Selective Cyclooxygenase-2 Inhibition by Nimesulide in Man

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 287; no. 2; pp. 578 - 582
• Main Authors: Cullen, Louise, Kelly, Linda, Connor, Shane O., Fitzgerald, Desmond J.
• Format: Journal Article
• Language: English
• Published: United States American Society for Pharmacology and Experimental Therapeutics 01.11.1998
• Subjects: Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors - pharmacology; Female; Humans; Isoenzymes - drug effects; Male; Membrane Proteins; Middle Aged; Platelet Aggregation - drug effects; Prostaglandin-Endoperoxide Synthases - drug effects; Prostaglandins - biosynthesis; Prostaglandins - urine; Sulfonamides - pharmacology; Thromboxane B2 - analogs & derivatives; Thromboxane B2 - urine
• ISSN: 0022-3565; 1521-0103
• DOI: 10.1016/s0022-3565(24)37830-9

Prostaglandins are generated through two isoforms of the enzyme cyclooxygenase, the constitutively expressed cyclooxygenase (Cox)-1 and Cox-2, which is induced at sites of inflammation. Selective inhibition of Cox-2 is desirable as this may avoid the gastropathy and platelet inhibition seen with non...