Genetic Determinants of White Matter Hyperintensities on Brain Scans A Systematic Assessment of 19 Candidate Gene Polymorphisms in 46 Studies in 19 000 Subjects

• Published in: Stroke (1970) Vol. 40; no. 6; pp. 2020 - 2026
• Main Authors: Paternoster, Lavinia, Chen, Wanting, Sudlow, Cathie L.M.
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.06.2009
• Subjects: Apolipoproteins E - genetics; Biological and medical sciences; Brain - pathology; Brain Ischemia - epidemiology; Brain Ischemia - genetics; Brain Ischemia - pathology; Gene Frequency; Genotype; Humans; Medical sciences; Methylenetetrahydrofolate Reductase (NADPH2) - genetics; Neurology; Neuropharmacology; Neuroprotective agent; O-Methylguanine-DNA Methyltransferase - genetics; Odds Ratio; Peptidyl-Dipeptidase A - genetics; Pharmacology. Drug treatments; Polymorphism, Genetic - physiology; Stroke - epidemiology; Stroke - genetics; Stroke - pathology; Vascular diseases and vascular malformations of the nervous system; Human; Stroke; Nervous system diseases; white matter hyperintensities; meta-analysis; Cardiovascular disease; White matter; Cerebral disorder; Encephalon; Vascular disease; genetics; Central nervous system disease; Hyperintensity; Cerebrovascular disease; Polymorphism

Background and Purpose— White matter hyperintensities (WMH) are highly heritable and associated with small artery ischemic stroke, so they may be a useful trait for studying the genetics of small vessel disease. Many studies have attempted to find associations between polymorphisms in various candid...