Effects of hyperoxia on the dynamic expression of Aquaporin5 in premature rats lung development

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences Vol. 27; no. 3; pp. 318 - 320
• Main Authors: Lu, Hongyan, Chang, Liwen, Li, Wenbin, Jiang, Na, Peng, Qiongling, Cai, Cheng, Liu, Jing
• Format: Journal Article
• Language: English
• Published: China Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430030 China 01.06.2007
• Subjects: Animals; Animals, Newborn; Aquaporin 5 - genetics; Aquaporin 5 - metabolism; Blotting, Western; Down-Regulation; Female; Gene Expression; Hypoxia - complications; Immunohistochemistry; Lung - growth & development; Lung - metabolism; Male; Pregnancy; Random Allocation; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome, Adult - etiology; Respiratory Distress Syndrome, Adult - genetics; Respiratory Distress Syndrome, Adult - metabolism; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - biosynthesis; RNA, Messenger - genetics; premature; water balance; hyperoxia; aquaporin 5; lung development

To explore the dynamic expression and role of Aquaporin5 (AQP5) in lung development and hyperoxia lung injury, gestation 21-day Sprague-Dawley (SD) rats (term=22 days) were randomly assigned to air group and hyperoxia group within 12-24 h after birth. The rats in hyperoxia group were continuously ex...