Lesion level-dependent systemic muscle wasting after spinal cord injury is mediated by glucocorticoid signaling in mice

• Published in: Science translational medicine Vol. 15; no. 727; p. eadh2156
• Main Authors: Harrigan, Markus E, Filous, Angela R, Vadala, Christopher P, Webb, Amy, Pietrzak, Maciej, Sahenk, Zarife, Prüss, Harald, Reiser, Peter J, Popovich, Phillip G, Arnold, W David, Schwab, Jan M
• Format: Journal Article
• Language: English
• Published: United States 20.12.2023
• Subjects: Animals; Glucocorticoids; Mice; Muscle, Skeletal - metabolism; Spinal Cord - metabolism; Spinal Cord Injuries - pathology

An incomplete mechanistic understanding of skeletal muscle wasting early after spinal cord injury (SCI) precludes targeted molecular interventions. Here, we demonstrated systemic wasting that also affected innervated nonparalyzed (supralesional) muscles and emerged within 1 week after experimental S...