Central nervous system histoplasmosis: Multicenter retrospective study on clinical features, diagnostic approach and outcome of treatment

• Published in: Medicine (Baltimore) Vol. 97; no. 13; p. e0245
• Main Authors: Wheat, Joseph, Myint, Thein, Guo, Ying, Kemmer, Phebe, Hage, Chadi, Terry, Colin, Azar, Marwan M., Riddell, James, Ender, Peter, Chen, Sharon, Shehab, Kareem, Cleveland, Kerry, Esguerra, Eden, Johnson, James, Wright, Patty, Douglas, Vanja, Vergidis, Pascalis, Ooi, Winnie, Baddley, John, Bamberger, David, Khairy, Raed, Vikram, Holenarasipur R., Jenny-Avital, Elizabeth, Sivasubramanian, Geetha, Bowlware, Karen, Pahud, Barbara, Sarria, Juan, Tsai, Townson, Assi, Maha, Mocherla, Satish, Prakash, Vidhya, Allen, David, Passaretti, Catherine, Huprikar, Shirish, Anderson, Albert
• Format: Journal Article
• Language: English
• Published: United States The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved 01.03.2018; Wolters Kluwer Health
• Subjects: Acquired Immunodeficiency Syndrome - complications; Age Factors; Amphotericin B - therapeutic use; Antibodies, Fungal - cerebrospinal fluid; Antigens, Fungal - cerebrospinal fluid; Brain - diagnostic imaging; Central Nervous System Fungal Infections - complications; Central Nervous System Fungal Infections - diagnosis; Central Nervous System Fungal Infections - drug therapy; Central Nervous System Fungal Infections - mortality; Female; Histoplasmosis - complications; Histoplasmosis - diagnosis; Histoplasmosis - drug therapy; Histoplasmosis - mortality; Humans; Immunocompromised Host; Magnetic Resonance Imaging; Male; Middle Aged; Observational Study; Retrospective Studies; Spinal Cord - drug effects

Central nervous system (CNS) involvement occurs in 5 to 10% of individuals with disseminated histoplasmosis. Most experience has been derived from small single center case series, or case report literature reviews. Therefore, a larger study of central nervous system (CNS) histoplasmosis is needed in...