013; 153
Grusdat (10.1016/j.tcam.2022.100732_bib0041) 2022; 30
Freiberger (10.1016/j.tcam.2022.100732_bib0068) 2012; 41
Walton (10.1016/j.tcam.2022.100732_bib0080) 2018; 40
Ukraintseva (10.1016/j.tcam.2022.100732_bib0004) 2016; 71
Alahdab (10.1016/j.tcam.2022.100732_bib0073) 2009; 15
Lilja-Maula (10.1016/j.tcam.2022.100732_bib0076) 2014; 28
Väätäjä (10.1016/j.tcam.2022.100732_bib0054) 2021; 8
Imamura (10.1016/j.tcam.2022.100732_bib0044) 2020; 23
Sanders (10.1016/j.tcam.2022.100732_bib0015) 2016; 64
References_xml – volume: 40
  start-page: 361
  year: 2018
  ident: bib0007
  article-title: How healthy is the healthspan concept?
  publication-title: GeroScience
  contributor:
    fullname: Kaeberlein
– year: 2017
  ident: bib0053
  article-title: Being Mortal: Medicine and What Matters in the End
  contributor:
    fullname: Gawande
– volume: 22
  start-page: 100
  year: 2013
  end-page: 115
  ident: bib0028
  article-title: Fatigue in older adults: an early indicator of the aging process?
  publication-title: Aging Clin. Exp. Res.
  contributor:
    fullname: Avlund
– volume: 83
  year: 2022
  ident: bib0005
  article-title: Comparative veterinary geroscience: mechanism of molecular, cellular, and tissue aging in humans, laboratory animal models, and companion dogs and cats
  publication-title: Am. J. Vet. Res.
  contributor:
    fullname: McKenzie
– volume: 29
  start-page: 5623
  year: 2021
  end-page: 5634
  ident: bib0069
  article-title: Physical function predicts mortality in patients with cancer: a systematic review and meta-analysis of observational studies
  publication-title: Support. Care Cancer
  contributor:
    fullname: Morishita
– volume: 20
  year: 2020
  ident: bib0074
  article-title: Association of timed up and go test outcomes with future incidence of cardiovascular disease and mortality in adults aged 66 years: Korean national representative longitudinal study over 5.7 years
  publication-title: BMC Geriatr
  contributor:
    fullname: Cho
– volume: 40
  start-page: 42
  year: 2018
  end-page: 50
  ident: bib0080
  article-title: How do I know my animal got better?’ – measuring outcomes in small animal orthopaedics
  publication-title: In Pract
  contributor:
    fullname: Innes
– year: 2022
  ident: bib0050
  article-title: Age and physical activity levels in companion dogs: results from the dog aging project
  publication-title: J Gerontol. Ser. A
  contributor:
    fullname: Consortium
– volume: 65
  start-page: 311
  year: 2004
  end-page: 313
  ident: bib0077
  article-title: Evaluation of the six-minute walk test in dogs
  publication-title: Am. J. Vet. Res.
  contributor:
    fullname: Hamlin
– volume: 243
  year: 2021
  ident: bib0055
  article-title: If they could choose: how would dogs spend their days? Activity patterns in four populations of domestic dogs
  publication-title: Appl. Anim. Behav. Sci.
  contributor:
    fullname: Warembourg
– volume: 25
  start-page: 405
  year: 2011
  ident: bib0078
  article-title: Evaluation of the 6 minute walk test (6MWT) in pet dogs
  publication-title: J. Vet. Intern. Med.
  contributor:
    fullname: Rozanski
– volume: 16
  start-page: 62
  year: 2011
  end-page: 66
  ident: bib0022
  article-title: Physical function predicts improvement in quality of life in elderly Icelanders after 12 weeks of resistance exercise
  publication-title: J. Nutr. Heal. aging
  contributor:
    fullname: Briem
– year: 2001
  ident: bib0043
  article-title: Indicators of Function in the Geriatric Population
  publication-title: , E. National Research Council (US) Committee on Population; Finch CE, Vaupel JW, Kinsella K, Ed
  contributor:
    fullname: Reuben
– volume: 71
  start-page: 1533
  year: 2016
  end-page: 1534
  ident: bib0004
  article-title: Resilience versus robustness in aging
  publication-title: J Gerontol. Ser. A
  contributor:
    fullname: Arbeev
– volume: 70
  start-page: 78
  year: 2015
  end-page: 83
  ident: bib0027
  article-title: Fatigue: relevance and implications in the aging population
  publication-title: Exp. Gerontol.
  contributor:
    fullname: Pérez-Zepeda
– volume: 7
  start-page: 97
  year: 2020
  ident: bib0104
  article-title: Exercise but not supplemental dietary tryptophan influences heart rate and respiratory rate in sled dogs
  publication-title: Vet. Sci.
  contributor:
    fullname: Shoveller
– volume: 16
  start-page: 1
  year: 2020
  end-page: 8
  ident: bib0026
  article-title: Slower, shorter, sadder: a qualitative study exploring how dog walks change when the canine participant develops osteoarthritis
  publication-title: BMC Vet. Res.
  contributor:
    fullname: Asher
– volume: 66
  start-page: 89
  year: 2011
  end-page: 96
  ident: bib0071
  article-title: Predictive value of the short physical performance battery following hospitalization in older patients
  publication-title: J. Gerontol. A. Biol. Sci. Med. Sci.
  contributor:
    fullname: Sioulis
– volume: 260
  start-page: 963
  year: 2022
  end-page: 970
  ident: bib0047
  article-title: The phenotype of aging in the dog: how aging impacts the health and well-being of dogs and their caregivers
  publication-title: J Am Vet Med Assoc
  contributor:
    fullname: LaCroix-Fralish
– volume: 94
  start-page: 310
  year: 2010
  end-page: 315
  ident: bib0057
  article-title: Dog obesity: veterinary practices’ and owners’ opinions on cause and management
  publication-title: Prev. Vet. Med.
  contributor:
    fullname: Hill
– volume: 0
  start-page: 462
  year: 2022
  ident: bib0019
  article-title: Canine Geriatric Syndrome: a framework for advancing research in veterinary geroscience
  publication-title: Front. Vet. Sci.
  contributor:
    fullname: Olby
– volume: 121
  start-page: 31
  year: 2018
  end-page: 39
  ident: bib0105
  article-title: Intense exercise and endurance-training program influence serum kinetics of muscle and cardiac biomarkers in dogs
  publication-title: Res. Vet. Sci.
  contributor:
    fullname: Fonseca
– volume: 20
  start-page: 131
  year: 2007
  end-page: 137
  ident: bib0042
  article-title: Depression and physical function: results from the aging and longevity study in the Sirente geographic area (ilSIRENTE Study
  publication-title: J. Geriatr. Psychiatry Neurol.
  contributor:
    fullname: Onder
– volume: 2009
  year: 2009
  ident: bib0093
  article-title: Progressive resistance strength training for improving physical function in older adults
  publication-title: Cochrane database Syst. Rev.
  contributor:
    fullname: Latham
– volume: 71
  start-page: 322
  year: 2010
  end-page: 325
  ident: bib0048
  article-title: Evaluation of the effect of signalment and body conformation on activity monitoring in companion dogs
  publication-title: Am. J. Vet. Res.
  contributor:
    fullname: Dow
– volume: 135
  start-page: 67
  year: 2014
  end-page: 74
  ident: bib0063
  article-title: Domestic dog health worsens with socio-economic deprivation of their home communities
  publication-title: Acta Trop
  contributor:
    fullname: Saldaña
– volume: 270
  start-page: 1702
  year: 1993
  end-page: 1707
  ident: bib0065
  article-title: Prediction of mortality and morbidity with a 6-minute walk test in patients with left ventricular dysfunction
  publication-title: JAMA
  contributor:
    fullname: Yusuf
– volume: 173
  start-page: 489
  year: 2005
  end-page: 495
  ident: bib0107
  article-title: A global clinical measure of fitness and frailty in elderly people
  publication-title: CMAJ
  contributor:
    fullname: MacKnight
– volume: 74
  start-page: 337
  year: 2015
  end-page: 347
  ident: bib0035
  article-title: Ageing well: a review of sarcopenia and frailty
  publication-title: Proc. Nutr. Soc.
  contributor:
    fullname: Romero-Ortuno
– volume: 61
  start-page: 851
  year: 2006
  end-page: 858
  ident: bib0037
  article-title: Longitudinal changes in aerobic capacity: implications for concepts of aging
  publication-title: J Gerontol. Ser. A
  contributor:
    fullname: Tager
– volume: 15
  start-page: 505
  year: 2018
  end-page: 522
  ident: bib0038
  article-title: Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
  publication-title: Nat. Rev. Cardiol.
  contributor:
    fullname: Fabbri
– volume: 49
  start-page: 795
  year: 2021
  end-page: 808
  ident: bib0062
  article-title: Does wealth predict health among dogs in a protected area?
  publication-title: Hum. Ecol.
  contributor:
    fullname: Fiorello
– volume: 8
  year: 2021
  ident: bib0054
  article-title: The interplay between affect, dog's physical activity and dog–owner relationship
  publication-title: Front. Vet. Sci.
  contributor:
    fullname: Cardó
– volume: 44
  start-page: 1055
  year: 2014
  end-page: 1068
  ident: bib0051
  article-title: Ageing and the epidemiology of multimorbidity
  publication-title: Eur. Respir. J.
  contributor:
    fullname: Mannino
– volume: 12
  start-page: 400
  year: 2022
  ident: bib0025
  article-title: Quality of life measurement in dogs and cats: a scoping review of generic tools
  publication-title: Animals
  contributor:
    fullname: Hill
– volume: 13
  start-page: 217
  year: 2017
  end-page: 226
  ident: bib0106
  article-title: Effects of resistance training on electrocardiographic and blood parameters of police dogs
  publication-title: Comp. Exerc. Physiol.
  contributor:
    fullname: Cabidelli
– volume: 32
  start-page: 37
  year: 2017
  end-page: 44
  ident: bib0085
  article-title: A look at chronic pain in dogs
  publication-title: new pub Salt Media/Latcham
  contributor:
    fullname: Goldberg
– volume: 98
  start-page: 1
  year: 2019
  end-page: 9
  ident: bib0094
  article-title: Physical activity programs for balance and fall prevention in elderly: a systematic review
  publication-title: Medicine (Baltimore)
  contributor:
    fullname: Patti
– volume: 57
  start-page: 55
  year: 2004
  end-page: 65
  ident: bib0023
  article-title: Comorbidity of somatic chronic diseases and decline in physical functioning: the Longitudinal Aging Study Amsterdam
  publication-title: J. Clin. Epidemiol.
  contributor:
    fullname: Stalman
– volume: 24
  start-page: 371
  year: 2020
  end-page: 378
  ident: bib0066
  article-title: Handgrip strength and Timed Up-and-Go (TUG) test are predictors of short-term mortality among elderly in a population-based cohort in Singapore
  publication-title: J. Nutr. Health Aging
  contributor:
    fullname: Koh
– volume: 32
  start-page: 727
  year: 2015
  end-page: 735
  ident: bib0099
  article-title: Effect of angiotensin-converting enzyme inhibitors on physical function in elderly subjects: a systematic review and meta-analysis
  publication-title: Drugs Aging
  contributor:
    fullname: Xiao
– volume: 10
  year: 2019
  ident: bib0046
  article-title: Genetic pathways of aging and their relevance in the dog as a natural model of human aging
  publication-title: Front Genet
  contributor:
    fullname: Kubinyi
– volume: 14
  start-page: 499
  year: 2002
  end-page: 508
  ident: bib0017
  article-title: Relationship of health-related quality of life to health care utilization and mortality among older adults
  publication-title: Aging Clin. Exp. Res.
  contributor:
    fullname: Heller
– volume: 95
  start-page: 1954
  year: 2014
  end-page: 1961
  ident: bib0067
  article-title: Using timed up and go and usual gait speed to predict incident disability in daily activities among community-dwelling adults aged 65 and older
  publication-title: Arch. Phys. Med. Rehabil.
  contributor:
    fullname: Horgan
– volume: 26
  start-page: 865
  year: 2016
  end-page: 872
  ident: bib0079
  article-title: Use of the six-minute walk test to characterize golden retriever muscular dystrophy
  publication-title: Neuromuscul. Disord.
  contributor:
    fullname: Stoughton
– volume: 35
  start-page: 769
  year: 2016
  end-page: 775
  ident: bib0059
  article-title: Pet ownership and survival in the elderly hypertensive population
  publication-title: J. Hypertens.
  contributor:
    fullname: Reid
– volume: 153
  start-page: 1194
  year: 2013
  end-page: 1217
  ident: bib0003
  article-title: The hallmarks of aging
  publication-title: Cell
  contributor:
    fullname: Kroemer
– volume: 30
  start-page: 3733
  year: 2022
  end-page: 3744
  ident: bib0041
  article-title: Routine cancer treatments and their impact on physical function, symptoms of cancer-related fatigue, anxiety, and depression
  publication-title: Support. Care Cancer
  contributor:
    fullname: Tolkmitt
– volume: 28
  start-page: 245
  year: 2005
  end-page: 250
  ident: bib0083
  article-title: Prospective study of physical activity and physical function in early old age
  publication-title: Am. J. Prev. Med.
  contributor:
    fullname: Marmot
– volume: 17
  year: 2018
  ident: bib0002
  article-title: The companion dog as a model for human aging and mortality
  publication-title: Aging Cell
  contributor:
    fullname: Promislow
– volume: 34
  start-page: 1865
  year: 2019
  end-page: 1873
  ident: bib0039
  article-title: The association between polypharmacy and physical function in older adults: a systematic review
  publication-title: J. Gen. Intern. Med.
  contributor:
    fullname: Volaklis
– volume: 8
  start-page: e58125
  year: 2013
  ident: bib0088
  article-title: Evaluation of construct and criterion validity for the ‘Liverpool Osteoarthritis in Dogs’ (LOAD) Clinical Metrology Instrument and Comparison to Two Other Instruments
  publication-title: PLoS One
  contributor:
    fullname: Innes
– volume: 71
  start-page: 14
  year: 2015
  end-page: 20
  ident: bib0001
  article-title: Why is the dog an ideal model for aging research?
  publication-title: Exp. Gerontol.
  contributor:
    fullname: Greer
– volume: 14
  year: 2016
  ident: bib0070
  article-title: Short physical performance battery and all-cause mortality: systematic review and meta-analysis
  publication-title: BMC Med
  contributor:
    fullname: Brown
– volume: 43
  start-page: 241
  year: 2014
  end-page: 246
  ident: bib0087
  article-title: The Canine Orthopedic Index. Step 2: psychometric testing
  publication-title: Vet. Surg.
  contributor:
    fullname: Brown
– volume: 9
  start-page: 90
  year: 2022
  ident: bib0016
  article-title: Canine geriatric rehabilitation: considerations and strategies for assessment, functional scoring, and follow up
  publication-title: Front. Vet. Sci.
  contributor:
    fullname: Miller
– volume: 11
  start-page: 2528
  year: 2021
  ident: bib0103
  article-title: Effects of interval exercise training on serum biochemistry and bone mineral density in dogs
  publication-title: Anim.
  contributor:
    fullname: Kim
– volume: 56
  year: 2001
  ident: bib0011
  article-title: Frailty in older adults: evidence for a phenotype
  publication-title: J. Gerontol. A. Biol. Sci. Med. Sci.
  contributor:
    fullname: Walston
– volume: 44
  start-page: 449
  year: 1997
  end-page: 460
  ident: bib0102
  article-title: Age-dependent changes in cardiovascular and metabolic responses to exercise in beagle dogs
  publication-title: J. Vet. Med. Ser. A
  contributor:
    fullname: Hofecker
– volume: 71
  start-page: 1184
  year: 2016
  end-page: 1194
  ident: bib0021
  article-title: Age-related change in mobility: perspectives from life course epidemiology and geroscience
  publication-title: J. Gerontol. A. Biol. Sci. Med. Sci.
  contributor:
    fullname: Kuh
– volume: 75
  start-page: 65
  year: 2002
  end-page: 70
  ident: bib0049
  article-title: Age-dependent decline in locomotor activity in dogs is environment specific
  publication-title: Physiol. Behav.
  contributor:
    fullname: Milgram
– volume: 108
  start-page: 143
  year: 2007
  end-page: 156
  ident: bib0064
  article-title: Quality of life of the pet dog: influence of owner and dog's characteristics
  publication-title: Appl. Anim. Behav. Sci.
  contributor:
    fullname: Bono
– volume: 43
  start-page: 108
  year: 2020
  end-page: 117
  ident: bib0020
  article-title: The importance of physical function as a clinical outcome: assessment and enhancement
  publication-title: Clin. Cardiol.
  contributor:
    fullname: Forman
– volume: 14
  start-page: 1
  year: 2014
  end-page: 14
  ident: bib0075
  article-title: Is the timed up and go test a useful predictor of risk of falls in community dwelling older adults: a systematic review and meta- analysis
  publication-title: BMC Geriatr
  contributor:
    fullname: Fahey
– volume: 83
  start-page: 83
  year: 2015
  end-page: 92
  ident: bib0097
  article-title: Physical exercise as therapy for frailty
  publication-title: Nestle Nutr. Inst. Workshop Ser.
  contributor:
    fullname: Villareal
– volume: 60
  start-page: 1630
  year: 2017
  ident: bib0100
  article-title: Metformin and ageing: improving ageing outcomes beyond glycaemic control
  publication-title: Diabetologia
  contributor:
    fullname: Florez
– volume: 16
  start-page: 21
  year: 2015
  end-page: 30
  ident: bib0018
  article-title: Associations between health-related quality of life and mortality in older adults
  publication-title: Prev. Sci.
  contributor:
    fullname: Barile
– volume: 62
  start-page: 722
  year: 2007
  end-page: 727
  ident: bib0012
  article-title: Frailty in relation to the accumulation of deficits
  publication-title: J. Gerontol. A. Biol. Sci. Med. Sci.
  contributor:
    fullname: Mitnitski
– volume: 8
  start-page: 55
  year: 2019
  end-page: 66
  ident: bib0090
  article-title: Wearable sensor technology to measure Physical Activity (PA) in the elderly
  publication-title: Curr. Geriatr. Reports
  contributor:
    fullname: Rao
– volume: 371
  start-page: 725
  year: 2008
  end-page: 735
  ident: bib0098
  article-title: Complex interventions to improve physical function and maintain independent living in elderly people: a systematic review and meta-analysis
  publication-title: Lancet
  contributor:
    fullname: Beswick
– volume: 6
  start-page: 33276
  year: 2016
  ident: bib0052
  article-title: Multiple morbidities in companion dogs: a novel model for investigating age-related disease
  publication-title: Pathobiol. Aging Age Relat. Dis.
  contributor:
    fullname: Promislow
– volume: 2015
  year: 2015
  ident: bib0091
  article-title: Initial evaluation of nighttime restlessness in a naturally occurring canine model of osteoarthritis pain
  publication-title: PeerJ
  contributor:
    fullname: Lascelles
– volume: 8
  start-page: 736
  year: 2021
  ident: bib0056
  article-title: Is there a correlation between dog obesity and human obesity? Preliminary findings of overweight status among dog owners and their dogs
  publication-title: Front. Vet. Sci.
  contributor:
    fullname: Halbreich
– volume: 2
  start-page: 204
  year: 2007
  end-page: 212
  ident: bib0029
  article-title: A comparative review of the Katz ADL and the Barthel Index in assessing the activities of daily living of older people
  publication-title: Int. J. Older People Nurs.
  contributor:
    fullname: Hartigan
– volume: 41
  start-page: 712
  year: 2012
  end-page: 721
  ident: bib0068
  article-title: Performance-based physical function in older community-dwelling persons: a systematic review of instruments
  publication-title: Age Ageing
  contributor:
    fullname: Schoene
– volume: 77
  year: 2016
  ident: bib0013
  article-title: Assessment of frailty in aged dogs
  publication-title: Am. J. Vet. Res.
  contributor:
    fullname: Muller
– volume: 54
  start-page: 6
  year: 2014
  end-page: 13
  ident: bib0010
  article-title: The Frailty syndrome: clinical measurements and basic underpinnings in humans and animals
  publication-title: Exp. Gerontol.
  contributor:
    fullname: Nikolich-Žugich
– volume: 9
  start-page: 1
  year: 2011
  end-page: 7
  ident: bib0096
  article-title: Treating frailty-a practical guide
  publication-title: BMC Med
  contributor:
    fullname: Sherrington
– volume: 31
  year: 2021
  ident: bib0045
  article-title: Physical activity determinants in older people: an analysis of the UK understanding society wave 2
  publication-title: Eur. J. Public Health
  contributor:
    fullname: Hoveling
– volume: 23
  start-page: 153
  year: 2020
  ident: bib0044
  article-title: Association between social network and physical function in community-dwelling older adults in Japan
  publication-title: Phys. Ther. Res.
  contributor:
    fullname: Matsunga
– volume: 16
  start-page: 105
  year: 2013
  end-page: 114
  ident: bib0092
  article-title: Effects of different exercise interventions on risk of falls, gait ability, and balance in physically frail older adults: a systematic review
  publication-title: Rejuvenation Res
  contributor:
    fullname: Izquierdo
– volume: 71
  start-page: 1243
  year: 2016
  ident: bib0033
  article-title: Editor's choice: comparative approaches to understanding the relation between aging and physical function
  publication-title: J Gerontol. Ser. A Biol. Sci. Med. Sci.
  contributor:
    fullname: Carter
– volume: 2012
  year: 2012
  ident: bib0095
  article-title: Interventions for preventing falls in older people living in the community
  publication-title: Cochrane Database Syst. Rev.
  contributor:
    fullname: Gillespie
– volume: 17
  year: 2022
  ident: bib0082
  article-title: Static posturography as a novel measure of the effects of aging on postural control in dogs
  publication-title: PLoS One
  contributor:
    fullname: Russell
– volume: 394
  start-page: 1365
  year: 2019
  end-page: 1375
  ident: bib0008
  article-title: Frailty: implications for clinical practice and public health
  publication-title: Lancet (London, England)
  contributor:
    fullname: Fried
– volume: 13
  start-page: 261
  year: 2007
  end-page: 272
  ident: bib0061
  article-title: Dog ownership, health and physical activity: a critical review of the literature
  publication-title: Health Place
  contributor:
    fullname: Burke
– volume: 235
  start-page: 1
  year: 2018
  end-page: 8
  ident: bib0086
  article-title: Face validity of a proposed tool for staging canine osteoarthritis: Canine OsteoArthritis Staging Tool (COAST
  publication-title: Vet. J.
  contributor:
    fullname: Innes
– volume: 48
  start-page: S57
  year: 2003
  end-page: S64
  ident: bib0030
  article-title: Fatigue and aging
  publication-title: Crit. Rev. Oncol. Hematol.
  contributor:
    fullname: Ferraù
– volume: 34
  start-page: 25
  year: 2018
  ident: bib0009
  article-title: Frailty screening and interventions: considerations for clinical practice
  publication-title: Clin. Geriatr. Med.
  contributor:
    fullname: Xue
– volume: 6
  start-page: 38
  year: 2021
  ident: bib0089
  article-title: Wearable devices for physical activity and healthcare monitoring in elderly people: a critical review
  publication-title: Geriatr.
  contributor:
    fullname: Diniz-Sousa
– volume: 64
  start-page: 1679
  year: 2016
  ident: bib0015
  article-title: Association with mortality and heritability of the Scale of Aging Vigor in Epidemiology (SAVE)
  publication-title: J. Am. Geriatr. Soc.
  contributor:
    fullname: Minster
– year: 2013
  ident: bib0081
  article-title: Canine Cross Training : Building Balance, Strength, and Endurance in Your Dog
  contributor:
    fullname: Foster
– volume: 90
  start-page: 1277
  year: 2010
  end-page: 1287
  ident: bib0036
  article-title: Sarcopenia, cardiopulmonary fitness, and physical disability in community-dwelling elderly people
  publication-title: Phys. Ther.
  contributor:
    fullname: Wu
– volume: 9
  start-page: 16749
  year: 2019
  ident: bib0014
  article-title: A Frailty Index based on clinical data to quantify mortality risk in dogs
  publication-title: Sci. Rep.
  contributor:
    fullname: Di Maggio
– start-page: 227
  year: 2013
  end-page: 237
  ident: bib0084
  article-title: Recognition and Assessment of chronic pain in dogs
  publication-title: Pain Manag. Vet. Pract.
  contributor:
    fullname: Hielm-Björkman
– volume: 15
  start-page: 130
  year: 2009
  end-page: 135
  ident: bib0073
  article-title: Six minute walk test predicts long-term all-cause mortality and heart failure rehospitalization in African-American patients hospitalized with acute decompensated heart failure
  publication-title: J. Card. Fail.
  contributor:
    fullname: Stamos
– volume: 132
  start-page: 42
  year: 2019
  end-page: 49
  ident: bib0034
  article-title: Sarcopenia, frailty and their prevention by exercise,”
  publication-title: Free Radic. Biol. Med.
  contributor:
    fullname: Viña
– volume: 28
  start-page: 379
  year: 2014
  end-page: 385
  ident: bib0076
  article-title: Long-term outcome and use of 6-minute walk test in West Highland White Terriers with idiopathic pulmonary fibrosis
  publication-title: J. Vet. Intern. Med.
  contributor:
    fullname: Syrjä
– volume: 237
  start-page: 143
  year: 1987
  end-page: 150
  ident: bib0006
  article-title: Human aging: usual and successful
  publication-title: Science (80-.)
  contributor:
    fullname: Kahn
– volume: 26
  start-page: 583
  year: 2014
  ident: bib0072
  article-title: Association between six minute walk test and all-cause mortality, coronary heart disease-specific mortality, and incident coronary heart disease
  publication-title: J. Aging Health
  contributor:
    fullname: Enright
– volume: 177
  start-page: 867
  year: 2007
  end-page: 874
  ident: bib0101
  article-title: Effect of perindopril on physical function in elderly people with functional impairment: a randomized controlled trial
  publication-title: CMAJ
  contributor:
    fullname: McMurdo
– volume: 8
  year: 2021
  ident: 10.1016/j.tcam.2022.100732_bib0054
  article-title: The interplay between affect, dog's physical activity and dog–owner relationship
  publication-title: Front. Vet. Sci.
  doi: 10.3389/fvets.2021.673407
  contributor:
    fullname: Väätäjä
– volume: 34
  start-page: 1865
  year: 2019
  ident: 10.1016/j.tcam.2022.100732_bib0039
  article-title: The association between polypharmacy and physical function in older adults: a systematic review
  publication-title: J. Gen. Intern. Med.
  doi: 10.1007/s11606-019-05106-3
  contributor:
    fullname: Katsimpris
– volume: 40
  start-page: 361
  year: 2018
  ident: 10.1016/j.tcam.2022.100732_bib0007
  article-title: How healthy is the healthspan concept?
  publication-title: GeroScience
  doi: 10.1007/s11357-018-0036-9
  contributor:
    fullname: Kaeberlein
– volume: 371
  start-page: 725
  year: 2008
  ident: 10.1016/j.tcam.2022.100732_bib0098
  article-title: Complex interventions to improve physical function and maintain independent living in elderly people: a systematic review and meta-analysis
  publication-title: Lancet
  doi: 10.1016/S0140-6736(08)60342-6
  contributor:
    fullname: Beswick
– volume: 13
  start-page: 217
  year: 2017
  ident: 10.1016/j.tcam.2022.100732_bib0106
  article-title: Effects of resistance training on electrocardiographic and blood parameters of police dogs
  publication-title: Comp. Exerc. Physiol.
  doi: 10.3920/CEP170007
  contributor:
    fullname: Moraes
– volume: 394
  start-page: 1365
  year: 2019
  ident: 10.1016/j.tcam.2022.100732_bib0008
  article-title: Frailty: implications for clinical practice and public health
  publication-title: Lancet (London, England)
  doi: 10.1016/S0140-6736(19)31786-6
  contributor:
    fullname: Hoogendijk
– volume: 153
  start-page: 1194
  year: 2013
  ident: 10.1016/j.tcam.2022.100732_bib0003
  article-title: The hallmarks of aging
  publication-title: Cell
  doi: 10.1016/j.cell.2013.05.039
  contributor:
    fullname: López-Otín
– volume: 17
  year: 2022
  ident: 10.1016/j.tcam.2022.100732_bib0082
  article-title: Static posturography as a novel measure of the effects of aging on postural control in dogs
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0268390
  contributor:
    fullname: Mondino
– volume: 270
  start-page: 1702
  year: 1993
  ident: 10.1016/j.tcam.2022.100732_bib0065
  article-title: Prediction of mortality and morbidity with a 6-minute walk test in patients with left ventricular dysfunction
  publication-title: JAMA
  doi: 10.1001/jama.1993.03510140062030
  contributor:
    fullname: Weiner
– volume: 237
  start-page: 143
  year: 1987
  ident: 10.1016/j.tcam.2022.100732_bib0006
  article-title: Human aging: usual and successful
  publication-title: Science (80-.)
  doi: 10.1126/science.3299702
  contributor:
    fullname: Rowe
– volume: 98
  start-page: 1
  year: 2019
  ident: 10.1016/j.tcam.2022.100732_bib0094
  article-title: Physical activity programs for balance and fall prevention in elderly: a systematic review
  publication-title: Medicine (Baltimore)
  doi: 10.1097/MD.0000000000016218
  contributor:
    fullname: Thomas
– volume: 26
  start-page: 865
  year: 2016
  ident: 10.1016/j.tcam.2022.100732_bib0079
  article-title: Use of the six-minute walk test to characterize golden retriever muscular dystrophy
  publication-title: Neuromuscul. Disord.
  doi: 10.1016/j.nmd.2016.09.024
  contributor:
    fullname: Acosta
– ident: 10.1016/j.tcam.2022.100732_bib0032
– ident: 10.1016/j.tcam.2022.100732_bib0058
  doi: 10.1080/10888705.2010.483871
– volume: 2009
  year: 2009
  ident: 10.1016/j.tcam.2022.100732_bib0093
  article-title: Progressive resistance strength training for improving physical function in older adults
  publication-title: Cochrane database Syst. Rev.
  contributor:
    fullname: Liu
– volume: 49
  start-page: 795
  year: 2021
  ident: 10.1016/j.tcam.2022.100732_bib0062
  article-title: Does wealth predict health among dogs in a protected area?
  publication-title: Hum. Ecol.
  doi: 10.1007/s10745-021-00282-5
  contributor:
    fullname: Eisenman
– volume: 90
  start-page: 1277
  year: 2010
  ident: 10.1016/j.tcam.2022.100732_bib0036
  article-title: Sarcopenia, cardiopulmonary fitness, and physical disability in community-dwelling elderly people
  publication-title: Phys. Ther.
  doi: 10.2522/ptj.20090322
  contributor:
    fullname: Chien
– volume: 10
  year: 2019
  ident: 10.1016/j.tcam.2022.100732_bib0046
  article-title: Genetic pathways of aging and their relevance in the dog as a natural model of human aging
  publication-title: Front Genet
  doi: 10.3389/fgene.2019.00948
  contributor:
    fullname: Sándor
– volume: 14
  year: 2016
  ident: 10.1016/j.tcam.2022.100732_bib0070
  article-title: Short physical performance battery and all-cause mortality: systematic review and meta-analysis
  publication-title: BMC Med
  doi: 10.1186/s12916-016-0763-7
  contributor:
    fullname: Pavasini
– volume: 29
  start-page: 5623
  year: 2021
  ident: 10.1016/j.tcam.2022.100732_bib0069
  article-title: Physical function predicts mortality in patients with cancer: a systematic review and meta-analysis of observational studies
  publication-title: Support. Care Cancer
  doi: 10.1007/s00520-021-06171-3
  contributor:
    fullname: Nakano
– volume: 15
  start-page: 130
  year: 2009
  ident: 10.1016/j.tcam.2022.100732_bib0073
  article-title: Six minute walk test predicts long-term all-cause mortality and heart failure rehospitalization in African-American patients hospitalized with acute decompensated heart failure
  publication-title: J. Card. Fail.
  doi: 10.1016/j.cardfail.2008.10.006
  contributor:
    fullname: Alahdab
– volume: 16
  start-page: 105
  year: 2013
  ident: 10.1016/j.tcam.2022.100732_bib0092
  article-title: Effects of different exercise interventions on risk of falls, gait ability, and balance in physically frail older adults: a systematic review
  publication-title: Rejuvenation Res
  doi: 10.1089/rej.2012.1397
  contributor:
    fullname: Cadore
– volume: 44
  start-page: 449
  year: 1997
  ident: 10.1016/j.tcam.2022.100732_bib0102
  article-title: Age-dependent changes in cardiovascular and metabolic responses to exercise in beagle dogs
  publication-title: J. Vet. Med. Ser. A
  doi: 10.1111/j.1439-0442.1997.tb01130.x
  contributor:
    fullname: Strasser
– volume: 30
  start-page: 3733
  year: 2022
  ident: 10.1016/j.tcam.2022.100732_bib0041
  article-title: Routine cancer treatments and their impact on physical function, symptoms of cancer-related fatigue, anxiety, and depression
  publication-title: Support. Care Cancer
  doi: 10.1007/s00520-021-06787-5
  contributor:
    fullname: Grusdat
– volume: 25
  start-page: 405
  year: 2011
  ident: 10.1016/j.tcam.2022.100732_bib0078
  article-title: Evaluation of the 6 minute walk test (6MWT) in pet dogs
  publication-title: J. Vet. Intern. Med.
  doi: 10.1111/j.1939-1676.2011.0689.x
  contributor:
    fullname: Swimmer
– volume: 34
  start-page: 25
  year: 2018
  ident: 10.1016/j.tcam.2022.100732_bib0009
  article-title: Frailty screening and interventions: considerations for clinical practice
  publication-title: Clin. Geriatr. Med.
  doi: 10.1016/j.cger.2017.09.004
  contributor:
    fullname: Walston
– volume: 260
  start-page: 963
  year: 2022
  ident: 10.1016/j.tcam.2022.100732_bib0047
  article-title: The phenotype of aging in the dog: how aging impacts the health and well-being of dogs and their caregivers
  publication-title: J Am Vet Med Assoc
  doi: 10.2460/javma.22.02.0088
  contributor:
    fullname: McKenzie
– volume: 132
  start-page: 42
  year: 2019
  ident: 10.1016/j.tcam.2022.100732_bib0034
  article-title: Sarcopenia, frailty and their prevention by exercise,”
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2018.08.035
  contributor:
    fullname: Nascimento
– ident: 10.1016/j.tcam.2022.100732_bib0060
  doi: 10.1300/J052v15n03_02
– volume: 121
  start-page: 31
  year: 2018
  ident: 10.1016/j.tcam.2022.100732_bib0105
  article-title: Intense exercise and endurance-training program influence serum kinetics of muscle and cardiac biomarkers in dogs
  publication-title: Res. Vet. Sci.
  doi: 10.1016/j.rvsc.2018.10.004
  contributor:
    fullname: Cerqueira
– ident: 10.1016/j.tcam.2022.100732_bib0040
  doi: 10.1177/1179572717711433
– volume: 16
  start-page: 62
  year: 2011
  ident: 10.1016/j.tcam.2022.100732_bib0022
  article-title: Physical function predicts improvement in quality of life in elderly Icelanders after 12 weeks of resistance exercise
  publication-title: J. Nutr. Heal. aging
  doi: 10.1007/s12603-011-0076-7
  contributor:
    fullname: Geirsdottir
– volume: 83
  year: 2022
  ident: 10.1016/j.tcam.2022.100732_bib0005
  article-title: Comparative veterinary geroscience: mechanism of molecular, cellular, and tissue aging in humans, laboratory animal models, and companion dogs and cats
  publication-title: Am. J. Vet. Res.
  doi: 10.2460/ajvr.22.02.0027
  contributor:
    fullname: McKenzie
– volume: 35
  start-page: 769
  year: 2016
  ident: 10.1016/j.tcam.2022.100732_bib0059
  article-title: Pet ownership and survival in the elderly hypertensive population
  publication-title: J. Hypertens.
  doi: 10.1097/HJH.0000000000001214
  contributor:
    fullname: Chowdhury
– volume: 14
  start-page: 1
  year: 2014
  ident: 10.1016/j.tcam.2022.100732_bib0075
  article-title: Is the timed up and go test a useful predictor of risk of falls in community dwelling older adults: a systematic review and meta- analysis
  publication-title: BMC Geriatr
  doi: 10.1186/1471-2318-14-14
  contributor:
    fullname: Barry
– volume: 74
  start-page: 337
  year: 2015
  ident: 10.1016/j.tcam.2022.100732_bib0035
  article-title: Ageing well: a review of sarcopenia and frailty
  publication-title: Proc. Nutr. Soc.
  doi: 10.1017/S0029665115002037
  contributor:
    fullname: Keevil
– volume: 243
  year: 2021
  ident: 10.1016/j.tcam.2022.100732_bib0055
  article-title: If they could choose: how would dogs spend their days? Activity patterns in four populations of domestic dogs
  publication-title: Appl. Anim. Behav. Sci.
  doi: 10.1016/j.applanim.2021.105449
  contributor:
    fullname: Griss
– volume: 9
  start-page: 90
  year: 2022
  ident: 10.1016/j.tcam.2022.100732_bib0016
  article-title: Canine geriatric rehabilitation: considerations and strategies for assessment, functional scoring, and follow up
  publication-title: Front. Vet. Sci.
  doi: 10.3389/fvets.2022.842458
  contributor:
    fullname: Frye
– volume: 135
  start-page: 67
  year: 2014
  ident: 10.1016/j.tcam.2022.100732_bib0063
  article-title: Domestic dog health worsens with socio-economic deprivation of their home communities
  publication-title: Acta Trop
  doi: 10.1016/j.actatropica.2014.03.010
  contributor:
    fullname: Fung
– volume: 12
  start-page: 400
  year: 2022
  ident: 10.1016/j.tcam.2022.100732_bib0025
  article-title: Quality of life measurement in dogs and cats: a scoping review of generic tools
  publication-title: Animals
  doi: 10.3390/ani12030400
  contributor:
    fullname: Fulmer
– volume: 32
  start-page: 727
  year: 2015
  ident: 10.1016/j.tcam.2022.100732_bib0099
  article-title: Effect of angiotensin-converting enzyme inhibitors on physical function in elderly subjects: a systematic review and meta-analysis
  publication-title: Drugs Aging
  doi: 10.1007/s40266-015-0288-3
  contributor:
    fullname: shan Zhou
– volume: 8
  start-page: 736
  year: 2021
  ident: 10.1016/j.tcam.2022.100732_bib0056
  article-title: Is there a correlation between dog obesity and human obesity? Preliminary findings of overweight status among dog owners and their dogs
  publication-title: Front. Vet. Sci.
  doi: 10.3389/fvets.2021.654617
  contributor:
    fullname: Linder
– volume: 235
  start-page: 1
  year: 2018
  ident: 10.1016/j.tcam.2022.100732_bib0086
  article-title: Face validity of a proposed tool for staging canine osteoarthritis: Canine OsteoArthritis Staging Tool (COAST
  publication-title: Vet. J.
  doi: 10.1016/j.tvjl.2018.02.017
  contributor:
    fullname: Cachon
– volume: 20
  start-page: 131
  year: 2007
  ident: 10.1016/j.tcam.2022.100732_bib0042
  article-title: Depression and physical function: results from the aging and longevity study in the Sirente geographic area (ilSIRENTE Study
  publication-title: J. Geriatr. Psychiatry Neurol.
  doi: 10.1177/0891988707301865
  contributor:
    fullname: Russo
– volume: 17
  year: 2018
  ident: 10.1016/j.tcam.2022.100732_bib0002
  article-title: The companion dog as a model for human aging and mortality
  publication-title: Aging Cell
  doi: 10.1111/acel.12737
  contributor:
    fullname: Hoffman
– volume: 62
  start-page: 722
  year: 2007
  ident: 10.1016/j.tcam.2022.100732_bib0012
  article-title: Frailty in relation to the accumulation of deficits
  publication-title: J. Gerontol. A. Biol. Sci. Med. Sci.
  doi: 10.1093/gerona/62.7.722
  contributor:
    fullname: Rockwood
– volume: 31
  issue: Supplement_3
  year: 2021
  ident: 10.1016/j.tcam.2022.100732_bib0045
  article-title: Physical activity determinants in older people: an analysis of the UK understanding society wave 2
  publication-title: Eur. J. Public Health
  doi: 10.1093/eurpub/ckab164.370
  contributor:
    fullname: Ikpeme
– volume: 54
  start-page: 6
  year: 2014
  ident: 10.1016/j.tcam.2022.100732_bib0010
  article-title: The Frailty syndrome: clinical measurements and basic underpinnings in humans and animals
  publication-title: Exp. Gerontol.
  doi: 10.1016/j.exger.2014.01.024
  contributor:
    fullname: Mohler
– volume: 2
  start-page: 204
  year: 2007
  ident: 10.1016/j.tcam.2022.100732_bib0029
  article-title: A comparative review of the Katz ADL and the Barthel Index in assessing the activities of daily living of older people
  publication-title: Int. J. Older People Nurs.
  doi: 10.1111/j.1748-3743.2007.00074.x
  contributor:
    fullname: Hartigan
– volume: 6
  start-page: 38
  year: 2021
  ident: 10.1016/j.tcam.2022.100732_bib0089
  article-title: Wearable devices for physical activity and healthcare monitoring in elderly people: a critical review
  publication-title: Geriatr.
  doi: 10.3390/geriatrics6020038
  contributor:
    fullname: Teixeira
– volume: 77
  year: 2016
  ident: 10.1016/j.tcam.2022.100732_bib0013
  article-title: Assessment of frailty in aged dogs
  publication-title: Am. J. Vet. Res.
  doi: 10.2460/ajvr.77.12.1357
  contributor:
    fullname: Hua
– volume: 44
  start-page: 1055
  year: 2014
  ident: 10.1016/j.tcam.2022.100732_bib0051
  article-title: Ageing and the epidemiology of multimorbidity
  publication-title: Eur. Respir. J.
  doi: 10.1183/09031936.00059814
  contributor:
    fullname: Divo
– year: 2017
  ident: 10.1016/j.tcam.2022.100732_bib0053
  contributor:
    fullname: Gawande
– year: 2001
  ident: 10.1016/j.tcam.2022.100732_bib0043
  article-title: Indicators of Function in the Geriatric Population
  contributor:
    fullname: Halter
– volume: 61
  start-page: 851
  year: 2006
  ident: 10.1016/j.tcam.2022.100732_bib0037
  article-title: Longitudinal changes in aerobic capacity: implications for concepts of aging
  publication-title: J Gerontol. Ser. A
  doi: 10.1093/gerona/61.8.851
  contributor:
    fullname: Hollenberg
– volume: 13
  start-page: 261
  year: 2007
  ident: 10.1016/j.tcam.2022.100732_bib0061
  article-title: Dog ownership, health and physical activity: a critical review of the literature
  publication-title: Health Place
  doi: 10.1016/j.healthplace.2006.01.003
  contributor:
    fullname: Cutt
– volume: 0
  start-page: 462
  year: 2022
  ident: 10.1016/j.tcam.2022.100732_bib0019
  article-title: Canine Geriatric Syndrome: a framework for advancing research in veterinary geroscience
  publication-title: Front. Vet. Sci.
  contributor:
    fullname: McKenzie
– volume: 9
  start-page: 16749
  year: 2019
  ident: 10.1016/j.tcam.2022.100732_bib0014
  article-title: A Frailty Index based on clinical data to quantify mortality risk in dogs
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-019-52585-9
  contributor:
    fullname: Banzato
– volume: 65
  start-page: 311
  year: 2004
  ident: 10.1016/j.tcam.2022.100732_bib0077
  article-title: Evaluation of the six-minute walk test in dogs
  publication-title: Am. J. Vet. Res.
  doi: 10.2460/ajvr.2004.65.311
  contributor:
    fullname: Boddy
– volume: 71
  start-page: 1533
  year: 2016
  ident: 10.1016/j.tcam.2022.100732_bib0004
  article-title: Resilience versus robustness in aging
  publication-title: J Gerontol. Ser. A
  doi: 10.1093/gerona/glw083
  contributor:
    fullname: Ukraintseva
– volume: 95
  start-page: 1954
  year: 2014
  ident: 10.1016/j.tcam.2022.100732_bib0067
  article-title: Using timed up and go and usual gait speed to predict incident disability in daily activities among community-dwelling adults aged 65 and older
  publication-title: Arch. Phys. Med. Rehabil.
  doi: 10.1016/j.apmr.2014.06.008
  contributor:
    fullname: Donoghue
– volume: 6
  start-page: 33276
  year: 2016
  ident: 10.1016/j.tcam.2022.100732_bib0052
  article-title: Multiple morbidities in companion dogs: a novel model for investigating age-related disease
  publication-title: Pathobiol. Aging Age Relat. Dis.
  doi: 10.3402/pba.v6.33276
  contributor:
    fullname: Jin
– volume: 60
  start-page: 1630
  year: 2017
  ident: 10.1016/j.tcam.2022.100732_bib0100
  article-title: Metformin and ageing: improving ageing outcomes beyond glycaemic control
  publication-title: Diabetologia
  doi: 10.1007/s00125-017-4349-5
  contributor:
    fullname: Valencia
– volume: 28
  start-page: 245
  year: 2005
  ident: 10.1016/j.tcam.2022.100732_bib0083
  article-title: Prospective study of physical activity and physical function in early old age
  publication-title: Am. J. Prev. Med.
  doi: 10.1016/j.amepre.2004.12.008
  contributor:
    fullname: Hillsdon
– volume: 56
  year: 2001
  ident: 10.1016/j.tcam.2022.100732_bib0011
  article-title: Frailty in older adults: evidence for a phenotype
  publication-title: J. Gerontol. A. Biol. Sci. Med. Sci.
  doi: 10.1093/gerona/56.3.M146
  contributor:
    fullname: Fried
– volume: 43
  start-page: 108
  year: 2020
  ident: 10.1016/j.tcam.2022.100732_bib0020
  article-title: The importance of physical function as a clinical outcome: assessment and enhancement
  publication-title: Clin. Cardiol.
  doi: 10.1002/clc.23311
  contributor:
    fullname: O'Neill
– volume: 48
  start-page: S57
  issue: SUPPL
  year: 2003
  ident: 10.1016/j.tcam.2022.100732_bib0030
  article-title: Fatigue and aging
  publication-title: Crit. Rev. Oncol. Hematol.
  doi: 10.1016/j.critrevonc.2003.07.003
  contributor:
    fullname: Tralongo
– volume: 71
  start-page: 14
  year: 2015
  ident: 10.1016/j.tcam.2022.100732_bib0001
  article-title: Why is the dog an ideal model for aging research?
  publication-title: Exp. Gerontol.
  doi: 10.1016/j.exger.2015.08.008
  contributor:
    fullname: Gilmore
– volume: 7
  start-page: 97
  year: 2020
  ident: 10.1016/j.tcam.2022.100732_bib0104
  article-title: Exercise but not supplemental dietary tryptophan influences heart rate and respiratory rate in sled dogs
  publication-title: Vet. Sci.
  doi: 10.3390/vetsci7030097
  contributor:
    fullname: Thornton
– volume: 41
  start-page: 712
  year: 2012
  ident: 10.1016/j.tcam.2022.100732_bib0068
  article-title: Performance-based physical function in older community-dwelling persons: a systematic review of instruments
  publication-title: Age Ageing
  doi: 10.1093/ageing/afs099
  contributor:
    fullname: Freiberger
– volume: 20
  year: 2020
  ident: 10.1016/j.tcam.2022.100732_bib0074
  article-title: Association of timed up and go test outcomes with future incidence of cardiovascular disease and mortality in adults aged 66 years: Korean national representative longitudinal study over 5.7 years
  publication-title: BMC Geriatr
  doi: 10.1186/s12877-020-01509-8
  contributor:
    fullname: Son
– volume: 24
  start-page: 371
  year: 2020
  ident: 10.1016/j.tcam.2022.100732_bib0066
  article-title: Handgrip strength and Timed Up-and-Go (TUG) test are predictors of short-term mortality among elderly in a population-based cohort in Singapore
  publication-title: J. Nutr. Health Aging
  doi: 10.1007/s12603-020-1337-0
  contributor:
    fullname: Chua
– volume: 28
  start-page: 379
  year: 2014
  ident: 10.1016/j.tcam.2022.100732_bib0076
  article-title: Long-term outcome and use of 6-minute walk test in West Highland White Terriers with idiopathic pulmonary fibrosis
  publication-title: J. Vet. Intern. Med.
  doi: 10.1111/jvim.12281
  contributor:
    fullname: Lilja-Maula
– volume: 23
  start-page: 153
  year: 2020
  ident: 10.1016/j.tcam.2022.100732_bib0044
  article-title: Association between social network and physical function in community-dwelling older adults in Japan
  publication-title: Phys. Ther. Res.
  doi: 10.1298/ptr.E10028
  contributor:
    fullname: Imamura
– volume: 26
  start-page: 583
  year: 2014
  ident: 10.1016/j.tcam.2022.100732_bib0072
  article-title: Association between six minute walk test and all-cause mortality, coronary heart disease-specific mortality, and incident coronary heart disease
  publication-title: J. Aging Health
  doi: 10.1177/0898264314525665
  contributor:
    fullname: Yazdanyar
– volume: 94
  start-page: 310
  year: 2010
  ident: 10.1016/j.tcam.2022.100732_bib0057
  article-title: Dog obesity: veterinary practices’ and owners’ opinions on cause and management
  publication-title: Prev. Vet. Med.
  doi: 10.1016/j.prevetmed.2010.01.013
  contributor:
    fullname: Bland
– volume: 9
  start-page: 1
  year: 2011
  ident: 10.1016/j.tcam.2022.100732_bib0096
  article-title: Treating frailty-a practical guide
  publication-title: BMC Med
  doi: 10.1186/1741-7015-9-83
  contributor:
    fullname: Fairhall
– volume: 16
  start-page: 21
  year: 2015
  ident: 10.1016/j.tcam.2022.100732_bib0018
  article-title: Associations between health-related quality of life and mortality in older adults
  publication-title: Prev. Sci.
  doi: 10.1007/s11121-013-0437-z
  contributor:
    fullname: Brown
– volume: 32
  start-page: 37
  year: 2017
  ident: 10.1016/j.tcam.2022.100732_bib0085
  article-title: A look at chronic pain in dogs
  publication-title: new pub Salt Media/Latcham
  contributor:
    fullname: Goldberg
– volume: 64
  start-page: 1679
  year: 2016
  ident: 10.1016/j.tcam.2022.100732_bib0015
  article-title: Association with mortality and heritability of the Scale of Aging Vigor in Epidemiology (SAVE)
  publication-title: J. Am. Geriatr. Soc.
  doi: 10.1111/jgs.14190
  contributor:
    fullname: Sanders
– year: 2013
  ident: 10.1016/j.tcam.2022.100732_bib0081
  contributor:
    fullname: Foster
– start-page: 227
  year: 2013
  ident: 10.1016/j.tcam.2022.100732_bib0084
  article-title: Recognition and Assessment of chronic pain in dogs
  publication-title: Pain Manag. Vet. Pract.
  doi: 10.1002/9781118999196.ch22
  contributor:
    fullname: Hielm-Björkman
– volume: 15
  start-page: 505
  year: 2018
  ident: 10.1016/j.tcam.2022.100732_bib0038
  article-title: Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
  publication-title: Nat. Rev. Cardiol.
  doi: 10.1038/s41569-018-0064-2
  contributor:
    fullname: Ferrucci
– volume: 11
  start-page: 2528
  year: 2021
  ident: 10.1016/j.tcam.2022.100732_bib0103
  article-title: Effects of interval exercise training on serum biochemistry and bone mineral density in dogs
  publication-title: Anim.
  doi: 10.3390/ani11092528
  contributor:
    fullname: Lee
– volume: 71
  start-page: 322
  year: 2010
  ident: 10.1016/j.tcam.2022.100732_bib0048
  article-title: Evaluation of the effect of signalment and body conformation on activity monitoring in companion dogs
  publication-title: Am. J. Vet. Res.
  doi: 10.2460/ajvr.71.3.322
  contributor:
    fullname: Brown
– volume: 2015
  year: 2015
  ident: 10.1016/j.tcam.2022.100732_bib0091
  article-title: Initial evaluation of nighttime restlessness in a naturally occurring canine model of osteoarthritis pain
  publication-title: PeerJ
  contributor:
    fullname: Knazovicky
– ident: 10.1016/j.tcam.2022.100732_bib0031
  doi: 10.1177/20587392211026109
– volume: 43
  start-page: 241
  year: 2014
  ident: 10.1016/j.tcam.2022.100732_bib0087
  article-title: The Canine Orthopedic Index. Step 2: psychometric testing
  publication-title: Vet. Surg.
  doi: 10.1111/j.1532-950X.2014.12141.x
  contributor:
    fullname: Brown
– volume: 14
  start-page: 499
  year: 2002
  ident: 10.1016/j.tcam.2022.100732_bib0017
  article-title: Relationship of health-related quality of life to health care utilization and mortality among older adults
  publication-title: Aging Clin. Exp. Res.
  doi: 10.1007/BF03327351
  contributor:
    fullname: Dominick
– year: 2022
  ident: 10.1016/j.tcam.2022.100732_bib0050
  article-title: Age and physical activity levels in companion dogs: results from the dog aging project
  publication-title: J Gerontol. Ser. A
  doi: 10.1093/gerona/glac099
  contributor:
    fullname: Lee
– ident: 10.1016/j.tcam.2022.100732_bib0024
  doi: 10.1101/2022.04.20.488879
– volume: 108
  start-page: 143
  year: 2007
  ident: 10.1016/j.tcam.2022.100732_bib0064
  article-title: Quality of life of the pet dog: influence of owner and dog's characteristics
  publication-title: Appl. Anim. Behav. Sci.
  doi: 10.1016/j.applanim.2006.11.018
  contributor:
    fullname: Marinelli
– volume: 83
  start-page: 83
  year: 2015
  ident: 10.1016/j.tcam.2022.100732_bib0097
  article-title: Physical exercise as therapy for frailty
  publication-title: Nestle Nutr. Inst. Workshop Ser.
  doi: 10.1159/000382065
  contributor:
    fullname: Aguirre
– volume: 71
  start-page: 1184
  year: 2016
  ident: 10.1016/j.tcam.2022.100732_bib0021
  article-title: Age-related change in mobility: perspectives from life course epidemiology and geroscience
  publication-title: J. Gerontol. A. Biol. Sci. Med. Sci.
  doi: 10.1093/gerona/glw043
  contributor:
    fullname: Ferrucci
– volume: 66
  start-page: 89
  year: 2011
  ident: 10.1016/j.tcam.2022.100732_bib0071
  article-title: Predictive value of the short physical performance battery following hospitalization in older patients
  publication-title: J. Gerontol. A. Biol. Sci. Med. Sci.
  doi: 10.1093/gerona/glq167
  contributor:
    fullname: Volpato
– volume: 2012
  year: 2012
  ident: 10.1016/j.tcam.2022.100732_bib0095
  article-title: Interventions for preventing falls in older people living in the community
  publication-title: Cochrane Database Syst. Rev.
  contributor:
    fullname: Gillespie
– volume: 177
  start-page: 867
  year: 2007
  ident: 10.1016/j.tcam.2022.100732_bib0101
  article-title: Effect of perindopril on physical function in elderly people with functional impairment: a randomized controlled trial
  publication-title: CMAJ
  doi: 10.1503/cmaj.061339
  contributor:
    fullname: Sumukadas
– volume: 57
  start-page: 55
  year: 2004
  ident: 10.1016/j.tcam.2022.100732_bib0023
  article-title: Comorbidity of somatic chronic diseases and decline in physical functioning: the Longitudinal Aging Study Amsterdam
  publication-title: J. Clin. Epidemiol.
  doi: 10.1016/S0895-4356(03)00258-0
  contributor:
    fullname: Kriegsman
– volume: 75
  start-page: 65
  year: 2002
  ident: 10.1016/j.tcam.2022.100732_bib0049
  article-title: Age-dependent decline in locomotor activity in dogs is environment specific
  publication-title: Physiol. Behav.
  doi: 10.1016/S0031-9384(01)00632-1
  contributor:
    fullname: Siwak
– volume: 16
  start-page: 1
  year: 2020
  ident: 10.1016/j.tcam.2022.100732_bib0026
  article-title: Slower, shorter, sadder: a qualitative study exploring how dog walks change when the canine participant develops osteoarthritis
  publication-title: BMC Vet. Res.
  doi: 10.1186/s12917-020-02293-8
  contributor:
    fullname: Belshaw
– volume: 22
  start-page: 100
  year: 2013
  ident: 10.1016/j.tcam.2022.100732_bib0028
  article-title: Fatigue in older adults: an early indicator of the aging process?
  publication-title: Aging Clin. Exp. Res.
  doi: 10.1007/BF03324782
  contributor:
    fullname: Avlund
– volume: 71
  start-page: 1243
  year: 2016
  ident: 10.1016/j.tcam.2022.100732_bib0033
  article-title: Editor's choice: comparative approaches to understanding the relation between aging and physical function
  publication-title: J Gerontol. Ser. A Biol. Sci. Med. Sci.
  doi: 10.1093/gerona/glv035
  contributor:
    fullname: Justice
– volume: 8
  start-page: 55
  year: 2019
  ident: 10.1016/j.tcam.2022.100732_bib0090
  article-title: Wearable sensor technology to measure Physical Activity (PA) in the elderly
  publication-title: Curr. Geriatr. Reports
  doi: 10.1007/s13670-019-0275-3
  contributor:
    fullname: Rao
– volume: 8
  start-page: e58125
  year: 2013
  ident: 10.1016/j.tcam.2022.100732_bib0088
  article-title: Evaluation of construct and criterion validity for the ‘Liverpool Osteoarthritis in Dogs’ (LOAD) Clinical Metrology Instrument and Comparison to Two Other Instruments
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0058125
  contributor:
    fullname: Walton
– volume: 70
  start-page: 78
  year: 2015
  ident: 10.1016/j.tcam.2022.100732_bib0027
  article-title: Fatigue: relevance and implications in the aging population
  publication-title: Exp. Gerontol.
  doi: 10.1016/j.exger.2015.07.011
  contributor:
    fullname: Zengarini
– volume: 40
  start-page: 42
  year: 2018
  ident: 10.1016/j.tcam.2022.100732_bib0080
  article-title: How do I know my animal got better?’ – measuring outcomes in small animal orthopaedics
  publication-title: In Pract
  doi: 10.1136/inp.k647
  contributor:
    fullname: Walton
– volume: 173
  start-page: 489
  year: 2005
  ident: 10.1016/j.tcam.2022.100732_bib0107
  article-title: A global clinical measure of fitness and frailty in elderly people
  publication-title: CMAJ
  doi: 10.1503/cmaj.050051
  contributor:
    fullname: Rockwood
SSID ssj0060988
Score 2.3809578
SecondaryResourceType review_article
Snippet Aging is the leading cause of disability, disease, and death in adult dogs. One major consequence of aging is diminishing physical function. For normal...
SourceID proquest
crossref
elsevier
SourceType Aggregation Database
Publisher
StartPage 100732
SubjectTerms Age
Aging
Assessments
Biological activity
canine aging
Cardiovascular disease
Death
Dogs
Evaluation
Exercise
Frailty
Geriatrics
Health risks
healthspan
Medical treatment
Morbidity
Muscle strength
Older people
Phenotypes
physical dysfunction
Physical exercise
Physical fitness
Quality of life
Recovery of function
Sarcopenia
Veterinary medicine
Title Assessment and Management of Declining Physical Function in Aging Dogs
URI https://dx.doi.org/10.1016/j.tcam.2022.100732
https://www.proquest.com/docview/2740899494
https://search.proquest.com/docview/2728144785
Volume 51
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1NTwIxEG0IXrwYRY0okpp4MyvQdpfukYAENRATxXBr-rEleFiIwNXf7rTbxWiiB4_dne02b9o303Smg9C1ZcSC4eNREhMZsYTaSHYtj4yVssOMTbm_p3s8SUZT9jCLZxXUL3NhXFhl4P6C0z1bhyetgGZrtVi0nsH14GkXCJj4Mo-OhxmYP5jTtx-7MI-knfrak044ctIhcaaI8dpo6bLRCfHBApT8Zpx-0LS3PcNDdBCcRtwrxnWEKlleQ7VXF8ni02nxOJyQH6Nhb3fVJpa5wV_hLXhp8SDzmZD5HD8F_eAhGDanHLzIcc9VLMKD5Xx9gqbDu5f-KAq1EiJNabyJqIxlqmH3oZVJYmooJ4prqyQwkiLapZSCL6fallMDk0dmbdeiSidMcmMkPUXVfJlnZwjLGNSXEmKgB9aRKiXQKVVGapDjmtTRTQmSWBVXYogyVuxNOEiFg1QUkNZRXOIovilWAGf_-V2jBF2EZbUWsIV2x5QsZXV0tXsNC8Kdcsg8W26dDOGwS-zy-Pyfv75A-65VZBw2UHXzvs0uwfXYqKafW02017t_HE0-AcuR2Go
link.rule.ids 315,783,787,4509,24128,27936,27937,45597,45691
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LTwIxEG4IHvRiFDXisybezAq03aV7JCJBBWIiGG5NH1uCh4UoXv3tTrtdjCZ68Ljb2W7zTfvNNJ3pIHRpGbFg-HiUxERGLKE2km3LI2OlbDFjU-7v6R6Okv6E3U_jaQXdlLkwLqwycH_B6Z6tw5tGQLOxnM8bT-B68LQNBEx8mUfg4Q3m_GOY1Ncf6ziPpJn64pNOOnLiIXOmCPJaaenS0Qnx0QKU_GadfvC0Nz69HbQdvEbcKQa2iypZXkO1ZxfK4vNp8TAcke-hXmd91yaWucFf8S14YXE386mQ-Qw_BgXhHlg2px08z3HHlSzC3cXsbR9Nerfjm34UiiVEmtJ4FVEZy1TD9kMrk8TUUE4U11ZJoCRFtMspBWdONS2nBmaPzJruiSqdMMmNkfQAVfNFnh0iLGPQX0qIgR5YS6qUQKdUGalBjmtSR1clSGJZ3IkhymCxF-EgFQ5SUUBaR3GJo_imWQGk_ed3JyXoIqyrNwF7aHdOyVJWRxfrZlgR7phD5tni3ckQDtvENo-P_vnrc7TZHw8HYnA3ejhGW66lSD88QdXV63t2Cn7ISp35efYJ-7faAw
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Assessment+and+Management+of+Declining+Physical+Function+in+Aging+Dogs&rft.jtitle=Topics+in+companion+animal+medicine&rft.au=McKenzie%2C+Brennen+A.&rft.au=Chen%2C+Frances+L.&rft.date=2022-11-01&rft.pub=Elsevier+Inc&rft.issn=1938-9736&rft.eissn=1946-9837&rft.volume=51&rft_id=info:doi/10.1016%2Fj.tcam.2022.100732&rft.externalDocID=S1938973622001052
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1938-9736&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1938-9736&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1938-9736&client=summon