Expected 8-Week Prenatal vs 12-Week Perinatal Tenofovir Alafenamide Prophylaxis to Prevent Mother-to-Child Transmission of Hepatitis B Virus: A Multicenter, Prospective, Open-Label, Randomized Controlled Trial

• Published in: The American journal of gastroenterology Vol. 120; no. 5; pp. 1045 - 1056
• Main Authors: Zeng, Qing-Lei, Zhou, Yi-Hua, Dong, Xiao-Ping, Zhang, Ji-Yuan, Li, Guang-Ming, Xu, Jiang-Hai, Chen, Zhi-Min, Song, Ning, Zhang, Hong-Xu, Chen, Ru-Yue, Lv, Xue-Yan, Huang, Shuo, Li, Wei-Zhe, Pan, Ya-Jie, Feng, Ying-Hua, Li, Zhi-Qin, Zhang, Guo-Fan, Lin, Wan-Bao, Zhang, Guo-Qiang, Li, Guo-Tao, Li, Wei, Zeng, Yan-Li, Zhang, Da-Wei, Cui, Guang-Lin, Lv, Jun, Liu, Yan-Min, Liang, Hong-Xia, Sun, Chang-Yu, Wang, Fu-Sheng, Yu, Zu-Jiang
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Wolters Kluwer 01.05.2025; Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins
• Subjects: Adenine - administration & dosage; Adenine - analogs & derivatives; Adenine - therapeutic use; Adult; Alanine; Antibodies; Antigens; Antiviral Agents - administration & dosage; Antiviral Agents - therapeutic use; Clinical trials; Disease prevention; DNA, Viral; Drug dosages; Female; Hepatitis B; Hepatitis B - prevention & control; Hepatitis B - transmission; Hepatitis B virus - genetics; Humans; Infant; Infant, Newborn; Infections; Infectious Disease Transmission, Vertical - prevention & control; Jaundice; Mothers; Postpartum period; Pregnancy; Pregnancy Complications, Infectious - drug therapy; Prospective Studies; Tenofovir - administration & dosage; Tenofovir - analogs & derivatives; Tenofovir - therapeutic use; Vaccines; Womens health; Young Adult; Ireland; tenofovir alafenamide; hepatitis B virus; safety; efficacy; pregnancy; mother-to-child transmission

INTRODUCTION:The course of maternal antiviral prophylaxis to prevent mother-to-child transmission of hepatitis B virus (HBV-MTCT) varies greatly, and it has not been demonstrated in a randomized controlled study.METHODS:In this multicenter, open-label, randomized controlled trial, eligible pregnant...