Towards Dual-Tracer SPECT for Prostate Cancer Imaging Using [99mTc]Tc-PSMA-I&S and [111In]In-RM2

• Published in: Pharmaceuticals (Basel, Switzerland) Vol. 18; no. 7; p. 1002
• Main Authors: Giammei, Carolina, Balber, Theresa, Felber, Veronika, Dillinger, Thomas, Cardinale, Jens, Brandt, Marie R., Stingeder, Anna, Mitterhauser, Markus, Egger, Gerda, Mindt, Thomas L.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 03.07.2025; MDPI
• Subjects: Antigens; Biodistribution; Biomarkers; Cancer therapies; Cloning; Isotopes; Ligands; Localization; Metastasis; Nuclear medicine; Patients; Peptides; Prostate cancer; indium-111; PSMA; CHO-K1-GRPR; technetium-99m; GRPR; CHO-K1-PSMA; SPECT; dual-tracer approach; tumor heterogeneity

Background/Objectives: Radiolabeled biomolecules specifically targeting overexpressed structures on tumor cells hold great potential for prostate cancer (PCa) imaging and therapy. Due to heterogeneous target expression, single radiopharmaceuticals may not detect or treat all lesions, while simultane...