Cu(II)-triggered release of paclitaxel from a supramolecular complex

The research on the stimuli-responsive property of biological or synthetic macromolecules in a wide range of scientific fields is a crucial subject for the achievements of the targeted drug release and the precise control of the functions of the supramolecules at a molecular level. We used an anthra...

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Published inSupramolecular chemistry Vol. 25; no. 5; pp. 302 - 309
Main Authors Sun, Tao, Yan, Hui, Xing, Pengyao, Su, Jie, Li, Shangyang, Hao, Aiyou
Format Journal Article
LanguageEnglish
Published Abingdon Taylor & Francis Group 01.05.2013
Taylor & Francis Ltd
Subjects
controlled release
cyclodextrin
Electron microscopes
paclitaxel Cu
stimuli-responsive
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Abstract The research on the stimuli-responsive property of biological or synthetic macromolecules in a wide range of scientific fields is a crucial subject for the achievements of the targeted drug release and the precise control of the functions of the supramolecules at a molecular level. We used an anthraquinone-functioned cyclodextrin (1) bridged by an aza-arm to solubilise paclitaxel (PTX) by forming a supramolecular complex (1/PTX). The possible inclusion mode was given based on the experimental results of ultraviolet-visible spectroscopy, Fourier transform infrared, X-ray diffraction, fluorescence spectra, nuclear magnetic resonance, transmission electron microscope, scanning electron microscope and dynamic light scattering characterisations. The controlled release of PTX can be achieved by adding Cu 2+ to the solution. This study provides useful references in developing stimuli-responsive drug-carrying and drug-releasing materials.
AbstractList The research on the stimuli-responsive property of biological or synthetic macromolecules in a wide range of scientific fields is a crucial subject for the achievements of the targeted drug release and the precise control of the functions of the supramolecules at a molecular level. We used an anthraquinone-functioned cyclodextrin (1) bridged by an aza-arm to solubilise paclitaxel (PTX) by forming a supramolecular complex (1/PTX). The possible inclusion mode was given based on the experimental results of ultraviolet-visible spectroscopy, Fourier transform infrared, X-ray diffraction, fluorescence spectra, nuclear magnetic resonance, transmission electron microscope, scanning electron microscope and dynamic light scattering characterisations. The controlled release of PTX can be achieved by adding Cu 2+ to the solution. This study provides useful references in developing stimuli-responsive drug-carrying and drug-releasing materials.
The research on the stimuli-responsive property of biological or synthetic macromolecules in a wide range of scientific fields is a crucial subject for the achievements of the targeted drug release and the precise control of the functions of the supramolecules at a molecular level. We used an anthraquinone-functioned cyclodextrin (1) bridged by an aza-arm to solubilise paclitaxel (PTX) by forming a supramolecular complex (1/PTX). The possible inclusion mode was given based on the experimental results of ultraviolet-visible spectroscopy, Fourier transform infrared, X-ray diffraction, fluorescence spectra, nuclear magnetic resonance, transmission electron microscope, scanning electron microscope and dynamic light scattering characterisations. The controlled release of PTX can be achieved by adding Cu2+ to the solution. This study provides useful references in developing stimuli-responsive drug-carrying and drug-releasing materials. [PUBLICATION ABSTRACT]
Author Xing, Pengyao
Sun, Tao
Li, Shangyang
Hao, Aiyou
Yan, Hui
Su, Jie
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SubjectTerms controlled release
cyclodextrin
Electron microscopes
paclitaxel Cu
stimuli-responsive
Title Cu(II)-triggered release of paclitaxel from a supramolecular complex
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